Gene description for SLC22A18
Gene name solute carrier family 22, member 18
Gene symbol SLC22A18
Other names/aliases BWR1A
BWSCR1A
HET
IMPT1
ITM
ORCTL2
SLC22A1L
TSSC5
p45-BWR1A
Species Homo sapiens
 Database cross references - SLC22A18
ExoCarta ExoCarta_5002
Vesiclepedia VP_5002
Entrez Gene 5002
HGNC 10964
MIM 602631
UniProt Q96BI1  
 SLC22A18 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC22A18
Molecular Function
    protein binding GO:0005515 IPI
    symporter activity GO:0015293 IEA
    ubiquitin protein ligase binding GO:0031625 IPI
    xenobiotic transmembrane transporter activity GO:0042910 TAS
Biological Process
    monoatomic ion transport GO:0006811 IEA
    organic cation transport GO:0015695 NAS
    xenobiotic transport GO:0042908 IDA
    xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 IBA
    xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 IDA
Subcellular Localization
    nuclear envelope GO:0005635 IBA
    nuclear envelope GO:0005635 IDA
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 HDA
    membrane GO:0016020 NAS
    apical plasma membrane GO:0016324 IDA
 Experiment description of studies that identified SLC22A18 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC22A18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NRG1 3084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SLC39A12  
Affinity Capture-MS Homo sapiens
3 GYPA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SLC30A9 10463
Affinity Capture-MS Homo sapiens
5 HSD17B11 51170
Two-hybrid Homo sapiens
6 CA14 23632
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 KLK8 11202
Affinity Capture-MS Homo sapiens
8 RNF167 26001
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
9 LAMP3  
Affinity Capture-MS Homo sapiens
10 SLC39A4 55630
Affinity Capture-MS Homo sapiens
11 TXNDC15  
Affinity Capture-MS Homo sapiens
12 OXA1L  
Affinity Capture-MS Homo sapiens
13 TNFSF8  
Affinity Capture-MS Homo sapiens
14 MME 4311
Affinity Capture-MS Homo sapiens
15 VSIG1  
Affinity Capture-MS Homo sapiens
16 CLEC2D  
Affinity Capture-MS Homo sapiens
17 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SLC39A8 64116
Affinity Capture-MS Homo sapiens
19 CRELD1 78987
Affinity Capture-MS Homo sapiens
20 TMEM186  
Affinity Capture-MS Homo sapiens
21 MRAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 NKX3-1  
Two-hybrid Homo sapiens
23 ITM2A  
Affinity Capture-MS Homo sapiens
24 SPACA1 81833
Affinity Capture-MS Homo sapiens
25 TM9SF3 56889
Affinity Capture-MS Homo sapiens
26 CHST10  
Affinity Capture-MS Homo sapiens
27 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 SLC20A1 6574
Affinity Capture-MS Homo sapiens
29 HLA-DPA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 TMCO1 54499
Affinity Capture-MS Homo sapiens
31 KITLG  
Affinity Capture-MS Homo sapiens
32 POMK  
Affinity Capture-MS Homo sapiens
33 SLC39A5 283375
Affinity Capture-MS Homo sapiens
34 C3AR1  
Affinity Capture-MS Homo sapiens
35 ABHD17B 51104
Affinity Capture-MS Homo sapiens
36 AMIGO3  
Affinity Capture-MS Homo sapiens
37 PMEL 6490
Affinity Capture-MS Homo sapiens
38 EPHA1 2041
Affinity Capture-MS Homo sapiens
39 TMEM56  
Two-hybrid Homo sapiens
40 TMX2 51075
Two-hybrid Homo sapiens
41 SLC7A1 6541
Affinity Capture-MS Homo sapiens
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