Gene description for HSD17B11
Gene name hydroxysteroid (17-beta) dehydrogenase 11
Gene symbol HSD17B11
Other names/aliases 17-BETA-HSD11
17-BETA-HSDXI
17BHSD11
DHRS8
PAN1B
RETSDR2
SDR16C2
Species Homo sapiens
 Database cross references - HSD17B11
ExoCarta ExoCarta_51170
Vesiclepedia VP_51170
Entrez Gene 51170
HGNC 22960
MIM 612831
UniProt Q8NBQ5  
 HSD17B11 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for HSD17B11
Molecular Function
    estradiol 17-beta-dehydrogenase [NAD(P)+] activity GO:0004303 IDA
    estradiol 17-beta-dehydrogenase [NAD(P)+] activity GO:0004303 TAS
    protein binding GO:0005515 IPI
    steroid dehydrogenase activity GO:0016229 IBA
    steroid dehydrogenase activity GO:0016229 IDA
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 IBA
Biological Process
    estrogen biosynthetic process GO:0006703 TAS
    androgen catabolic process GO:0006710 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IEA
    lipid droplet GO:0005811 IBA
    lipid droplet GO:0005811 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified HSD17B11 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for HSD17B11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
2 ITGB1 3688
Proximity Label-MS Homo sapiens
3 LOC100507537  
Two-hybrid Homo sapiens
4 ARHGAP1 392
Proximity Label-MS Homo sapiens
5 CSGALNACT2 55454
Two-hybrid Homo sapiens
6 CCNB2  
Proximity Label-MS Homo sapiens
7 SRPRB 58477
Proximity Label-MS Homo sapiens
8 HACD3 51495
Proximity Label-MS Homo sapiens
9 JPH1 56704
Proximity Label-MS Homo sapiens
10 VMP1 81671
Proximity Label-MS Homo sapiens
11 DHRSX 207063
Two-hybrid Homo sapiens
12 BTN3A3 10384
Proximity Label-MS Homo sapiens
13 TACC2 10579
Proximity Label-MS Homo sapiens
14 LPCAT1 79888
Proximity Label-MS Homo sapiens
15 C18orf32  
Proximity Label-MS Homo sapiens
16 IARS2 55699
Proximity Label-MS Homo sapiens
17 RINT1 60561
Proximity Label-MS Homo sapiens
18 SMPD4 55627
Proximity Label-MS Homo sapiens
19 DGKE  
Proximity Label-MS Homo sapiens
20 ARF1 375
Proximity Label-MS Homo sapiens
21 ABCD3 5825
Proximity Label-MS Homo sapiens
22 SFXN3 81855
Two-hybrid Homo sapiens
23 C10orf35  
Two-hybrid Homo sapiens
24 USP33  
Proximity Label-MS Homo sapiens
25 SLC25A46 91137
Two-hybrid Homo sapiens
26 BET1 10282
Proximity Label-MS Homo sapiens
27 SLC30A9 10463
Proximity Label-MS Homo sapiens
28 SLC6A15 55117
Proximity Label-MS Homo sapiens
29 FAM177A1 283635
Proximity Label-MS Homo sapiens
30 RASGRP3  
Two-hybrid Homo sapiens
31 NOTCH2 4853
Proximity Label-MS Homo sapiens
32 CAMLG 819
Proximity Label-MS Homo sapiens
33 ATP2A2 488
Proximity Label-MS Homo sapiens
34 SENP2 59343
Proximity Label-MS Homo sapiens
35 HTATIP2 10553
Two-hybrid Homo sapiens
36 TMX1 81542
Proximity Label-MS Homo sapiens
37 GGT7 2686
Proximity Label-MS Homo sapiens
38 CERS2 29956
Proximity Label-MS Homo sapiens
39 UBXN8  
Proximity Label-MS Homo sapiens
40 CLCC1 23155
Proximity Label-MS Homo sapiens
41 SAR1B 51128
Proximity Label-MS Homo sapiens
42 GORASP2 26003
Proximity Label-MS Homo sapiens
43 SYNE1 23345
Proximity Label-MS Homo sapiens
44 ACBD5 91452
Proximity Label-MS Homo sapiens
45 C16orf58 64755
Proximity Label-MS Homo sapiens
46 REEP5 7905
Proximity Label-MS Homo sapiens
47 TMPO 7112
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
48 ANO6 196527
Proximity Label-MS Homo sapiens
49 AGPAT1 10554
Proximity Label-MS Homo sapiens
50 LRRC59 55379
Proximity Label-MS Homo sapiens
51 LMNB1 4001
Proximity Label-MS Homo sapiens
52 SCAMP1 9522
Proximity Label-MS Homo sapiens
53 LYSMD3  
Proximity Label-MS Homo sapiens
54 BCAP31 10134
Proximity Label-MS Homo sapiens
55 UBC 7316
Reconstituted Complex Homo sapiens
56 ATP6AP2 10159
Proximity Label-MS Homo sapiens
57 FKBP8 23770
Proximity Label-MS Homo sapiens
58 AAAS 8086
Proximity Label-MS Homo sapiens
59 CYP51A1 1595
Proximity Label-MS Homo sapiens
60 TMEM173  
Proximity Label-MS Homo sapiens
61 ZW10 9183
Proximity Label-MS Homo sapiens
62 SOAT1 6646
Proximity Label-MS Homo sapiens
63 TMCO1 54499
Proximity Label-MS Homo sapiens
64 PLP2 5355
Two-hybrid Homo sapiens
65 SYS1  
Two-hybrid Homo sapiens
66 TMX2 51075
Two-hybrid Homo sapiens
67 GOLGB1 2804
Proximity Label-MS Homo sapiens
68 SLC4A2 6522
Proximity Label-MS Homo sapiens
69 MAGEA8  
Affinity Capture-MS Homo sapiens
70 TMEM57  
Proximity Label-MS Homo sapiens
71 AGPAT9  
Proximity Label-MS Homo sapiens
72 WWOX 51741
Proximity Label-MS Homo sapiens
73 CLPTM1 1209
Proximity Label-MS Homo sapiens
74 CMTM3 123920
Two-hybrid Homo sapiens
75 PTPN2 5771
Proximity Label-MS Homo sapiens
76 ITPR3 3710
Proximity Label-MS Homo sapiens
77 PTDSS1 9791
Proximity Label-MS Homo sapiens
78 RABL3 285282
Proximity Label-MS Homo sapiens
79 HM13 81502
Proximity Label-MS Homo sapiens
80 NDC1 55706
Proximity Label-MS Homo sapiens
81 RAB11A 8766
Proximity Label-MS Homo sapiens
82 ITPR1 3708
Proximity Label-MS Homo sapiens
83 TMEM199  
Proximity Label-MS Homo sapiens
84 EI24  
Proximity Label-MS Homo sapiens
85 CISD2 493856
Proximity Label-MS Homo sapiens
86 WFS1 7466
Proximity Label-MS Homo sapiens
87 PRAF2 11230
Two-hybrid Homo sapiens
88 VANGL1 81839
Proximity Label-MS Homo sapiens
89 BRI3BP 140707
Proximity Label-MS Homo sapiens
90 AIFM2 84883
Proximity Label-MS Homo sapiens
91 C2CD2L 9854
Proximity Label-MS Homo sapiens
92 KIF16B 55614
Proximity Label-MS Homo sapiens
93 AFG3L2 10939
Proximity Label-MS Homo sapiens
94 DDHD2 23259
Proximity Label-MS Homo sapiens
95 SPRTN  
Affinity Capture-MS Homo sapiens
96 ATL1 51062
Proximity Label-MS Homo sapiens
97 SACM1L 22908
Affinity Capture-MS Homo sapiens
98 DHRS7 51635
Proximity Label-MS Homo sapiens
99 GJA1 2697
Proximity Label-MS Homo sapiens
100 ARL6IP5 10550
Proximity Label-MS Homo sapiens
101 SRPR 6734
Proximity Label-MS Homo sapiens
102 GOSR2 9570
Proximity Label-MS Homo sapiens
103 COPA 1314
Affinity Capture-MS Homo sapiens
104 NUP160 23279
Proximity Label-MS Homo sapiens
105 ATP5L 10632
Affinity Capture-MS Homo sapiens
106 GIMAP1  
Two-hybrid Homo sapiens
107 VANGL2  
Proximity Label-MS Homo sapiens
108 EBP  
Proximity Label-MS Homo sapiens
109 WDR41  
Proximity Label-MS Homo sapiens
110 TMEM65 157378
Two-hybrid Homo sapiens
111 ELOVL2  
Proximity Label-MS Homo sapiens
112 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
113 DGAT2L6  
Two-hybrid Homo sapiens
114 NEU1 4758
Two-hybrid Homo sapiens
115 CANX 821
Proximity Label-MS Homo sapiens
116 LMAN1 3998
Proximity Label-MS Homo sapiens
117 KIAA1715 80856
Proximity Label-MS Homo sapiens
118 CHMP7 91782
Proximity Label-MS Homo sapiens
119 MIB1 57534
Proximity Label-MS Homo sapiens
120 SNAP47 116841
Proximity Label-MS Homo sapiens
121 CDKAL1  
Proximity Label-MS Homo sapiens
122 PBXIP1 57326
Proximity Label-MS Homo sapiens
123 YIF1A 10897
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
124 SLC9A1 6548
Proximity Label-MS Homo sapiens
125 TRPM7 54822
Proximity Label-MS Homo sapiens
126 JAG2  
Proximity Label-MS Homo sapiens
127 PREB 10113
Proximity Label-MS Homo sapiens
128 STX5 6811
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
129 TMEM131  
Proximity Label-MS Homo sapiens
130 ANO10 55129
Proximity Label-MS Homo sapiens
131 GOLGA5 9950
Proximity Label-MS Homo sapiens
132 SCD5  
Proximity Label-MS Homo sapiens
133 EMC8 10328
Proximity Label-MS Homo sapiens
134 ADCY9 115
Proximity Label-MS Homo sapiens
135 SLC27A4 10999
Proximity Label-MS Homo sapiens
136 TMEM128  
Two-hybrid Homo sapiens
137 FAM105A  
Two-hybrid Homo sapiens
138 ABHD12 26090
Proximity Label-MS Homo sapiens
139 SLC3A2 6520
Proximity Label-MS Homo sapiens
140 FAM134B 54463
Proximity Label-MS Homo sapiens
141 VRK2 7444
Proximity Label-MS Homo sapiens
142 DDRGK1 65992
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
143 TMEM209 84928
Proximity Label-MS Homo sapiens
144 LEMD3  
Proximity Label-MS Homo sapiens
145 LMNA 4000
Proximity Label-MS Homo sapiens
146 OSBPL8 114882
Proximity Label-MS Homo sapiens
147 GRAMD1B  
Proximity Label-MS Homo sapiens
148 SFRP4 6424
Two-hybrid Homo sapiens
149 SUN1 23353
Proximity Label-MS Homo sapiens
150 PLXNB2 23654
Proximity Label-MS Homo sapiens
151 SLC38A2 54407
Proximity Label-MS Homo sapiens
152 TRIM13  
Proximity Label-MS Homo sapiens
153 TMEM9 252839
Proximity Label-MS Homo sapiens
154 GOLT1A  
Two-hybrid Homo sapiens
155 PGRMC1 10857
Proximity Label-MS Homo sapiens
156 TMEM214 54867
Proximity Label-MS Homo sapiens
157 PEX19 5824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
158 PDCL 5082
Proximity Label-MS Homo sapiens
159 ARF5 381
Proximity Label-MS Homo sapiens
160 NSDHL 50814
Proximity Label-MS Homo sapiens
161 PIGU 128869
Proximity Label-MS Homo sapiens
162 TOR1AIP1 26092
Proximity Label-MS Homo sapiens
163 MMGT1 93380
Proximity Label-MS Homo sapiens
164 AUP1 550
Proximity Label-MS Homo sapiens
165 PLD3 23646
Proximity Label-MS Homo sapiens
166 ADIPOQ 9370
Two-hybrid Homo sapiens
167 ATP1A1 476
Proximity Label-MS Homo sapiens
168 TMEM109 79073
Proximity Label-MS Homo sapiens
169 YKT6 10652
Proximity Label-MS Homo sapiens
170 IGF2R 3482
Proximity Label-MS Homo sapiens
171 SMPD2 6610
Proximity Label-MS Homo sapiens
172 CKAP4 10970
Proximity Label-MS Homo sapiens
173 ANKRD46 157567
Two-hybrid Homo sapiens
174 ATP13A1 57130
Proximity Label-MS Homo sapiens
175 RAB23 51715
Proximity Label-MS Homo sapiens
176 NUPL2 11097
Proximity Label-MS Homo sapiens
177 SUCO  
Proximity Label-MS Homo sapiens
178 SLC30A8  
Two-hybrid Homo sapiens
179 CLCN7 1186
Proximity Label-MS Homo sapiens
180 DHCR24 1718
Proximity Label-MS Homo sapiens
181 CYB5B 80777
Proximity Label-MS Homo sapiens
182 NBAS 51594
Proximity Label-MS Homo sapiens
183 TMEM203  
Two-hybrid Homo sapiens
184 SYNE2 23224
Proximity Label-MS Homo sapiens
185 TMEM67 91147
Proximity Label-MS Homo sapiens
186 PTPN1 5770
Proximity Label-MS Homo sapiens
187 RTN4 57142
Proximity Label-MS Homo sapiens
188 TEX264 51368
Proximity Label-MS Homo sapiens
189 COPB2 9276
Affinity Capture-MS Homo sapiens
190 RHBDD2  
Proximity Label-MS Homo sapiens
191 PGS1 9489
Proximity Label-MS Homo sapiens
192 STX8 9482
Proximity Label-MS Homo sapiens
193 DSC2 1824
Proximity Label-MS Homo sapiens
194 LSG1  
Proximity Label-MS Homo sapiens
195 SSR1 6745
Proximity Label-MS Homo sapiens
196 SYNE3 161176
Proximity Label-MS Homo sapiens
197 CCDC47 57003
Proximity Label-MS Homo sapiens
198 MXRA7 439921
Proximity Label-MS Homo sapiens
199 MTDH 92140
Proximity Label-MS Homo sapiens
200 IL13RA2 3598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
201 ESYT2 57488
Proximity Label-MS Homo sapiens
202 CLGN 1047
Proximity Label-MS Homo sapiens
203 GBA2  
Proximity Label-MS Homo sapiens
204 NUP155 9631
Proximity Label-MS Homo sapiens
205 EIF2AK3  
Proximity Label-MS Homo sapiens
206 SCFD1 23256
Proximity Label-MS Homo sapiens
207 TMEM14B  
Two-hybrid Homo sapiens
208 CANT1 124583
Proximity Label-MS Homo sapiens
209 BNIP1 662
Two-hybrid Homo sapiens
210 REEP4  
Proximity Label-MS Homo sapiens
211 COPE 11316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
212 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
213 C6orf47  
Proximity Label-MS Homo sapiens
214 NTRK1 4914
Affinity Capture-MS Homo sapiens
215 OSBPL2 9885
Proximity Label-MS Homo sapiens
216 GPR182  
Affinity Capture-MS Homo sapiens
217 TACC1 6867
Proximity Label-MS Homo sapiens
218 RAB3GAP1 22930
Proximity Label-MS Homo sapiens
219 C17orf62 79415
Two-hybrid Homo sapiens
220 LIFR 3977
Proximity Label-MS Homo sapiens
221 SLC4A7 9497
Proximity Label-MS Homo sapiens
222 SMCR8 140775
Proximity Label-MS Homo sapiens
223 SPTLC1 10558
Affinity Capture-MS Homo sapiens
224 ITPR2 3709
Proximity Label-MS Homo sapiens
225 ATF6  
Proximity Label-MS Homo sapiens
226 LMNB2 84823
Proximity Label-MS Homo sapiens
227 VAMP3 9341
Proximity Label-MS Homo sapiens
228 STIM1 6786
Proximity Label-MS Homo sapiens
229 FBXO6 26270
Affinity Capture-MS Homo sapiens
230 HDAC11  
Affinity Capture-MS Homo sapiens
231 VAMP2 6844
Proximity Label-MS Homo sapiens
232 OCIAD1 54940