Gene description for SLC30A6
Gene name solute carrier family 30 (zinc transporter), member 6
Gene symbol SLC30A6
Other names/aliases MST103
MSTP103
ZNT6
Species Homo sapiens
 Database cross references - SLC30A6
ExoCarta ExoCarta_55676
Vesiclepedia VP_55676
Entrez Gene 55676
HGNC 19305
MIM 611148
UniProt Q6NXT4  
 SLC30A6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC30A6
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IDA
    protein binding GO:0005515 IPI
    zinc:proton antiporter activity GO:0140826 IDA
Biological Process
    zinc ion transport GO:0006829 IBA
    regulation of zinc ion transport GO:0071579 IDA
    zinc ion import into Golgi lumen GO:1904257 IDA
Subcellular Localization
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    trans-Golgi network membrane GO:0032588 IDA
 Experiment description of studies that identified SLC30A6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC30A6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TPRA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 STX6 10228
Proximity Label-MS Homo sapiens
3 ST8SIA3  
Affinity Capture-MS Homo sapiens
4 HDGFRP3 50810
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 RAB9A 9367
Proximity Label-MS Homo sapiens
6 GJD3  
Proximity Label-MS Homo sapiens
7 SLC17A2  
Affinity Capture-MS Homo sapiens
8 TMEM63C  
Affinity Capture-MS Homo sapiens
9 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
10 CSGALNACT2 55454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TMED10 10972
Affinity Capture-MS Homo sapiens
12 C12orf43  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 EBAG9 9166
Proximity Label-MS Homo sapiens
14 RIC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 OCLN 100506658
Proximity Label-MS Homo sapiens
16 GPR17 2840
Affinity Capture-MS Homo sapiens
17 BTNL9  
Affinity Capture-MS Homo sapiens
18 LAMTOR1 55004
Proximity Label-MS Homo sapiens
19 METTL7A 25840
Proximity Label-MS Homo sapiens
20 LAMP3  
Proximity Label-MS Homo sapiens
21 RAB1B 81876
Affinity Capture-MS Homo sapiens
22 GJA1 2697
Proximity Label-MS Homo sapiens
23 NUP155 9631
Proximity Label-MS Homo sapiens
24 RAB4A 5867
Proximity Label-MS Homo sapiens
25 DOK6  
Two-hybrid Homo sapiens
26 RNF128  
Affinity Capture-MS Homo sapiens
27 LAMP1 3916
Proximity Label-MS Homo sapiens
28 B3GNT3 10331
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 MYO18A 399687
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 LCK 3932
Proximity Label-MS Homo sapiens
31 HSD3B7 80270
Proximity Label-MS Homo sapiens
32 ACTBL2 345651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CD79B 974
Affinity Capture-MS Homo sapiens
34 HSD17B11 51170
Proximity Label-MS Homo sapiens
35 EMD 2010
Proximity Label-MS Homo sapiens
36 LAMP2 3920
Proximity Label-MS Homo sapiens
37 ACTB 60
Affinity Capture-MS Homo sapiens
38 CXADR 1525
Proximity Label-MS Homo sapiens
39 SLC24A3  
Affinity Capture-MS Homo sapiens
40 ERGIC1 57222
Proximity Label-MS Homo sapiens
41 KCNE3  
Affinity Capture-MS Homo sapiens
42 ARF4 378
Proximity Label-MS Homo sapiens
43 P2RY2 5029
Affinity Capture-MS Homo sapiens
44 GORASP1 64689
Proximity Label-MS Homo sapiens
45 FUT3 2525
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 GOLGA2 2801
Proximity Label-MS Homo sapiens
47 ERGIC2 51290
Proximity Label-MS Homo sapiens
48 B3GALT5  
Affinity Capture-MS Homo sapiens
49 CHRNA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 RAB2A 5862
Proximity Label-MS Homo sapiens
51 Uso1 56041
Affinity Capture-MS Mus musculus
52 B3GAT1  
Proximity Label-MS Homo sapiens
53 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SPECC1L 23384
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 RAB7A 7879
Proximity Label-MS Homo sapiens
56 RAB11A 8766
Proximity Label-MS Homo sapiens
57 GPR182  
Affinity Capture-MS Homo sapiens
58 AMFR 267
Affinity Capture-MS Homo sapiens
59 DTX2 113878
Proximity Label-MS Homo sapiens
60 TMPRSS3  
Affinity Capture-MS Homo sapiens
61 RAB3B 5865
Proximity Label-MS Homo sapiens
62 C5AR1  
Affinity Capture-MS Homo sapiens
63 SYVN1 84447
Affinity Capture-MS Homo sapiens
64 TMED7 51014
Affinity Capture-MS Homo sapiens
65 AVPR2  
Affinity Capture-MS Homo sapiens
66 KIR2DL4  
Affinity Capture-MS Homo sapiens
67 KCNA2  
Affinity Capture-MS Homo sapiens
68 RAB5C 5878
Proximity Label-MS Homo sapiens
69 NIPAL1  
Affinity Capture-MS Homo sapiens
70 METTL9 51108
Affinity Capture-MS Homo sapiens
71 NUP35 129401
Proximity Label-MS Homo sapiens
72 NTSR1  
Affinity Capture-MS Homo sapiens
73 SLC22A4 6583
Affinity Capture-MS Homo sapiens
74 PIGH  
Affinity Capture-MS Homo sapiens
75 PMEL 6490
Affinity Capture-MS Homo sapiens
76 CAV1 857
Proximity Label-MS Homo sapiens
77 ELOVL5 60481
Proximity Label-MS Homo sapiens
78 GORASP2 26003
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 C3orf52  
Affinity Capture-MS Homo sapiens
81 RAB1A 5861
Affinity Capture-MS Homo sapiens
82 KCNA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 SLC30A5 64924
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
84 ITFG3 83986
Affinity Capture-MS Homo sapiens
85 SLC25A46 91137
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLC30A6 is involved
No pathways found





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