Gene description for SLC30A5
Gene name solute carrier family 30 (zinc transporter), member 5
Gene symbol SLC30A5
Other names/aliases ZNT5
ZNTL1
ZTL1
ZnT-5
Species Homo sapiens
 Database cross references - SLC30A5
ExoCarta ExoCarta_64924
Vesiclepedia VP_64924
Entrez Gene 64924
HGNC 19089
MIM 607819
UniProt Q8TAD4  
 SLC30A5 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC30A5
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IBA
    zinc ion transmembrane transporter activity GO:0005385 IDA
    zinc ion transmembrane transporter activity GO:0005385 TAS
    protein binding GO:0005515 IPI
    cadmium ion transmembrane transporter activity GO:0015086 IDA
    antiporter activity GO:0015297 IEA
    zinc efflux transmembrane transporter activity GO:0022883 IDA
    metal ion binding GO:0046872 IEA
    zinc:proton antiporter activity GO:0140826 IDA
Biological Process
    GPI anchor biosynthetic process GO:0006506 IMP
    cobalt ion transport GO:0006824 IDA
    zinc ion transport GO:0006829 IDA
    zinc ion transport GO:0006829 IDA
    intracellular zinc ion homeostasis GO:0006882 IBA
    intracellular zinc ion homeostasis GO:0006882 IDA
    response to zinc ion GO:0010043 IDA
    insulin processing GO:0030070 TAS
    zinc ion import into organelle GO:0062111 IDA
    zinc ion import into organelle GO:0062111 IMP
    zinc ion transmembrane transport GO:0071577 TAS
    zinc ion import across plasma membrane GO:0071578 IDA
    zinc ion import into Golgi lumen GO:1904257 IBA
    zinc ion import into Golgi lumen GO:1904257 IDA
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    Golgi membrane GO:0000139 TAS
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IDA
    ER to Golgi transport vesicle membrane GO:0012507 IDA
    membrane GO:0016020 IDA
    apical plasma membrane GO:0016324 IDA
    apical plasma membrane GO:0016324 IEA
    secretory granule GO:0030141 IDA
    secretory granule membrane GO:0030667 IDA
    secretory granule membrane GO:0030667 TAS
    cytoplasmic vesicle GO:0031410 IBA
    trans-Golgi network membrane GO:0032588 IDA
    Golgi cis cisterna membrane GO:1990674 IDA
 Experiment description of studies that identified SLC30A5 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC30A5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CRELD1 78987
Affinity Capture-MS Homo sapiens
2 TPRA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TMEM129  
Affinity Capture-MS Homo sapiens
4 ABCC2 1244
Co-fractionation Homo sapiens
5 NT5E 4907
Co-fractionation Homo sapiens
6 HNRNPD 3184
Co-fractionation Homo sapiens
7 C5AR1  
Affinity Capture-MS Homo sapiens
8 SCIN 85477
Affinity Capture-MS Homo sapiens
9 CSGALNACT2 55454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TMED10 10972
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CYB5B 80777
Affinity Capture-MS Homo sapiens
12 C1orf158  
Affinity Capture-MS Homo sapiens
13 EBAG9 9166
Proximity Label-MS Homo sapiens
14 RIC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 RAB1A 5861
Affinity Capture-MS Homo sapiens
16 NTSR1  
Affinity Capture-MS Homo sapiens
17 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 KRTCAP2 200185
Affinity Capture-MS Homo sapiens
19 BTNL9  
Affinity Capture-MS Homo sapiens
20 LAMP3  
Proximity Label-MS Homo sapiens
21 OPALIN  
Affinity Capture-MS Homo sapiens
22 CD79B 974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 NUP155 9631
Proximity Label-MS Homo sapiens
24 CX3CL1  
Affinity Capture-MS Homo sapiens
25 RNF128  
Affinity Capture-MS Homo sapiens
26 LAMP1 3916
Proximity Label-MS Homo sapiens
27 SRSF1 6426
Co-fractionation Homo sapiens
28 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 B3GNT3 10331
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SLC30A6 55676
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
31 METTL9 51108
Affinity Capture-MS Homo sapiens
32 P2RY2 5029
Affinity Capture-MS Homo sapiens
33 HSD3B7 80270
Proximity Label-MS Homo sapiens
34 MDFI  
Affinity Capture-MS Homo sapiens
35 DPEP1 1800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 GJD3  
Proximity Label-MS Homo sapiens
37 LAMP2 3920
Proximity Label-MS Homo sapiens
38 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
39 VAMP2 6844
Co-fractionation Homo sapiens
40 CYB5D2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 HCRTR2  
Affinity Capture-MS Homo sapiens
42 CLEC4C  
Affinity Capture-MS Homo sapiens
43 GJA1 2697
Proximity Label-MS Homo sapiens
44 TMEM74  
Affinity Capture-MS Homo sapiens
45 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 IL1R2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 FUT3 2525
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TCIRG1 10312
Co-fractionation Homo sapiens
49 GPR12  
Affinity Capture-MS Homo sapiens
50 ERGIC2 51290
Proximity Label-MS Homo sapiens
51 CHRNA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 RAB2A 5862
Proximity Label-MS Homo sapiens
53 IL2RA  
Affinity Capture-MS Homo sapiens
54 IPPK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 B3GNT7  
Affinity Capture-MS Homo sapiens
56 B3GAT1  
Proximity Label-MS Homo sapiens
57 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 RAB7A 7879
Proximity Label-MS Homo sapiens
59 GORASP2 26003
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 SLC24A3  
Affinity Capture-MS Homo sapiens
61 EPHA2 1969
Proximity Label-MS Homo sapiens
62 CLPSL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 TMED7 51014
Affinity Capture-MS Homo sapiens
64 KIR2DL4  
Affinity Capture-MS Homo sapiens
65 ATP6V1B1 525
Co-fractionation Homo sapiens
66 NIPAL1  
Affinity Capture-MS Homo sapiens
67 ATP6V0A1 535
Co-fractionation Homo sapiens
68 CCR6  
Affinity Capture-MS Homo sapiens
69 CD83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 DNM2 1785
Co-fractionation Homo sapiens
71 S1PR4  
Affinity Capture-MS Homo sapiens
72 SLC22A4 6583
Affinity Capture-MS Homo sapiens
73 RAB5C 5878
Proximity Label-MS Homo sapiens
74 SEC62 7095
Affinity Capture-MS Homo sapiens
75 GPR17 2840
Affinity Capture-MS Homo sapiens
76 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 ATP6V1E1 529
Co-fractionation Homo sapiens
78 NUCKS1 64710
Affinity Capture-MS Homo sapiens
79 ITFG3 83986
Affinity Capture-MS Homo sapiens
80 AVPR2  
Affinity Capture-MS Homo sapiens
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