Gene description for FUT3
Gene name fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
Gene symbol FUT3
Other names/aliases CD174
FT3B
FucT-III
LE
Les
Species Homo sapiens
 Database cross references - FUT3
ExoCarta ExoCarta_2525
Vesiclepedia VP_2525
Entrez Gene 2525
HGNC 4014
MIM 111100
UniProt P21217  
 FUT3 identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for FUT3
Molecular Function
    protein binding GO:0005515 IPI
    fucosyltransferase activity GO:0008417 IDA
    3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity GO:0017060 IDA
    3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity GO:0017060 IMP
    3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity GO:0017060 TAS
    4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity GO:0017083 IDA
    4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity GO:0017083 IMP
    alpha-(1->3)-fucosyltransferase activity GO:0046920 IBA
    alpha-(1->3)-fucosyltransferase activity GO:0046920 IDA
    alpha-(1->3)-fucosyltransferase activity GO:0046920 TAS
Biological Process
    protein N-linked glycosylation GO:0006487 IDA
    protein O-linked glycosylation GO:0006493 IDA
    ceramide metabolic process GO:0006672 IDA
    oligosaccharide metabolic process GO:0009311 IDA
    oligosaccharide biosynthetic process GO:0009312 IDA
    oligosaccharide biosynthetic process GO:0009312 TAS
    cell-cell recognition GO:0009988 IC
    positive regulation of cell-cell adhesion GO:0022409 IMP
    regulation of cell migration GO:0030334 IMP
    fucosylation GO:0036065 IBA
    fucosylation GO:0036065 IDA
    regulation of cell population proliferation GO:0042127 IMP
    macromolecule glycosylation GO:0043413 IDA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    membrane GO:0016020 IDA
    Golgi cisterna membrane GO:0032580 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified FUT3 in sEVs
1
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for FUT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TOR3A 64222
Affinity Capture-MS Homo sapiens
2 RHBDD1 84236
Affinity Capture-MS Homo sapiens
3 CACNA2D1 781
Affinity Capture-MS Homo sapiens
4 TXNDC15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TUSC5  
Two-hybrid Homo sapiens
6 ZDHHC17 23390
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SLC30A6 55676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CNNM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 GLB1L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 FAM3B 54097
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
11 ECE1 1889
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 FKBP14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 GALNT12 79695
Affinity Capture-MS Homo sapiens
14 ADAMTS2 9509
Affinity Capture-MS Homo sapiens
15 ATP5G1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 WWP2 11060
Biochemical Activity Homo sapiens
17 HAPLN3 145864
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 C1QL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 SLC41A2 84102
Two-hybrid Homo sapiens
20 HLA-F 3134
Affinity Capture-MS Homo sapiens
21 SEC22A  
Two-hybrid Homo sapiens
22 FAM8A1 51439
Affinity Capture-MS Homo sapiens
23 HYAL2 8692
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 LMF2 91289
Affinity Capture-MS Homo sapiens
25 C3orf52  
Two-hybrid Homo sapiens
26 SLC30A5 64924
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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