Gene description for WWP2
Gene name WW domain containing E3 ubiquitin protein ligase 2
Gene symbol WWP2
Other names/aliases AIP2
WWp2-like
Species Homo sapiens
 Database cross references - WWP2
ExoCarta ExoCarta_11060
Vesiclepedia VP_11060
Entrez Gene 11060
HGNC 16804
MIM 602308
UniProt O00308  
 WWP2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
Mesenchymal stem cells 36408942    
Prostate cancer cells 25844599    
 Gene ontology annotations for WWP2
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    ubiquitin-protein transferase activity GO:0004842 IMP
    protein binding GO:0005515 IPI
    transcription factor binding GO:0008134 IPI
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IBA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 ISS
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 TAS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    transcription by RNA polymerase II GO:0006366 IEA
    extracellular transport GO:0006858 IMP
    negative regulation of gene expression GO:0010629 IMP
    protein ubiquitination GO:0016567 IDA
    protein ubiquitination GO:0016567 IDA
    protein ubiquitination GO:0016567 IMP
    negative regulation of transporter activity GO:0032410 IDA
    regulation of monoatomic ion transmembrane transport GO:0034765 IBA
    regulation of monoatomic ion transmembrane transport GO:0034765 IDA
    protein modification process GO:0036211 TAS
    regulation of membrane potential GO:0042391 IDA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IMP
    negative regulation of DNA-binding transcription factor activity GO:0043433 ISS
    negative regulation of Notch signaling pathway GO:0045746 TAS
    negative regulation of DNA-templated transcription GO:0045892 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    symbiont entry into host cell GO:0046718 TAS
    negative regulation of protein transport GO:0051224 IMP
    protein autoubiquitination GO:0051865 IDA
    protein K63-linked ubiquitination GO:0070534 ISS
    regulation of potassium ion transmembrane transporter activity GO:1901016 IDA
Subcellular Localization
    ubiquitin ligase complex GO:0000151 TAS
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified WWP2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for WWP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Csnk1d  
Affinity Capture-MS Mus musculus
2 EIF3A 8661
Affinity Capture-Western Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
4 CDC34 997
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
5 SMARCB1 6598
Affinity Capture-MS Homo sapiens
6 FAM131B  
Biochemical Activity Homo sapiens
7 NOTCH3 4854
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
8 POLR2G 5436
Affinity Capture-MS Homo sapiens
9 UBAP1 51271
Biochemical Activity Homo sapiens
10 EEF1G 1937
Affinity Capture-MS Homo sapiens
11 SCNN1A  
Reconstituted Complex Homo sapiens
12 DHRS7B 25979
Affinity Capture-MS Homo sapiens
13 DDX17 10521
Affinity Capture-MS Homo sapiens
14 TRAF4 9618
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 RAD23A 5886
Biochemical Activity Homo sapiens
16 PKM 5315
Affinity Capture-MS Homo sapiens
17 WASF2 10163
Biochemical Activity Homo sapiens
18 SQSTM1 8878
Biochemical Activity Homo sapiens
19 FMR1 2332
Affinity Capture-MS Homo sapiens
20 YWHAE 7531
Affinity Capture-MS Homo sapiens
21 TMEM127  
Affinity Capture-Western Homo sapiens
22 MKNK2 2872
Affinity Capture-MS Homo sapiens
23 USP9X 8239
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SMARCD3  
Affinity Capture-MS Homo sapiens
25 UBC 7316
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
26 FAM168A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 EIF4A1 1973
Affinity Capture-MS Homo sapiens
28 SMARCD1 6602
Affinity Capture-MS Homo sapiens
29 RASD1  
Two-hybrid Homo sapiens
30 CFL1 1072
Affinity Capture-MS Homo sapiens
31 SMARCC1 6599
Affinity Capture-MS Homo sapiens
32 ATN1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
33 VASP 7408
Two-hybrid Homo sapiens
34 LGALS9B 284194
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
35 RPAP3 79657
Affinity Capture-MS Homo sapiens
36 AMOTL1 154810
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 GYS1 2997
Affinity Capture-MS Homo sapiens
38 LZTS3  
Affinity Capture-MS Homo sapiens
39 KHDRBS3  
Biochemical Activity Homo sapiens
40 LONP2 83752
Affinity Capture-MS Homo sapiens
41 SART3 9733
Affinity Capture-MS Homo sapiens
42 WDR76  
Affinity Capture-MS Homo sapiens
43 SMR3A  
Two-hybrid Homo sapiens
44 DPM1 8813
Affinity Capture-MS Homo sapiens
45 PC 5091
Affinity Capture-MS Homo sapiens
46 UBE2E2  
Two-hybrid Homo sapiens
47 USP6NL 9712
Affinity Capture-MS Homo sapiens
48 HSPA5 3309
Affinity Capture-MS Homo sapiens
49 UBE2K 3093
Reconstituted Complex Homo sapiens
50 DAZAP1 26528
Affinity Capture-MS Homo sapiens
51 POLR2I 5438
Affinity Capture-MS Homo sapiens
52 TAB3 257397
Affinity Capture-MS Homo sapiens
53 BRCC3 79184
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
54 HGS 9146
Biochemical Activity Homo sapiens
55 CPSF7 79869
Affinity Capture-MS Homo sapiens
56 NPM1 4869
Affinity Capture-MS Homo sapiens
57 STAT3 6774
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
58 SNRPC 6631
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
59 POU5F1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
60 CALCOCO2  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
61 TRIP10 9322
Biochemical Activity Homo sapiens
62 EWSR1 2130
Two-hybrid Homo sapiens
63 SMARCA4 6597
Affinity Capture-MS Homo sapiens
64 TOM1 10043
Biochemical Activity Homo sapiens
65 OTUD7B 56957
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 ADARB1 104
Affinity Capture-Western Homo sapiens
67 ARID1A 8289
Affinity Capture-MS Homo sapiens
68 SCN5A 6331
Reconstituted Complex Homo sapiens
69 YLPM1 56252
Affinity Capture-MS Homo sapiens
70 RC3H1 149041
Affinity Capture-MS Homo sapiens
71 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
72 DGCR2 9993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 PTPN14 5784
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 POLR2C 5432
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 LDLRAD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 GPN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 CUL1 8454
Affinity Capture-MS Homo sapiens
78 POLR2M  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 WBP2 23558
Protein-peptide Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 USP7 7874
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
81 CEP131 22994
Affinity Capture-MS Homo sapiens
82 SMARCA2 6595
Affinity Capture-MS Homo sapiens
83 MCAM 4162
Proximity Label-MS Homo sapiens
84 TULP4 56995
Affinity Capture-MS Homo sapiens
85 DVL2 1856
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
86 FAF1 11124
Biochemical Activity Homo sapiens
87 RNF11 26994
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
88 DDX58 23586
Affinity Capture-RNA Homo sapiens
89 SMARCD2 6603
Affinity Capture-MS Homo sapiens
90 GPN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 TMEM255A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 WWP1 11059
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
93 WIPF1 7456
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
94 NDFIP1 80762
Affinity Capture-MS Homo sapiens
95 FARSA 2193
Affinity Capture-MS Homo sapiens
96 UBE2E3 10477
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
97 AMOTL2 51421
Affinity Capture-MS Homo sapiens
98 UBQLN4 56893
Biochemical Activity Homo sapiens
99 PIP 5304
Affinity Capture-MS Homo sapiens
100 ATP5A1 498
Affinity Capture-MS Homo sapiens
101 UBQLN1 29979
Biochemical Activity Homo sapiens
102 ARRDC1 92714
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 PSMD4 5710
Biochemical Activity Homo sapiens
104 UBAP2 55833
Affinity Capture-MS Homo sapiens
105 WBP1  
Protein-peptide Homo sapiens
106 UBE2D4  
Biochemical Activity Homo sapiens
107 EGR2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
108 ARID1B 57492
Affinity Capture-MS Homo sapiens
109 AGK 55750
Affinity Capture-MS Homo sapiens
110 BRE 9577
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 FBXO11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 OPTN 10133
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
113 PRKAG1 5571
Affinity Capture-MS Homo sapiens
114 DNAJC5 80331
Proximity Label-MS Homo sapiens
115 BAG6 7917
Affinity Capture-MS Homo sapiens
116 LAPTM5 7805
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
117 UBE2I 7329
Biochemical Activity Homo sapiens
118 SEC24D 9871
Two-hybrid Homo sapiens
119 PABPC1 26986
Affinity Capture-Western Homo sapiens
120 UBP1 7342
Affinity Capture-MS Homo sapiens
121 CCDC85C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 ARRDC2  
Affinity Capture-MS Homo sapiens
123 NTRK1 4914
Affinity Capture-MS Homo sapiens
124 USP5 8078
Biochemical Activity Homo sapiens
125 SMAD3 4088
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
126 BAG4  
Affinity Capture-MS Homo sapiens
127 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
128 EEF2 1938
Affinity Capture-MS Homo sapiens
129 DNAJA1 3301
Affinity Capture-MS Homo sapiens
130 SMAD2 4087
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
131 ARRDC3 57561
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
132 POLR2E 5434
Affinity Capture-MS Homo sapiens
133 ENO1 2023
Affinity Capture-MS Homo sapiens
134 MED25  
Two-hybrid Homo sapiens
135 UBE2D3 7323
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
136 Bmpr1a  
Affinity Capture-MS Mus musculus
137 TGM3 7053
Affinity Capture-MS Homo sapiens
138 ANKRD44 91526
Two-hybrid Homo sapiens
139 PPM1G 5496
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
140 TOM1L2 146691
Biochemical Activity Homo sapiens
141 VPS11 55823
Co-fractionation Homo sapiens
142 SLC25A5 292
Affinity Capture-MS Homo sapiens
143 SMARCC2 6601
Affinity Capture-MS Homo sapiens
144 POLR2B 5431
Affinity Capture-MS Homo sapiens
145 POLR2J  
Affinity Capture-MS Homo sapiens
146 DDX5 1655
Affinity Capture-MS Homo sapiens
147 SCNN1G  
Reconstituted Complex Homo sapiens
148 RECQL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
149 MARCH3 115123
Affinity Capture-MS Homo sapiens
150 S1PR1 1901
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
151 OLA1 29789
Affinity Capture-MS Homo sapiens
152 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
153 MCCC2 64087
Affinity Capture-MS Homo sapiens
154 ARRDC4  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
155 NDFIP2 54602
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
156 Ndfip1  
Affinity Capture-Western Mus musculus
157 CDK5RAP1  
Affinity Capture-MS Homo sapiens
158 SNRPB 6628
Two-hybrid Homo sapiens
159 RNF128  
Affinity Capture-MS Homo sapiens
160 UBE2L3 7332
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
161 CTNNB1 1499
Affinity Capture-MS Homo sapiens
162 PRKAA2 5563
Two-hybrid Homo sapiens
163 UBE2L6 9246
Affinity Capture-MS Homo sapiens
164 TJP1 7082
Affinity Capture-MS Homo sapiens
165 SF1 7536
Two-hybrid Homo sapiens
166 PTEN 5728
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
167 THBS1 7057
Biochemical Activity Homo sapiens
168 TNK2 10188
Reconstituted Complex Homo sapiens
169 UBE2E1  
Reconstituted Complex Homo sapiens
170 ARF1 375
Affinity Capture-MS Homo sapiens
171 GADD45GIP1  
Two-hybrid Homo sapiens
172 XRN2 22803
Affinity Capture-MS Homo sapiens
173 HNRNPUL1 11100
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
174 UACA 55075
Affinity Capture-MS Homo sapiens
175 TP73  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
176 RPRD1B 58490
Affinity Capture-MS Homo sapiens
177 NXF1 10482
Affinity Capture-RNA Homo sapiens
178 FUT3 2525
Biochemical Activity Homo sapiens
179 STRAP 11171
Affinity Capture-MS Homo sapiens
180 PRMT5 10419
Affinity Capture-MS Homo sapiens
181 UBE2D2 7322
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
182 POLR2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
183 PCBP1 5093
Affinity Capture-MS Homo sapiens
184 PSMD10 5716
Affinity Capture-Western Homo sapiens
185 TMEM132A 54972
Affinity Capture-MS Homo sapiens
186 FAM175B 23172
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
187 YWHAQ 10971
Affinity Capture-MS Homo sapiens
188 WDR5 11091
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
189 RUNX2  
Affinity Capture-Western Homo sapiens
190 USP24 23358
Affinity Capture-MS Homo sapiens
191 NLRP1  
Affinity Capture-MS Homo sapiens
192 HSPA1A 3303
Affinity Capture-MS Homo sapiens
193 EEF1A2 1917
Affinity Capture-MS Homo sapiens
194 FIP1L1 81608
Affinity Capture-MS Homo sapiens
195 UBTD1 80019
Two-hybrid Homo sapiens
196 UBL7  
Biochemical Activity Homo sapiens
197 UBE2J2 118424
Reconstituted Complex Homo sapiens
198 AMOT 154796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 DIDO1  
Two-hybrid Homo sapiens
200 GAS2L2  
Two-hybrid Homo sapiens
201 SMAD6  
Affinity Capture-MS Homo sapiens
202 CSDE1 7812
Affinity Capture-MS Homo sapiens
203 MAP3K7  
Affinity Capture-MS Homo sapiens
204 SH3D19 152503
Affinity Capture-MS Homo sapiens
205 UBAC1 10422
Biochemical Activity Homo sapiens
206 POLR2A 5430
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
207 SFMBT1 51460
Biochemical Activity Homo sapiens
208 SIRT1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
209 EFCAB3 146779
Two-hybrid Homo sapiens
210 SOX2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
211 DHX9 1660
Affinity Capture-MS Homo sapiens
212 UBE2D1 7321
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
213 PAIP1 10605
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
214 BRAF  
Affinity Capture-Western Homo sapiens
215 RBM14 10432
Affinity Capture-MS Homo sapiens
216 FBXL15  
Affinity Capture-Western Homo sapiens
217 NUDT21 11051
Affinity Capture-MS Homo sapiens
218 PDLIM7 9260
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
219 TMEM51 55092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
220 DVL1 1855
Affinity Capture-MS Homo sapiens
221 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
222 TP53BP2  
Affinity Capture-MS Homo sapiens
223 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
224 LTF 4057
Affinity Capture-MS Homo sapiens
225 TP53 7157
Affinity Capture-MS Homo sapiens
226 Sod1 20655
Affinity Capture-MS Mus musculus
227 SMAD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
228 CPSF6 11052
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
229 GGN  
Two-hybrid Homo sapiens
230 C3orf70  
Biochemical Activity Homo sapiens
231 FAM131C  
Biochemical Activity Homo sapiens
232 VPS37C 55048
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
233 MED4 29079
Biochemical Activity Homo sapiens
234 POLR2L 5441
Affinity Capture-MS Homo sapiens
235 PPP2R2A 5520
Affinity Capture-MS Homo sapiens
236 DDX3X 1654
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
237 PRRC2A 7916
Affinity Capture-MS Homo sapiens
238 RAD23B 5887
Biochemical Activity Homo sapiens
239 CFAP36 112942
Biochemical Activity Homo sapiens
240 LITAF 9516
Affinity Capture-Western Homo sapiens
241 RPAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
242 G3BP1 10146
Affinity Capture-MS Homo sapiens
243 ITCH 83737
Affinity Capture-MS Homo sapiens
244 CCT2 10576
Affinity Capture-MS Homo sapiens
245 G3BP2 9908
Affinity Capture-MS Homo sapiens
246 EIF4A3 9775
Affinity Capture-MS Homo sapiens
247 PDCD6IP 10015
Affinity Capture-Western Homo sapiens
248 TMLHE 55217
Affinity Capture-MS Homo sapiens
249 SCNN1B 6338
Far Western Homo sapiens
Reconstituted Complex Homo sapiens
250 HNRNPK 3190
Affinity Capture-MS Homo sapiens
251 LATS1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
252 SFTPC  
Reconstituted Complex Homo sapiens
253 BABAM1 29086
Affinity Capture-MS Homo sapiens
254 DNAJA2 10294
Affinity Capture-MS Homo sapiens
255 WWP2 11060
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
256 PPP1R13B  
Affinity Capture-MS Homo sapiens
257 MOV10 4343
Affinity Capture-RNA Homo sapiens
258 EZH2  
Affinity Capture-MS Homo sapiens
259 HNRNPL 3191
Affinity Capture-Western Homo sapiens
260 SUPT6H 6830
Affinity Capture-MS Homo sapiens
261 IST1 9798
Biochemical Activity Homo sapiens
262 USP15 9958
Affinity Capture-MS Homo sapiens
263 RUSC1  
Two-hybrid Homo sapiens
264 SORT1 6272
Affinity Capture-MS Homo sapiens
265 PCCB 5096
Affinity Capture-MS Homo sapiens
266 HIST1H4J 8363
Affinity Capture-MS Homo sapiens
267 FBXL18 80028
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
268 HNRNPF 3185
Affinity Capture-MS Homo sapiens
269 SPG20 23111
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
270 FAM189A2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
271 SERBP1 26135
Affinity Capture-MS Homo sapiens
272 TXNIP 10628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
273 OPA6  
Affinity Capture-MS Homo sapiens
274 DNAJC1 64215
Proximity Label-MS Homo sapiens
275 GNB2L1 10399
Affinity Capture-MS Homo sapiens
276 PCNA 5111
Affinity Capture-MS Homo sapiens
277 MYC  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
278 ATXN3 4287
Biochemical Activity Homo sapiens
279 UBE2G1 7326
Co-fractionation Homo sapiens
280 PTCH1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
281 SCAMP3 10067
Two-hybrid Homo sapiens
282 STAM 8027
Biochemical Activity Homo sapiens
283 Eea1  
Affinity Capture-MS Mus musculus
284 IFIT2 3433
Two-hybrid Homo sapiens
285 LAPTM4A 9741
Affinity Capture-MS Homo sapiens
286 RABEP2 79874
Biochemical Activity Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here