Gene description for WWP2
Gene name WW domain containing E3 ubiquitin protein ligase 2
Gene symbol WWP2
Other names/aliases AIP2
WWp2-like
Species Homo sapiens
 Database cross references - WWP2
ExoCarta ExoCarta_11060
Entrez Gene 11060
HGNC 16804
MIM 602308
UniProt O00308  
 WWP2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for WWP2
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IMP
    transcription factor binding GO:0008134 IPI
    RNA polymerase II transcription factor binding GO:0001085 ISS
    ligase activity GO:0016874 IEA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of transporter activity GO:0032410 IDA
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IBA
    protein autoubiquitination GO:0051865 IDA
    negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 ISS
    protein K63-linked ubiquitination GO:0070534 ISS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    protein ubiquitination GO:0016567 IDA
    regulation of potassium ion transmembrane transporter activity GO:1901016 IDA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IMP
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    cellular protein modification process GO:0006464 TAS
    regulation of ion transmembrane transport GO:0034765 IDA
    negative regulation of protein transport GO:0051224 IMP
    negative regulation of gene expression GO:0010629 IMP
    regulation of membrane potential GO:0042391 IDA
    viral entry into host cell GO:0046718 TAS
Subcellular Localization
    membrane GO:0016020 IDA
    extracellular exosome GO:0070062 IDA
    ubiquitin ligase complex GO:0000151 TAS
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified WWP2 in exosomes
1
Experiment ID 274
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for WWP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SCNN1B  
Reconstituted Complex Homo sapiens
2 SCNN1A  
Reconstituted Complex Homo sapiens
3 SCNN1G  
Reconstituted Complex Homo sapiens
4 PDLIM7 9260
Two-hybrid Homo sapiens
5 WBP2 23558
Protein-peptide Homo sapiens
6 SF1 7536
Two-hybrid Homo sapiens
7 EWSR1 2130
Two-hybrid Homo sapiens
8 DIDO1  
Two-hybrid Homo sapiens
9 WBP1  
Protein-peptide Homo sapiens
10 CPSF6 11052
Two-hybrid Homo sapiens
11 RNF11 26994
Affinity Capture-MS Homo sapiens
12 ATN1  
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
13 VASP 7408
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which WWP2 is involved
No pathways found





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