Gene description for CEP131
Gene name centrosomal protein 131kDa
Gene symbol CEP131
Other names/aliases AZ1
AZI1
ZA1
Species Homo sapiens
 Database cross references - CEP131
ExoCarta ExoCarta_22994
Entrez Gene 22994
HGNC 29511
MIM 613479
UniProt Q9UPN4  
 CEP131 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for CEP131
Molecular Function
    protein homodimerization activity GO:0042803 IDA
    protein complex binding GO:0032403 IDA
    molecular_function GO:0003674 ND
    protein binding GO:0005515 IPI
Biological Process
    spermatogenesis GO:0007283 IEA
    positive regulation of intracellular protein transport GO:0090316 IMP
    cell differentiation GO:0030154 IEA
    positive regulation of cell proliferation GO:0008284 IMP
    organelle organization GO:0006996 TAS
    G2/M transition of mitotic cell cycle GO:0000086 TAS
    multicellular organismal development GO:0007275 IEA
    intraciliary transport involved in cilium morphogenesis GO:0035735 IMP
    mitotic cell cycle GO:0000278 TAS
    regulation of centrosome duplication GO:0010824 IMP
Subcellular Localization
    intercellular bridge GO:0045171 IDA
    nucleus GO:0005634 IDA
    cilium GO:0005929 IMP
    centriole GO:0005814 IDA
    microtubule organizing center GO:0005815 IDA
    microtubule cytoskeleton GO:0015630 IDA
    nucleoplasm GO:0005654 IDA
    acrosomal vesicle GO:0001669 IEA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 TAS
    nuclear membrane GO:0031965 IDA
    centriolar satellite GO:0034451 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified CEP131 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CEP131
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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