Gene description for ANAPC2
Gene name anaphase promoting complex subunit 2
Gene symbol ANAPC2
Other names/aliases APC2
Species Homo sapiens
 Database cross references - ANAPC2
ExoCarta ExoCarta_29882
Vesiclepedia VP_29882
Entrez Gene 29882
HGNC 19989
MIM 606946
UniProt Q9UJX6  
 ANAPC2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
 Gene ontology annotations for ANAPC2
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin protein ligase binding GO:0031625 IEA
Biological Process
    metaphase/anaphase transition of mitotic cell cycle GO:0007091 IBA
    regulation of mitotic cell cycle GO:0007346 NAS
    nervous system development GO:0007399 IEA
    negative regulation of gene expression GO:0010629 IEA
    cell differentiation GO:0030154 IEA
    anaphase-promoting complex-dependent catabolic process GO:0031145 IDA
    anaphase-promoting complex-dependent catabolic process GO:0031145 NAS
    positive regulation of synaptic plasticity GO:0031915 ISS
    positive regulation of axon extension GO:0045773 IEA
    positive regulation of dendrite morphogenesis GO:0050775 IEA
    cell division GO:0051301 IEA
    regulation of meiotic cell cycle GO:0051445 NAS
    protein K48-linked ubiquitination GO:0070936 IDA
    protein K11-linked ubiquitination GO:0070979 IBA
    protein K11-linked ubiquitination GO:0070979 IDA
    positive regulation of synapse maturation GO:0090129 ISS
    protein branched polyubiquitination GO:0141198 IDA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    anaphase-promoting complex GO:0005680 IBA
    anaphase-promoting complex GO:0005680 IDA
    anaphase-promoting complex GO:0005680 IPI
    anaphase-promoting complex GO:0005680 NAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified ANAPC2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ANAPC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KIF16B 55614
Proximity Label-MS Homo sapiens
2 GRAP2 9402
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 AFG3L2 10939
Proximity Label-MS Homo sapiens
5 CDC26 246184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
6 DLG5 9231
Proximity Label-MS Homo sapiens
7 Cdk1 12534
Affinity Capture-MS Mus musculus
8 GEN1  
Proximity Label-MS Homo sapiens
9 KLC2 64837
Proximity Label-MS Homo sapiens
10 MPHOSPH9  
Proximity Label-MS Homo sapiens
11 BUB1  
Proximity Label-MS Homo sapiens
12 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
13 JADE3  
Proximity Label-MS Homo sapiens
14 LDHA 3939
Proximity Label-MS Homo sapiens
15 ANAPC5 51433
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ANAPC15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 APC  
Proximity Label-MS Homo sapiens
18 GAK 2580
Proximity Label-MS Homo sapiens
19 NUDCD3 23386
Proximity Label-MS Homo sapiens
20 PTTG1  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
21 BUB1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 THOC7 80145
Proximity Label-MS Homo sapiens
23 MYO5C 55930
Proximity Label-MS Homo sapiens
24 KIF7 374654
Proximity Label-MS Homo sapiens
25 COPA 1314
Proximity Label-MS Homo sapiens
26 PRKDC 5591
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 CEP97 79598
Proximity Label-MS Homo sapiens
28 PI4KA 5297
Proximity Label-MS Homo sapiens
29 UFD1L 7353
Two-hybrid Homo sapiens
30 TOMM22 56993
Proximity Label-MS Homo sapiens
31 CSPP1  
Proximity Label-MS Homo sapiens
32 CKB 1152
Proximity Label-MS Homo sapiens
33 FZR1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
34 CDC16 8881
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PCNT  
Proximity Label-MS Homo sapiens
36 CNOT10 25904
Proximity Label-MS Homo sapiens
37 ZNF408  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 DYRK1A 1859
Affinity Capture-MS Homo sapiens
39 NUDT19 390916
Proximity Label-MS Homo sapiens
40 DIAPH2  
Proximity Label-MS Homo sapiens
41 SMPD4 55627
Proximity Label-MS Homo sapiens
42 COPS5 10987
Affinity Capture-MS Homo sapiens
43 DRG1 4733
Proximity Label-MS Homo sapiens
44 FLII 2314
Proximity Label-MS Homo sapiens
45 CUX1 1523
Proximity Label-MS Homo sapiens
46 MDC1  
Affinity Capture-MS Homo sapiens
47 ETFA 2108
Proximity Label-MS Homo sapiens
48 OBSL1 23363
Proximity Label-MS Homo sapiens
49 SIRT1  
Affinity Capture-Western Homo sapiens
50 PSMC2 5701
Proximity Label-MS Homo sapiens
51 SRP14 6727
Affinity Capture-MS Homo sapiens
52 ANAPC11  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
53 STIP1 10963
Proximity Label-MS Homo sapiens
54 PEAK1 79834
Proximity Label-MS Homo sapiens
55 SRI 6717
Affinity Capture-MS Homo sapiens
56 CDC27 996
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
57 CCDC18  
Proximity Label-MS Homo sapiens
58 ANAPC7 51434
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
59 SPATA5L1 79029
Proximity Label-MS Homo sapiens
60 LRRC59 55379
Proximity Label-MS Homo sapiens
61 HSD17B4 3295
Proximity Label-MS Homo sapiens
62 ANAPC16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 WDR5 11091
Two-hybrid Homo sapiens
64 CEP131 22994
Proximity Label-MS Homo sapiens
65 MAD2L1 4085
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
66 Cdc20  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
67 PSMC3 5702
Affinity Capture-MS Homo sapiens
68 TEX9  
Proximity Label-MS Homo sapiens
69 KIF14 9928
Proximity Label-MS Homo sapiens
70 STUB1 10273
Proximity Label-MS Homo sapiens
71 NINL  
Affinity Capture-Western Homo sapiens
72 CCT2 10576
Proximity Label-MS Homo sapiens
73 RB1 5925
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
74 ALMS1  
Proximity Label-MS Homo sapiens
75 GRIA1  
Affinity Capture-Western Homo sapiens
76 FAM193A  
Proximity Label-MS Homo sapiens
77 Anapc5 59008
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
78 CDC23 8697
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 ABCE1 6059
Proximity Label-MS Homo sapiens
80 PKN2 5586
Proximity Label-MS Homo sapiens
81 PIBF1  
Proximity Label-MS Homo sapiens
82 ALDH1A2 8854
Proximity Label-MS Homo sapiens
83 KLC1 3831
Proximity Label-MS Homo sapiens
84 CEP192 55125
Proximity Label-MS Homo sapiens
85 CSTF2 1478
Proximity Label-MS Homo sapiens
86 KLC4 89953
Proximity Label-MS Homo sapiens
87 EXOC4 60412
Proximity Label-MS Homo sapiens
88 OFD1 8481
Proximity Label-MS Homo sapiens
89 GCC2 9648
Proximity Label-MS Homo sapiens
90 BRCA2 675
Proximity Label-MS Homo sapiens
91 CEP152  
Proximity Label-MS Homo sapiens
92 KIF5A 3798
Proximity Label-MS Homo sapiens
93 CDKAL1  
Proximity Label-MS Homo sapiens
94 ANKHD1 54882
Proximity Label-MS Homo sapiens
95 SDCCAG3  
Proximity Label-MS Homo sapiens
96 CCDC85C  
Proximity Label-MS Homo sapiens
97 SIPA1L2  
Proximity Label-MS Homo sapiens
98 ANAPC10  
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
99 TTLL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 TARS2 80222
Proximity Label-MS Homo sapiens
101 CCP110  
Proximity Label-MS Homo sapiens
102 PATL1 219988
Proximity Label-MS Homo sapiens
103 SMAD2 4087
Two-hybrid Homo sapiens
104 SPAG5 10615
Proximity Label-MS Homo sapiens
105 SMC1A 8243
Proximity Label-MS Homo sapiens
106 ANAPC4 29945
Co-purification Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 DNM2 1785
Proximity Label-MS Homo sapiens
108 PIK3C2A 5286
Proximity Label-MS Homo sapiens
109 LATS2 26524
Affinity Capture-Western Homo sapiens
110 ANKRD26 22852
Proximity Label-MS Homo sapiens
111 UCHL1 7345
Proximity Label-MS Homo sapiens
112 ATP5B 506
Proximity Label-MS Homo sapiens
113 FBXO5  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 ERC1 23085
Proximity Label-MS Homo sapiens
115 CACYBP 27101
Proximity Label-MS Homo sapiens
116 POLR2B 5431
Proximity Label-MS Homo sapiens
117 RGPD6  
Proximity Label-MS Homo sapiens
118 MTR 4548
Proximity Label-MS Homo sapiens
119 NCKAP5L  
Proximity Label-MS Homo sapiens
120 UBE2S  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
121 ANAPC13 25847
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 GOLGA3 2802
Proximity Label-MS Homo sapiens
123 RNF34  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
124 SYNJ2 8871
Proximity Label-MS Homo sapiens
125 Cdc23  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
126 SMARCAD1  
Affinity Capture-MS Homo sapiens
127 TP53BP1 7158
Affinity Capture-MS Homo sapiens
128 CSTF2T  
Proximity Label-MS Homo sapiens
129 C9orf78 51759
Affinity Capture-MS Homo sapiens
130 GLMN 11146
Proximity Label-MS Homo sapiens
131 SUGT1 10910
Proximity Label-MS Homo sapiens
132 ADCY9 115
Proximity Label-MS Homo sapiens
133 Gm9174  
Affinity Capture-MS Mus musculus
134 NPTN 27020
Affinity Capture-MS Homo sapiens
135 IQCB1  
Proximity Label-MS Homo sapiens
136 NUP88 4927
Proximity Label-MS Homo sapiens
137 CUL3 8452
Affinity Capture-MS Homo sapiens
138 TTC3 7267
Proximity Label-MS Homo sapiens
139 USP54 159195
Proximity Label-MS Homo sapiens
140 PYCR1 5831
Affinity Capture-MS Homo sapiens
141 FKBP8 23770
Proximity Label-MS Homo sapiens
142 PYCR2 29920
Affinity Capture-MS Homo sapiens
143 OCIAD1 54940
Proximity Label-MS Homo sapiens
144 Anapc16  
Affinity Capture-MS Mus musculus
145 Cdc16  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
146 CDK5RAP2 55755
Proximity Label-MS Homo sapiens
147 LZTS2 84445
Proximity Label-MS Homo sapiens
148 HAUS5 23354
Proximity Label-MS Homo sapiens
149 UBE2D2 7322
Reconstituted Complex Homo sapiens
150 CUL9  
Affinity Capture-MS Homo sapiens
151 SMG7  
Proximity Label-MS Homo sapiens
152 IST1 9798
Affinity Capture-Western Homo sapiens
153 FBXO43  
Affinity Capture-Western Homo sapiens
154 KIF11 3832
Proximity Label-MS Homo sapiens
155 CNTROB  
Proximity Label-MS Homo sapiens
156 FBXO2 26232
Affinity Capture-Western Homo sapiens
157 DNAJC7 7266
Proximity Label-MS Homo sapiens
158 DHPS 1725
Proximity Label-MS Homo sapiens
159 CABLES1  
Proximity Label-MS Homo sapiens
160 HSPA1A 3303
Proximity Label-MS Homo sapiens
161 RPAP3 79657
Proximity Label-MS Homo sapiens
162 NDC80 10403
Proximity Label-MS Homo sapiens
163 Anapc1  
Affinity Capture-MS Mus musculus
164 SIRT2 22933
Proximity Label-MS Homo sapiens
165 Bub1b 12236
Affinity Capture-MS Mus musculus
166 KIAA1671  
Proximity Label-MS Homo sapiens
167 SF3B3 23450
Proximity Label-MS Homo sapiens
168 CEP85  
Proximity Label-MS Homo sapiens
169 N4BP2  
Proximity Label-MS Homo sapiens
170 CEP350 9857
Proximity Label-MS Homo sapiens
171 MDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
172 HAUS4  
Proximity Label-MS Homo sapiens
173 KIF15 56992
Proximity Label-MS Homo sapiens
174 EIF2S1 1965
Proximity Label-MS Homo sapiens
175 ALG13 79868
Proximity Label-MS Homo sapiens
176 Anapc2  
Affinity Capture-MS Mus musculus
177 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
178 ALDH3A2 224
Proximity Label-MS Homo sapiens
179 TUBGCP2 10844
Proximity Label-MS Homo sapiens
180 CDC20 991
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
181 TTC1 7265
Proximity Label-MS Homo sapiens
182 TMEM57  
Proximity Label-MS Homo sapiens
183 DIAPH3 81624
Proximity Label-MS Homo sapiens
184 TP53 7157
Proximity Label-MS Homo sapiens
185 NELFCD 51497
Proximity Label-MS Homo sapiens
186 RGPD8  
Proximity Label-MS Homo sapiens
187 DNAJA2 10294
Proximity Label-MS Homo sapiens
188 EPHA4 2043
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
189 OSBPL11 114885
Proximity Label-MS Homo sapiens
190 CCDC138  
Proximity Label-MS Homo sapiens
191 SIPA1L3  
Proximity Label-MS Homo sapiens
192 TUBGCP3 10426
Proximity Label-MS Homo sapiens
193 SKP1 6500
Affinity Capture-MS Homo sapiens
194 ODF2L  
Proximity Label-MS Homo sapiens
195 LDHB 3945
Proximity Label-MS Homo sapiens
196 YARS 8565
Proximity Label-MS Homo sapiens
197 UBE2C 11065
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
198 ANAPC1 64682
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 FKBP4 2288
Proximity Label-MS Homo sapiens
200 CREBBP  
Affinity Capture-Western Homo sapiens
201 TTK 7272
Proximity Label-MS Homo sapiens
202 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
203 BIRC6 57448
Proximity Label-MS Homo sapiens
204 CCT7 10574
Affinity Capture-MS Homo sapiens
205 MAGIX 79917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
206 NUP107 57122
Proximity Label-MS Homo sapiens
207 NEK2  
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
208 EYA4 2070
Proximity Label-MS Homo sapiens
209 PFKM 5213
Proximity Label-MS Homo sapiens
210 CENPJ 55835
Proximity Label-MS Homo sapiens
211 KIAA0586  
Proximity Label-MS Homo sapiens
212 EIF2S3 1968
Proximity Label-MS Homo sapiens
213 POC5  
Proximity Label-MS Homo sapiens
214 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
215 EDRF1  
Proximity Label-MS Homo sapiens
216 TNRC6A 27327
Proximity Label-MS Homo sapiens
217 PSMC4 5704
Proximity Label-MS Homo sapiens
218 PHF8  
Affinity Capture-MS Homo sapiens
219 C16orf87 388272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
220 EP300 2033
Affinity Capture-Western Homo sapiens
221 CDC5L 988
Affinity Capture-MS Homo sapiens
222 Cdc26  
Affinity Capture-MS Mus musculus
223 CNDP2 55748
Proximity Label-MS Homo sapiens
224 IFT74 80173
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ANAPC2 is involved
PathwayEvidenceSource
Aberrant regulation of mitotic cell cycle due to RB1 defects TAS Reactome
Aberrant regulation of mitotic exit in cancer due to RB1 defects TAS Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
Adaptive Immune System TAS Reactome
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome
APC-Cdc20 mediated degradation of Nek2A TAS Reactome
APC/C-mediated degradation of cell cycle proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Cyclin B TAS Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Securin TAS Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 TAS Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
Autodegradation of Cdh1 by Cdh1:APC/C TAS Reactome
Cdc20:Phospho-APC/C mediated degradation of Cyclin A TAS Reactome
CDK-mediated phosphorylation and removal of Cdc6 TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase TAS Reactome
Disease TAS Reactome
Diseases of mitotic cell cycle TAS Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Immune System TAS Reactome
Inactivation of APC/C via direct inhibition of the APC/C complex TAS Reactome
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components TAS Reactome
M Phase TAS Reactome
Mitotic Anaphase TAS Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Mitotic Spindle Checkpoint TAS Reactome
Phosphorylation of the APC/C TAS Reactome
Regulation of APC/C activators between G1/S and early anaphase TAS Reactome
Regulation of mitotic cell cycle TAS Reactome
RNA Polymerase II Transcription TAS Reactome
S Phase TAS Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Separation of Sister Chromatids TAS Reactome
Switching of origins to a post-replicative state TAS Reactome
Synthesis of DNA TAS Reactome
Transcriptional Regulation by VENTX TAS Reactome





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