Gene description for SYNJ2
Gene name synaptojanin 2
Gene symbol SYNJ2
Other names/aliases INPP5H
Species Homo sapiens
 Database cross references - SYNJ2
ExoCarta ExoCarta_8871
Entrez Gene 8871
HGNC 11504
MIM 609410
UniProt O15056  
 SYNJ2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SYNJ2
Molecular Function
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 IEA
    RNA binding GO:0003723 IEA
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
Biological Process
    phosphatidylinositol dephosphorylation GO:0046856 IEA
    small molecule metabolic process GO:0044281 TAS
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    phospholipid metabolic process GO:0006644 TAS
Subcellular Localization
    membrane GO:0016020 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified SYNJ2 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SYNJ2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SYNJ2BP  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
2 SFN 2810
Affinity Capture-MS Homo sapiens
3 RAC1 5879
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 SH3GL2  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SYNJ2 is involved
PathwayEvidenceSource
Synthesis of PIPs at the plasma membrane TAS Reactome





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