Gene description for SYNJ2BP
Gene name synaptojanin 2 binding protein
Gene symbol SYNJ2BP
Other names/aliases ARIP2
OMP25
Species Homo sapiens
 Database cross references - SYNJ2BP
ExoCarta ExoCarta_55333
Vesiclepedia VP_55333
Entrez Gene 55333
HGNC 18955
MIM 609411
UniProt P57105  
 SYNJ2BP identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SYNJ2BP
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of endothelial cell proliferation GO:0001937 IMP
    protein targeting GO:0006605 IEA
    Rho protein signal transduction GO:0007266 IEA
    regulation of Notch signaling pathway GO:0008593 IMP
    negative regulation of endothelial cell migration GO:0010596 IMP
    negative regulation of angiogenesis GO:0016525 IMP
    regulation of endocytosis GO:0030100 IEA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IDA
    negative regulation of sprouting angiogenesis GO:1903671 IMP
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IDA
 Experiment description of studies that identified SYNJ2BP in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SYNJ2BP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STARD3NL 83930
Co-fractionation Homo sapiens
2 SLC10A6  
Two-hybrid Homo sapiens
3 QARS 5859
Affinity Capture-MS Homo sapiens
4 SYNGR1 9145
Affinity Capture-MS Homo sapiens
5 P4HA2 8974
Co-fractionation Homo sapiens
6 ADRB2  
Affinity Capture-MS Homo sapiens
7 TMEM184A  
Affinity Capture-MS Homo sapiens
8 SLC2A1 6513
Affinity Capture-MS Homo sapiens
9 KARS 3735
Affinity Capture-MS Homo sapiens
10 CD79A  
Two-hybrid Homo sapiens
11 TMEM72  
Affinity Capture-MS Homo sapiens
12 FFAR1  
Affinity Capture-MS Homo sapiens
13 APP 351
Reconstituted Complex Homo sapiens
14 TOMM22 56993
Co-fractionation Homo sapiens
15 LRP1 4035
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
16 VANGL2  
Affinity Capture-MS Homo sapiens
17 HSP90B2P  
Co-fractionation Homo sapiens
18 COQ9  
Affinity Capture-MS Homo sapiens
19 ELOVL7 79993
Two-hybrid Homo sapiens
20 SEL1L 6400
Co-fractionation Homo sapiens
21 HGS 9146
Co-fractionation Homo sapiens
22 GLMP 112770
Co-fractionation Homo sapiens
23 SLC25A12 8604
Co-fractionation Homo sapiens
24 GPR55  
Affinity Capture-MS Homo sapiens
25 ABCD3 5825
Co-fractionation Homo sapiens
26 GPBAR1  
Affinity Capture-MS Homo sapiens
27 PRDX2 7001
Co-fractionation Homo sapiens
28 ACVR2B  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
29 MEDAG  
Two-hybrid Homo sapiens
30 KPRP 448834
Co-fractionation Homo sapiens
31 ITFG3 83986
Co-fractionation Homo sapiens
32 TOMM40 10452
Co-fractionation Homo sapiens
33 F2RL1  
Affinity Capture-MS Homo sapiens
34 ABCC2 1244
Co-fractionation Homo sapiens
35 HK1 3098
Co-fractionation Homo sapiens
36 TFRC 7037
Co-fractionation Homo sapiens
37 PRNP 5621
Affinity Capture-MS Homo sapiens
38 WDR1 9948
Co-fractionation Homo sapiens
39 KCNK1  
Affinity Capture-MS Homo sapiens
40 DIO2  
Co-fractionation Homo sapiens
41 FCER1G 2207
Two-hybrid Homo sapiens
42 TMEM14B  
Two-hybrid Homo sapiens
43 SLC1A5 6510
Co-fractionation Homo sapiens
44 DPYSL4 10570
Affinity Capture-MS Homo sapiens
45 SDF2 6388
Co-fractionation Homo sapiens
46 MRPL45 84311
Co-fractionation Homo sapiens
47 REEP4  
Two-hybrid Homo sapiens
48 TMEM150A  
Affinity Capture-MS Homo sapiens
49 VSIG4  
Affinity Capture-MS Homo sapiens
50 RELL2  
Affinity Capture-MS Homo sapiens
51 ACTN4 81
Co-fractionation Homo sapiens
52 S1PR1 1901
Affinity Capture-MS Homo sapiens
53 SCAMP2 10066
Co-fractionation Homo sapiens
54 GPR182  
Affinity Capture-MS Homo sapiens
55 ZMPSTE24 10269
Co-fractionation Homo sapiens
56 ARHGAP19  
Co-fractionation Homo sapiens
57 TMEM56  
Two-hybrid Homo sapiens
58 FLOT2 2319
Affinity Capture-MS Homo sapiens
59 LHFPL5  
Two-hybrid Homo sapiens
60 LRP8 7804
Two-hybrid Homo sapiens
61 NT5E 4907
Co-fractionation Homo sapiens
62 ACTN1 87
Co-fractionation Homo sapiens
63 MRPL44  
Co-fractionation Homo sapiens
64 VIPR2  
Affinity Capture-MS Homo sapiens
65 CYB5B 80777
Co-fractionation Homo sapiens
66 SYNJ2 8871
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
67 THEM5  
Two-hybrid Homo sapiens
68 EGLN3  
Affinity Capture-MS Homo sapiens
69 AKAP14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 ERGIC3 51614
Two-hybrid Homo sapiens
71 P2RY2 5029
Affinity Capture-MS Homo sapiens
72 ACVR2A  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
73 DAD1 1603
Co-fractionation Homo sapiens
74 ATP1B3 483
Co-fractionation Homo sapiens
75 PRPSAP1 5635
Affinity Capture-MS Homo sapiens
76 CREB3L1  
Two-hybrid Homo sapiens
77 TMEM242  
Two-hybrid Homo sapiens
78 CDC42 998
Co-fractionation Homo sapiens
79 PROM1 8842
Co-fractionation Homo sapiens
80 GPR45  
Affinity Capture-MS Homo sapiens
81 CPLX4  
Two-hybrid Homo sapiens
82 OTULIN 90268
Affinity Capture-MS Homo sapiens
83 RRBP1 6238
Affinity Capture-MS Homo sapiens
84 USHBP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
85 ISLR 3671
Affinity Capture-MS Homo sapiens
86 CD55 1604
Co-fractionation Homo sapiens
87 TSC22D3  
Affinity Capture-MS Homo sapiens
88 THY1 7070
Co-fractionation Homo sapiens
89 FLOT1 10211
Affinity Capture-MS Homo sapiens
90 RALBP1 10928
Reconstituted Complex Homo sapiens
91 TARSL2 123283
Affinity Capture-MS Homo sapiens
92 MRPL42  
Affinity Capture-MS Homo sapiens
93 PRKCSH 5589
Co-fractionation Homo sapiens
94 SYNGR2 9144
Affinity Capture-MS Homo sapiens
95 TOR1AIP2 163590
Co-fractionation Homo sapiens
96 GP9 2815
Affinity Capture-MS Homo sapiens
97 ICT1 3396
Co-fractionation Homo sapiens
98 MFSD4  
Affinity Capture-MS Homo sapiens
99 M6PR 4074
Co-fractionation Homo sapiens
100 TSPAN15 23555
Affinity Capture-MS Homo sapiens
101 EBP  
Two-hybrid Homo sapiens
102 SHMT2 6472
Co-fractionation Homo sapiens
103 WIF1 11197
Affinity Capture-MS Homo sapiens
104 MGAT4B 11282
Co-fractionation Homo sapiens
105 TSC22D1 8848
Affinity Capture-MS Homo sapiens
106 STX3 6809
Co-fractionation Homo sapiens
107 LRP2 4036
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
108 GLIPR1L2  
Co-fractionation Homo sapiens
109 VIPR1  
Affinity Capture-MS Homo sapiens
110 VANGL1 81839
Affinity Capture-MS Homo sapiens
111 ESYT1 23344
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 FPR2  
Affinity Capture-MS Homo sapiens
113 TOMM5  
Co-fractionation Homo sapiens
114 FAM210B  
Two-hybrid Homo sapiens
115 S1PR4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SYNJ2BP is involved
No pathways found





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