Gene description for ELOVL7
Gene name ELOVL fatty acid elongase 7
Gene symbol ELOVL7
Other names/aliases -
Species Homo sapiens
 Database cross references - ELOVL7
ExoCarta ExoCarta_79993
Entrez Gene 79993
HGNC 26292
MIM 614451
UniProt A1L3X0  
 ELOVL7 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ELOVL7
Molecular Function
    transferase activity GO:0016740 IEA
    protein binding GO:0005515 IPI
Biological Process
    triglyceride biosynthetic process GO:0019432 TAS
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 TAS
    fatty acid elongation, saturated fatty acid GO:0019367 IDA
    fatty acid elongation, polyunsaturated fatty acid GO:0034626 IDA
    very long-chain fatty acid biosynthetic process GO:0042761 IDA
    cellular lipid metabolic process GO:0044255 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    endoplasmic reticulum GO:0005783 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified ELOVL7 in exosomes
1
Experiment ID 234
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ELOVL7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ELOVL7 is involved
PathwayEvidenceSource
Synthesis of very long-chain fatty acyl-CoAs TAS Reactome





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