Gene description for ELOVL7
Gene name ELOVL fatty acid elongase 7
Gene symbol ELOVL7
Other names/aliases -
Species Homo sapiens
 Database cross references - ELOVL7
ExoCarta ExoCarta_79993
Vesiclepedia VP_79993
Entrez Gene 79993
HGNC 26292
MIM 614451
UniProt A1L3X0  
 ELOVL7 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ELOVL7
Molecular Function
    protein binding GO:0005515 IPI
    fatty acid elongase activity GO:0009922 EXP
    fatty acid elongase activity GO:0009922 IBA
    fatty acid elongase activity GO:0009922 TAS
Biological Process
    unsaturated fatty acid biosynthetic process GO:0006636 IEA
    fatty acid elongation, saturated fatty acid GO:0019367 IBA
    fatty acid elongation, saturated fatty acid GO:0019367 IDA
    sphingolipid biosynthetic process GO:0030148 IBA
    fatty acid elongation, monounsaturated fatty acid GO:0034625 IBA
    fatty acid elongation, polyunsaturated fatty acid GO:0034626 IBA
    fatty acid elongation, polyunsaturated fatty acid GO:0034626 IDA
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 TAS
    very long-chain fatty acid biosynthetic process GO:0042761 IBA
    very long-chain fatty acid biosynthetic process GO:0042761 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified ELOVL7 in exosomes
1
Experiment ID 234
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ELOVL7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SERF1B  
Two-hybrid Homo sapiens
2 VAMP1 6843
Two-hybrid Homo sapiens
3 UBE2J2 118424
Two-hybrid Homo sapiens
4 EMR2  
Two-hybrid Homo sapiens
5 TMEM14C 51522
Two-hybrid Homo sapiens
6 CERS2 29956
Affinity Capture-Western Homo sapiens
7 DTNBP1  
Two-hybrid Homo sapiens
8 RTP2  
Two-hybrid Homo sapiens
9 ILF3 3609
Affinity Capture-RNA Homo sapiens
10 SYNJ2BP 55333
Two-hybrid Homo sapiens
11 SERF1A  
Two-hybrid Homo sapiens
12 EMP3 2014
Two-hybrid Homo sapiens
13 SLC41A1 254428
Two-hybrid Homo sapiens
14 CCDC47 57003
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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