Gene description for RALBP1
Gene name ralA binding protein 1
Gene symbol RALBP1
Other names/aliases RIP1
RLIP1
RLIP76
Species Homo sapiens
 Database cross references - RALBP1
ExoCarta ExoCarta_10928
Vesiclepedia VP_10928
Entrez Gene 10928
HGNC 9841
MIM 605801
UniProt Q15311  
 RALBP1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RALBP1
Molecular Function
    GTPase activator activity GO:0005096 IBA
    GTPase activator activity GO:0005096 IDA
    GTPase activator activity GO:0005096 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ABC-type xenobiotic transporter activity GO:0008559 IEA
    ABC-type glutathione S-conjugate transporter activity GO:0015431 IEA
    transmembrane transporter activity GO:0022857 IDA
    small GTPase binding GO:0031267 IPI
    ATPase-coupled transmembrane transporter activity GO:0042626 IDA
    ATPase-coupled transmembrane transporter activity GO:0042626 TAS
    xenobiotic transmembrane transporter activity GO:0042910 IDA
Biological Process
    positive regulation of protein phosphorylation GO:0001934 IMP
    receptor-mediated endocytosis GO:0006898 IBA
    chemotaxis GO:0006935 TAS
    small GTPase-mediated signal transduction GO:0007264 IBA
    small GTPase-mediated signal transduction GO:0007264 IPI
    regulation of Cdc42 protein signal transduction GO:0032489 ISS
    regulation of GTPase activity GO:0043087 IDA
    positive regulation of GTPase activity GO:0043547 IDA
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    transmembrane transport GO:0055085 IDA
    positive regulation of mitochondrial fission GO:0090141 IMP
    doxorubicin transport GO:1900753 IDA
    xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 IDA
Subcellular Localization
    spindle pole GO:0000922 IEA
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
    nuclear body GO:0016604 IDA
 Experiment description of studies that identified RALBP1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RALBP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZBTB38 253461
Two-hybrid Homo sapiens
2 AP2S1 1175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TNIP1 10318
Two-hybrid Homo sapiens
4 AP2B1 163
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 Cul1 26965
Affinity Capture-MS Mus musculus
6 AAK1 22848
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SKI 6497
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ALB 213
Affinity Capture-MS Homo sapiens
9 JUND 3727
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 AIM1L  
Affinity Capture-MS Homo sapiens
11 CALCOCO1 57658
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 KIF7 374654
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 HOOK2  
Two-hybrid Homo sapiens
14 SEPT2 4735
Affinity Capture-MS Homo sapiens
15 PPL 5493
Two-hybrid Homo sapiens
16 RNPS1 10921
Affinity Capture-MS Homo sapiens
17 GSE1 23199
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
18 AP2A1 160
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 CREBZF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TBRG1  
Two-hybrid Homo sapiens
21 CCDC6 8030
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CROCC 9696
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 GOPC 57120
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ATG16L1 55054
Affinity Capture-MS Homo sapiens
25 CEP57  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
26 SEPT7 989
Affinity Capture-MS Homo sapiens
27 GTSE1 51512
Affinity Capture-MS Homo sapiens
28 GTF3A 2971
Affinity Capture-Western Homo sapiens
29 C1orf216  
Two-hybrid Homo sapiens
30 TNF  
Affinity Capture-Western Homo sapiens
31 AMOTL2 51421
Two-hybrid Homo sapiens
32 KIFC1 3833
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 Pdlim5 56376
Affinity Capture-MS Mus musculus
34 RUFY1 80230
Affinity Capture-MS Homo sapiens
35 RALA 5898
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
36 RRAGB 10325
Affinity Capture-MS Homo sapiens
37 MAPRE1 22919
Affinity Capture-MS Homo sapiens
38 CCNB1 891
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
39 GCC1 79571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 NUMB 8650
Affinity Capture-Western Homo sapiens
41 SYNJ2BP 55333
Reconstituted Complex Homo sapiens
42 HMGN1  
Affinity Capture-MS Homo sapiens
43 TRAPPC2L 51693
Affinity Capture-MS Homo sapiens
44 AP1B1 162
Affinity Capture-MS Homo sapiens
45 CEP164  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 BMP2K 55589
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 REPS2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 ZNF784  
Affinity Capture-MS Homo sapiens
49 MYH11 4629
Affinity Capture-MS Homo sapiens
50 STAMBP 10617
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 PICALM 8301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 ANKRD26 22852
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 BIRC6 57448
Affinity Capture-MS Homo sapiens
54 GPS2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 PPP4R1 9989
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 GOLGA4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 RHOU 58480
Reconstituted Complex Homo sapiens
58 CLINT1 9685
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 SMARCE1 6605
Two-hybrid Homo sapiens
60 Prkcz  
Affinity Capture-MS Mus musculus
61 RBM47 54502
Affinity Capture-MS Homo sapiens
62 RALB 5899
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
63 CCDC82  
Affinity Capture-MS Homo sapiens
64 PHLDB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 HOOK3 84376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 TFPT  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
67 POLR2A 5430
Co-fractionation Homo sapiens
68 SLC25A41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 AP2M1 1173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 CDK5RAP2 55755
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 JUN 3725
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 CEP250 11190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 CBY1  
Affinity Capture-MS Homo sapiens
74 EPN3 55040
Affinity Capture-Western Homo sapiens
75 EPN1 29924
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
76 AP2A2 161
Affinity Capture-MS Homo sapiens
77 PSMC5 5705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 RHOB 388
Proximity Label-MS Homo sapiens
79 RUNDC3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 BIRC8  
Affinity Capture-MS Homo sapiens
81 HIP1R 9026
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 MSANTD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 DNAJC6  
Affinity Capture-MS Homo sapiens
84 DNAH6 1768
Cross-Linking-MS (XL-MS) Homo sapiens
85 ZNF707  
Two-hybrid Homo sapiens
86 TSFM 10102
Two-hybrid Homo sapiens
87 TRAF2 7186
Co-localization Homo sapiens
88 RBM25 58517
Co-fractionation Homo sapiens
89 LSR 51599
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 IKBKG 8517
Co-localization Homo sapiens
91 CASP8 841
Affinity Capture-Western Homo sapiens
92 SEPT10 151011
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 Numb  
Affinity Capture-MS Mus musculus
94 HDAC1 3065
Affinity Capture-MS Homo sapiens
95 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
96 EPN2 22905
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
97 CPSF2 53981
Co-fractionation Homo sapiens
98 SAPCD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 C10orf88  
Affinity Capture-MS Homo sapiens
100 REPS1 85021
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 HSF1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
102 PRKCA 5578
Biochemical Activity Homo sapiens
103 IFT43  
Affinity Capture-MS Homo sapiens
104 KRAS 3845
Proximity Label-MS Homo sapiens
105 RAC1 5879
Two-hybrid Homo sapiens
FRET Homo sapiens
View the network image/svg+xml



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