Gene description for RRAGB
Gene name Ras-related GTP binding B
Gene symbol RRAGB
Other names/aliases RAGB
bA465E19.1
Species Homo sapiens
 Database cross references - RRAGB
ExoCarta ExoCarta_10325
Entrez Gene 10325
HGNC 19901
MIM 300725
UniProt Q5VZM2  
 RRAGB identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Thymus 23844026    
 Gene ontology annotations for RRAGB
Molecular Function
    GTPase activity GO:0003924 IBA
    guanyl ribonucleotide binding GO:0032561 IDA
    GTP binding GO:0005525 IDA
    protein binding GO:0005515 IPI
Biological Process
    regulation of autophagy GO:0010506 IBA
    cellular protein localization GO:0034613 IMP
    cellular response to starvation GO:0009267 IBA
    metabolic process GO:0008152 IBA
    cellular response to amino acid stimulus GO:0071230 IMP
    positive regulation of TOR signaling GO:0032008 IMP
Subcellular Localization
    lysosomal membrane GO:0005765 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    EGO complex GO:0034448 IBA
    Gtr1-Gtr2 GTPase complex GO:1990131 IBA
    Golgi apparatus GO:0005794 IDA
    cytoplasm GO:0005737 IDA
    lysosome GO:0005764 IDA
 Experiment description of studies that identified RRAGB in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RRAGB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RRAGD 58528
Invivo Homo sapiens
2 RRAGC 64121
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which RRAGB is involved
No pathways found





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