Gene description for LAMTOR4
Gene name late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
Gene symbol LAMTOR4
Other names/aliases C7orf59
Species Homo sapiens
 Database cross references - LAMTOR4
ExoCarta ExoCarta_389541
Entrez Gene 389541
HGNC 33772
UniProt Q0VGL1  
 LAMTOR4 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for LAMTOR4
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    protein binding GO:0005515 IPI
    protein complex scaffold GO:0032947 IDA
Biological Process
    protein localization to lysosome GO:0061462 IMP
    cellular response to amino acid stimulus GO:0071230 IMP
    positive regulation of GTPase activity GO:0043547 IDA
    positive regulation of TOR signaling GO:0032008 IMP
    regulation of cell size GO:0008361 IMP
Subcellular Localization
    lysosome GO:0005764 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    Ragulator complex GO:0071986 IDA
 Experiment description of studies that identified LAMTOR4 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LAMTOR4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LAMTOR4 is involved
No pathways found





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