Gene description for SNCA
Gene name	synuclein, alpha (non A4 component of amyloid precursor)
Gene symbol	SNCA
Other names/aliases	NACP PARK1 PARK4 PD1
Species	Homo sapiens
Database cross references - SNCA
ExoCarta	ExoCarta_6622
Vesiclepedia	VP_6622
Entrez Gene	6622
HGNC	11138
MIM	163890
UniProt	P37840
SNCA identified in sEVs derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for SNCA

Molecular Function     SNARE binding GO:0000149 IDA     magnesium ion binding GO:0000287 IDA     transcription cis-regulatory region binding GO:0000976 TAS     actin binding GO:0003779 IPI     protein kinase inhibitor activity GO:0004860 TAS     fatty acid binding GO:0005504 IDA     copper ion binding GO:0005507 IDA     calcium ion binding GO:0005509 IDA     protein binding GO:0005515 IPI     phospholipid binding GO:0005543 IDA     ferrous iron binding GO:0008198 IDA     zinc ion binding GO:0008270 IDA     lipid binding GO:0008289 EXP     lipid binding GO:0008289 IDA     oxidoreductase activity GO:0016491 IDA     kinesin binding GO:0019894 IPI     Hsp70 protein binding GO:0030544 IPI     histone binding GO:0042393 IDA     identical protein binding GO:0042802 IDA     identical protein binding GO:0042802 IPI     alpha-tubulin binding GO:0043014 IPI     cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 IDA     tau protein binding GO:0048156 IDA     phosphoprotein binding GO:0051219 IDA     molecular adaptor activity GO:0060090 EXP     phospholipase D inhibitor activity GO:0060961 IDA     dynein complex binding GO:0070840 IPI     cuprous ion binding GO:1903136 IBA     cuprous ion binding GO:1903136 IMP Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 TAS     microglial cell activation GO:0001774 TAS     positive regulation of receptor recycling GO:0001921 IDA     positive regulation of neurotransmitter secretion GO:0001956 IEA     negative regulation of protein kinase activity GO:0006469 TAS     fatty acid metabolic process GO:0006631 IEA     neutral lipid metabolic process GO:0006638 IEA     phospholipid metabolic process GO:0006644 IEA     mitochondrial membrane organization GO:0007006 IEA     chemical synaptic transmission GO:0007268 IBA     adult locomotory behavior GO:0008344 IEA     response to xenobiotic stimulus GO:0009410 IEA     response to iron(II) ion GO:0010040 IDA     regulation of phospholipase activity GO:0010517 IDA     negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 IDA     regulation of glutamate secretion GO:0014048 IEA     regulation of dopamine secretion GO:0014059 TAS     synaptic vesicle exocytosis GO:0016079 IDA     synaptic vesicle priming GO:0016082 IMP     regulation of transmembrane transporter activity GO:0022898 IGI     negative regulation of microtubule polymerization GO:0031115 IDA     receptor internalization GO:0031623 IDA     protein destabilization GO:0031648 IDA     response to magnesium ion GO:0032026 IDA     negative regulation of transporter activity GO:0032410 IDA     response to lipopolysaccharide GO:0032496 IDA     negative regulation of monooxygenase activity GO:0032769 IDA     positive regulation of peptidyl-serine phosphorylation GO:0033138 ISS     response to type II interferon GO:0034341 IDA     cellular response to oxidative stress GO:0034599 IC     SNARE complex assembly GO:0035493 IDA     positive regulation of SNARE complex assembly GO:0035543 IDA     regulation of locomotion GO:0040012 IEA     dopamine biosynthetic process GO:0042416 TAS     mitochondrial ATP synthesis coupled electron transport GO:0042775 IEA     regulation of macrophage activation GO:0043030 IEA     positive regulation of apoptotic process GO:0043065 TAS     negative regulation of apoptotic process GO:0043066 IMP     negative regulation of neuron apoptotic process GO:0043524 IEA     positive regulation of endocytosis GO:0045807 IDA     negative regulation of exocytosis GO:0045920 IMP     positive regulation of exocytosis GO:0045921 IMP     regulation of long-term neuronal synaptic plasticity GO:0048169 IEA     synaptic vesicle endocytosis GO:0048488 IBA     synaptic vesicle endocytosis GO:0048488 ISS     synaptic vesicle transport GO:0048489 IEA     positive regulation of inflammatory response GO:0050729 IDA     synapse organization GO:0050808 IBA     regulation of acyl-CoA biosynthetic process GO:0050812 IEA     protein tetramerization GO:0051262 IDA     positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IDA     neuron apoptotic process GO:0051402 IEA     dopamine uptake involved in synaptic transmission GO:0051583 TAS     negative regulation of dopamine uptake involved in synaptic transmission GO:0051585 IDA     negative regulation of serotonin uptake GO:0051612 IDA     regulation of norepinephrine uptake GO:0051621 IGI     negative regulation of norepinephrine uptake GO:0051622 IDA     calcium ion homeostasis GO:0055074 IDA     excitatory postsynaptic potential GO:0060079 IEA     long-term synaptic potentiation GO:0060291 IEA     positive regulation of inositol phosphate biosynthetic process GO:0060732 IDA     negative regulation of thrombin-activated receptor signaling pathway GO:0070495 IDA     response to interleukin-1 GO:0070555 IDA     cellular response to copper ion GO:0071280 IDA     cellular response to epinephrine stimulus GO:0071872 TAS     positive regulation of protein serine/threonine kinase activity GO:0071902 IDA     supramolecular fiber organization GO:0097435 TAS     negative regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902957 TAS     positive regulation of glutathione peroxidase activity GO:1903284 IDA     positive regulation of hydrogen peroxide catabolic process GO:1903285 IDA     regulation of synaptic vesicle recycling GO:1903421 TAS     regulation of reactive oxygen species biosynthetic process GO:1903426 TAS     positive regulation of protein localization to cell periphery GO:1904377 IGI     negative regulation of chaperone-mediated autophagy GO:1904715 IMP     regulation of presynapse assembly GO:1905606 IGI     amyloid fibril formation GO:1990000 EXP Subcellular Localization     extracellular region GO:0005576 IDA     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IDA     nucleus GO:0005634 IDA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     mitochondrion GO:0005739 TAS     lysosome GO:0005764 TAS     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IDA     cell cortex GO:0005938 IDA     actin cytoskeleton GO:0015629 IDA     membrane GO:0016020 IDA     inclusion body GO:0016234 IDA     axon GO:0030424 IDA     growth cone GO:0030426 IDA     synaptic vesicle membrane GO:0030672 IEA     platelet alpha granule membrane GO:0031092 IDA     protein-containing complex GO:0032991 IMP     neuronal cell body GO:0043025 IBA     axon terminus GO:0043679 IBA     perinuclear region of cytoplasm GO:0048471 IDA     postsynapse GO:0098794 IEA     supramolecular fiber GO:0099512 IDA