Gene description for SNCA
Gene name	synuclein, alpha (non A4 component of amyloid precursor)
Gene symbol	SNCA
Other names/aliases	NACP PARK1 PARK4 PD1
Species	Homo sapiens
Database cross references - SNCA
ExoCarta	ExoCarta_6622
Entrez Gene	6622
HGNC	11138
MIM	163890
UniProt	P37840
SNCA identified in exosomes derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for SNCA

Molecular Function     microtubule binding GO:0008017 IEA     cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 IDA     phosphoprotein binding GO:0051219 IDA     zinc ion binding GO:0008270 IDA     dynein binding GO:0045502 IPI     beta-tubulin binding GO:0048487 IEA     transcription regulatory region DNA binding GO:0044212 TAS     identical protein binding GO:0042802 IPI     alpha-tubulin binding GO:0043014 IPI     tau protein binding GO:0048156 IDA     ferrous iron binding GO:0008198 IDA     oxidoreductase activity GO:0016491 IDA     histone binding GO:0042393 IDA     magnesium ion binding GO:0000287 IDA     protein binding GO:0005515 IPI     Hsp70 protein binding GO:0030544 IPI     kinesin binding GO:0019894 IPI     phospholipase D inhibitor activity GO:0060961 IDA     phospholipase binding GO:0043274 IEA     calcium ion binding GO:0005509 IDA     copper ion binding GO:0005507 IDA     protein N-terminus binding GO:0047485 IEA     fatty acid binding GO:0005504 IDA     phospholipid binding GO:0005543 IDA     protein domain specific binding GO:0019904 IEA Biological Process     regulation of excitatory postsynaptic membrane potential GO:0060079 IEA     oxidation-reduction process GO:0055114 IDA     dopamine biosynthetic process GO:0042416 TAS     positive regulation of receptor recycling GO:0001921 IDA     negative regulation of serotonin uptake GO:0051612 IDA     dopamine uptake involved in synaptic transmission GO:0051583 TAS     long-term synaptic potentiation GO:0060291 IEA     response to lipopolysaccharide GO:0032496 IDA     negative regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902957 TAS     regulation of reactive oxygen species biosynthetic process GO:1903426 TAS     behavioral response to cocaine GO:0048148 IEA     mitochondrial membrane organization GO:0007006 IEA     regulation of dopamine secretion GO:0014059 TAS     negative regulation of neuron apoptotic process GO:0043524 IEA     synapse organization GO:0050808 IEA     response to interleukin-1 GO:0070555 IDA     positive regulation of inositol phosphate biosynthetic process GO:0060732 IDA     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA     negative regulation of microtubule polymerization GO:0031115 IDA     extracellular fibril organization GO:0043206 TAS     negative regulation of thrombin receptor signaling pathway GO:0070495 IDA     positive regulation of neurotransmitter secretion GO:0001956 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 TAS     response to magnesium ion GO:0032026 IDA     negative regulation of dopamine uptake involved in synaptic transmission GO:0051585 IDA     response to drug GO:0042493 IEA     negative regulation of apoptotic process GO:0043066 IMP     positive regulation of glutathione peroxidase activity GO:1903284 IDA     cellular response to oxidative stress GO:0034599 IC     cellular response to fibroblast growth factor stimulus GO:0044344 IEA     positive regulation of protein serine/threonine kinase activity GO:0071902 IDA     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IMP     negative regulation of exocytosis GO:0045920 IMP     cellular response to copper ion GO:0071280 IDA     regulation of macrophage activation GO:0043030 IEA     regulation of locomotion GO:0040012 IEA     negative regulation of protein phosphorylation GO:0001933 IEA     regulation of synaptic vesicle recycling GO:1903421 TAS     positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IDA     microglial cell activation GO:0001774 TAS     regulation of acyl-CoA biosynthetic process GO:0050812 IEA     neutral lipid metabolic process GO:0006638 IEA     negative regulation of transporter activity GO:0032410 IDA     adult locomotory behavior GO:0008344 IEA     regulation of phospholipase activity GO:0010517 IDA     positive regulation of peptidyl-serine phosphorylation GO:0033138 ISS     aging GO:0007568 IEA     positive regulation of apoptotic process GO:0043065 TAS     regulation of glutamate secretion GO:0014048 IEA     calcium ion homeostasis GO:0055074 IDA     synaptic vesicle endocytosis GO:0048488 ISS     negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 IDA     protein destabilization GO:0031648 IDA     positive regulation of endocytosis GO:0045807 IDA     negative regulation of dopamine metabolic process GO:0045963 IEA     negative regulation of norepinephrine uptake GO:0051622 IDA     positive regulation of hydrogen peroxide catabolic process GO:1903285 IDA     cellular response to epinephrine stimulus GO:0071872 TAS     regulation of long-term neuronal synaptic plasticity GO:0048169 IEA     negative regulation of monooxygenase activity GO:0032769 IDA     negative regulation of histone acetylation GO:0035067 IDA     response to interferon-gamma GO:0034341 IDA     mitochondrial ATP synthesis coupled electron transport GO:0042775 IEA     response to iron(II) ion GO:0010040 IDA     receptor internalization GO:0031623 IDA     fatty acid metabolic process GO:0006631 IEA     phospholipid metabolic process GO:0006644 IEA Subcellular Localization     rough endoplasmic reticulum GO:0005791 IEA     mitochondrial respiratory chain complex I GO:0005747 TAS     Golgi apparatus GO:0005794 IEA     nucleus GO:0005634 IDA     extracellular space GO:0005615 IDA     platelet alpha granule membrane GO:0031092 IDA     extracellular region GO:0005576 TAS     cell junction GO:0030054 IEA     cell cortex GO:0005938 IDA     ribosome GO:0005840 IEA     synaptic vesicle GO:0008021 IEA     cytoplasm GO:0005737 IDA     lysosome GO:0005764 TAS     membrane GO:0016020 IDA     fibril GO:0043205 IDA     nuclear outer membrane GO:0005640 IEA     actin cytoskeleton GO:0015629 IDA     inclusion body GO:0016234 IDA     growth cone GO:0030426 IDA     mitochondrion GO:0005739 TAS     terminal bouton GO:0043195 IEA     plasma membrane GO:0005886 IDA     perinuclear region of cytoplasm GO:0048471 IDA     cytosol GO:0005829 IDA     axon GO:0030424 IDA