Gene description for Pld2
Gene name phospholipase D2
Gene symbol Pld2
Other names/aliases Pldc
Species Rattus norvegicus
 Database cross references - Pld2
ExoCarta ExoCarta_25097
Entrez Gene 25097
UniProt P70498  
 Pld2 identified in exosomes derived from the following tissue/cell type
Basophilic leukemia cells 15304316    
 Gene ontology annotations for Pld2
Molecular Function
    protein binding GO:0005515 IPI
    phospholipase D activity GO:0004630 ISO
    N-acylphosphatidylethanolamine-specific phospholipase D activity GO:0070290 IEA
    phosphatidylinositol binding GO:0035091 IEA
    protein kinase C binding GO:0005080 IPI
Biological Process
    response to hydrogen peroxide GO:0042542 IMP
    receptor-mediated endocytosis GO:0006898 ISO
    phospholipid catabolic process GO:0009395 IMP
    regulation of cell migration GO:0030334 IEA
    response to hypoxia GO:0001666 IDA
    positive regulation of cell migration GO:0030335 IMP
    positive regulation of cell adhesion GO:0045785 IMP
    G-protein coupled receptor internalization GO:0002031 ISO
    positive regulation of mast cell degranulation GO:0043306 IMP
    neuron projection development GO:0031175 IMP
    response to organic cyclic compound GO:0014070 IDA
    inositol lipid-mediated signaling GO:0048017 IEA
    positive regulation of receptor-mediated endocytosis GO:0048260 IMP
    regulation of phagocytosis GO:0050764 IEA
    response to peptide hormone GO:0043434 IMP
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IMP
    phosphatidic acid biosynthetic process GO:0006654 IEA
Subcellular Localization
    lamellipodium GO:0030027 IDA
    sarcolemma GO:0042383 IDA
    Golgi apparatus GO:0005794 IDA
    nucleus GO:0005634 IDA
    plasma membrane GO:0005886 ISO
    intracellular GO:0005622 IEA
    brush border membrane GO:0031526 ISO
    caveola GO:0005901 IDA
 Experiment description of studies that identified Pld2 in exosomes
1
Experiment ID 134
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 15304316    
Organism Rattus norvegicus
Experiment description PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes
Authors Laulagnier K, Grand D, Dujardin A, Hamdi S, Vincent-Schneider H, Lankar D, Salles JP, Bonnerot C, Perret B, Record M.
Journal name FL
Publication year 2004
Sample Basophilic leukemia cells
Sample name RBL-2H3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
FACS
 Protein-protein interactions for Pld2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Actb 81822
Affinity Capture-Western Rattus norvegicus
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Pld2 is involved
No pathways found





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