Gene description for Vdac2
Gene name voltage-dependent anion channel 2
Gene symbol Vdac2
Other names/aliases Vdac6
mVDAC2
mVDAC6
Species Mus musculus
 Database cross references - Vdac2
ExoCarta ExoCarta_22334
Entrez Gene 22334
UniProt Q60930  
 Vdac2 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Vdac2
Molecular Function
    nucleotide binding GO:0000166 IEA
    porin activity GO:0015288 IEA
    voltage-gated anion channel activity GO:0008308 IEA
    protein binding GO:0005515 IPI
Biological Process
    ion transport GO:0006811 IEA
    transport GO:0006810 IEA
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IMP
    anion transport GO:0006820 IEA
    regulation of anion transport GO:0044070 IEA
    negative regulation of protein polymerization GO:0032272 IMP
    transmembrane transport GO:0055085 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    mitochondrial inner membrane GO:0005743 IDA
    membrane raft GO:0045121 ISO
    mitochondrial outer membrane GO:0005741 IEA
    integral component of membrane GO:0016021 IEA
    myelin sheath GO:0043209 IDA
    mitochondrion GO:0005739 ISO
    membrane GO:0016020 IEA
    mitochondrial nucleoid GO:0042645 ISO
    pore complex GO:0046930 IEA
    extracellular exosome GO:0070062 ISO
    synaptic vesicle GO:0008021 ISO
 Experiment description of studies that identified Vdac2 in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Vdac2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Vdac2 is involved
No pathways found





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