Gene description for HSPB8
Gene name heat shock 22kDa protein 8
Gene symbol HSPB8
Other names/aliases CMT2L
DHMN2
E2IG1
H11
HMN2
HMN2A
HSP22
Species Homo sapiens
 Database cross references - HSPB8
ExoCarta ExoCarta_26353
Entrez Gene 26353
HGNC 30171
MIM 608014
UniProt Q9UJY1  
 HSPB8 identified in exosomes derived from the following tissue/cell type
Malignant ascites 12147373    
 Gene ontology annotations for HSPB8
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase activity GO:0004672 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    biological_process GO:0008150 ND
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    intracellular GO:0005622 IDA
    Golgi apparatus GO:0005794 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified HSPB8 in exosomes
1
Experiment ID 56
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
MHCI|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 12147373    
Organism Homo sapiens
Experiment description Malignant effusions and immunogenic tumour-derived exosomes.
Authors Andre F, Schartz NE, Movassagh M, Flament C, Pautier P, Morice P, Pomel C, Lhomme C, Escudier B, Le Chevalier T, Tursz T, Amigorena S, Raposo G, Angevin E, Zitvogel L
Journal name LANCET
Publication year 2002
Sample Malignant ascites
Sample name Malignant ascites
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for HSPB8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BAG3  
Two-hybrid Homo sapiens
2 HSPB8 26353
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 HSPB2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 HSPB1 3315
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
5 HSPB7  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which HSPB8 is involved
No pathways found





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