Gene description for APAF1
Gene name	apoptotic peptidase activating factor 1
Gene symbol	APAF1
Other names/aliases	APAF-1 CED4
Species	Homo sapiens
Database cross references - APAF1
ExoCarta	ExoCarta_317
Entrez Gene	317
HGNC	576
MIM	602233
UniProt	O14727
APAF1 identified in exosomes derived from the following tissue/cell type
Thymus	23844026
Urine	19056867

Gene ontology annotations for APAF1

Molecular Function     protein binding GO:0005515 IPI     identical protein binding GO:0042802 IEA     nucleotide binding GO:0000166 TAS     ATP binding GO:0005524 IEA     cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 NAS     ADP binding GO:0043531 IEA Biological Process     intrinsic apoptotic signaling pathway GO:0097193 TAS     activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 TAS     apoptotic process GO:0006915 TAS     regulation of apoptotic DNA fragmentation GO:1902510 IEA     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA     programmed cell death GO:0012501 TAS     positive regulation of apoptotic process GO:0043065 TAS     positive regulation of apoptotic signaling pathway GO:2001235 IEA     response to G1 DNA damage checkpoint signaling GO:0072432 TAS     forebrain development GO:0030900 IEA     neuron apoptotic process GO:0051402 IEA     neural tube closure GO:0001843 IEA     regulation of apoptotic process GO:0042981 TAS     nervous system development GO:0007399 TAS Subcellular Localization     cytosol GO:0005829 TAS     extracellular exosome GO:0070062 IDA     nucleus GO:0005634 IEA     apoptosome GO:0043293 TAS