Gene description for PLBD1
Gene name phospholipase B domain containing 1
Gene symbol PLBD1
Other names/aliases -
Species Homo sapiens
 Database cross references - PLBD1
ExoCarta ExoCarta_79887
Vesiclepedia VP_79887
Entrez Gene 79887
HGNC 26215
UniProt Q6P4A8  
 PLBD1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for PLBD1
Molecular Function
    hydrolase activity GO:0016787 IEA
Biological Process
    phosphatidylethanolamine acyl-chain remodeling GO:0036152 TAS
    phospholipid metabolic process GO:0006644 TAS
    phosphatidylinositol acyl-chain remodeling GO:0036149 TAS
    lipid catabolic process GO:0016042 IEA
    phosphatidylcholine acyl-chain remodeling GO:0036151 TAS
    glycerophospholipid biosynthetic process GO:0046474 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    lysosome GO:0005764 IEA
 Experiment description of studies that identified PLBD1 in exosomes
1
Experiment ID 1203
MISEV standards
✔
EM
EV Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ.
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for PLBD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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