Gene description for STX17
Gene name syntaxin 17
Gene symbol STX17
Other names/aliases -
Species Homo sapiens
 Database cross references - STX17
ExoCarta ExoCarta_55014
Vesiclepedia VP_55014
Entrez Gene 55014
HGNC 11432
MIM 604204
UniProt P56962  
 STX17 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for STX17
Molecular Function
    SNARE binding GO:0000149 IBA
    SNARE binding GO:0000149 IDA
    SNAP receptor activity GO:0005484 IBA
    SNAP receptor activity GO:0005484 IMP
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IEA
    protein phosphatase binding GO:0019903 IPI
Biological Process
    intracellular protein transport GO:0006886 IBA
    exocytosis GO:0006887 IBA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IMP
    vesicle fusion GO:0006906 IBA
    Golgi organization GO:0007030 IMP
    autophagosome membrane docking GO:0016240 IDA
    protein localization to phagophore assembly site GO:0034497 IDA
    vesicle docking GO:0048278 IBA
    endoplasmic reticulum-Golgi intermediate compartment organization GO:0097111 IMP
    autophagosome maturation GO:0097352 IDA
    autophagosome maturation GO:0097352 IMP
Subcellular Localization
    autophagosome membrane GO:0000421 IBA
    autophagosome membrane GO:0000421 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 IDA
    lysosomal membrane GO:0005765 IDA
    autophagosome GO:0005776 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    rough endoplasmic reticulum GO:0005791 IDA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IDA
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 IBA
    endomembrane system GO:0012505 IBA
    ER to Golgi transport vesicle membrane GO:0012507 IEA
    COPII-coated ER to Golgi transport vesicle GO:0030134 ISS
    smooth endoplasmic reticulum membrane GO:0030868 ISS
    HOPS complex GO:0030897 IDA
    SNARE complex GO:0031201 IBA
    SNARE complex GO:0031201 IDA
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 IEA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 IDA
 Experiment description of studies that identified STX17 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for STX17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Affinity Capture-MS Homo sapiens
2 MVP 9961
Affinity Capture-MS Homo sapiens
3 HMOX1 3162
Affinity Capture-MS Homo sapiens
4 MAP1LC3C  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 C5AR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 VPS41 27072
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 SNX3 8724
Affinity Capture-MS Homo sapiens
8 SERPINB4 6318
Affinity Capture-MS Homo sapiens
9 AKR1B10 57016
Affinity Capture-MS Homo sapiens
10 YOD1  
Affinity Capture-MS Homo sapiens
11 EML2 24139
Affinity Capture-MS Homo sapiens
12 CPM 1368
Affinity Capture-MS Homo sapiens
13 CMTM8  
Affinity Capture-MS Homo sapiens
14 PSME2 5721
Affinity Capture-MS Homo sapiens
15 SH3GL1 6455
Affinity Capture-MS Homo sapiens
16 IL36G 56300
Affinity Capture-MS Homo sapiens
17 ALB 213
Affinity Capture-MS Homo sapiens
18 SERPINB13 5275
Affinity Capture-MS Homo sapiens
19 CMPK1 51727
Affinity Capture-MS Homo sapiens
20 MPO 4353
Affinity Capture-MS Homo sapiens
21 SLC2A1 6513
Affinity Capture-MS Homo sapiens
22 FAM129B 64855
Affinity Capture-MS Homo sapiens
23 KIF20A 10112
Affinity Capture-MS Homo sapiens
24 IL36RN  
Affinity Capture-MS Homo sapiens
25 HBB 3043
Affinity Capture-MS Homo sapiens
26 VWA5A 4013
Affinity Capture-MS Homo sapiens
27 KNG1 3827
Affinity Capture-MS Homo sapiens
28 AZGP1 563
Affinity Capture-MS Homo sapiens
29 FFAR1  
Affinity Capture-MS Homo sapiens
30 PSMB8 5696
Affinity Capture-MS Homo sapiens
31 CPA4 51200
Affinity Capture-MS Homo sapiens
32 HAL 3034
Affinity Capture-MS Homo sapiens
33 HPX 3263
Affinity Capture-MS Homo sapiens
34 KIF13B 23303
Affinity Capture-MS Homo sapiens
35 PPL 5493
Affinity Capture-MS Homo sapiens
36 CLIC3 9022
Affinity Capture-MS Homo sapiens
37 HP 3240
Affinity Capture-MS Homo sapiens
38 GLTP 51228
Affinity Capture-MS Homo sapiens
39 TSTA3 7264
Affinity Capture-MS Homo sapiens
40 CAPG 822
Affinity Capture-MS Homo sapiens
41 NDRG1 10397
Affinity Capture-MS Homo sapiens
42 CARKD 55739
Affinity Capture-MS Homo sapiens
43 C3 718
Affinity Capture-MS Homo sapiens
44 IQGAP1 8826
Affinity Capture-MS Homo sapiens
45 DUSP14 11072
Affinity Capture-MS Homo sapiens
46 ACPP 55
Affinity Capture-MS Homo sapiens
47 BBOX1 8424
Affinity Capture-MS Homo sapiens
48 STAT3 6774
Affinity Capture-MS Homo sapiens
49 GPBAR1  
Affinity Capture-MS Homo sapiens
50 NT5C3A 51251
Affinity Capture-MS Homo sapiens
51 HIST2H3PS2 440686
Affinity Capture-MS Homo sapiens
52 SERPINB1 1992
Affinity Capture-MS Homo sapiens
53 FLG 2312
Affinity Capture-MS Homo sapiens
54 TREX2  
Affinity Capture-MS Homo sapiens
55 DSG3 1830
Affinity Capture-MS Homo sapiens
56 KPRP 448834
Affinity Capture-MS Homo sapiens
57 ENDOU  
Affinity Capture-MS Homo sapiens
58 A2M 2
Affinity Capture-MS Homo sapiens
59 NAGK 55577
Affinity Capture-MS Homo sapiens
60 SERPINA1 5265
Affinity Capture-MS Homo sapiens
61 VPS16 64601
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
62 PAPL  
Affinity Capture-MS Homo sapiens
63 EHD1 10938
Affinity Capture-MS Homo sapiens
64 ARHGDIB 397
Affinity Capture-MS Homo sapiens
65 CTSV 1515
Affinity Capture-MS Homo sapiens
66 FAS 355
Proximity Label-MS Homo sapiens
67 HEPHL1  
Affinity Capture-MS Homo sapiens
68 RDH12 145226
Affinity Capture-MS Homo sapiens
69 LCP1 3936
Affinity Capture-MS Homo sapiens
70 POF1B 79983
Affinity Capture-MS Homo sapiens
71 KCTD4  
Affinity Capture-MS Homo sapiens
72 PLBD1 79887
Affinity Capture-MS Homo sapiens
73 SCEL 8796
Affinity Capture-MS Homo sapiens
74 RAB14 51552
Affinity Capture-MS Homo sapiens
75 HMGCS1 3157
Affinity Capture-MS Homo sapiens
76 ORM1 5004
Affinity Capture-MS Homo sapiens
77 FGA 2243
Affinity Capture-MS Homo sapiens
78 SBSN 374897
Affinity Capture-MS Homo sapiens
79 SLC2A8 29988
Affinity Capture-MS Homo sapiens
80 RAB5B 5869
Affinity Capture-MS Homo sapiens
81 ANXA3 306
Affinity Capture-MS Homo sapiens
82 CAST 831
Affinity Capture-MS Homo sapiens
83 PTK6  
Affinity Capture-MS Homo sapiens
84 EPS8L2 64787
Affinity Capture-MS Homo sapiens
85 GDPD3 79153
Affinity Capture-MS Homo sapiens
86 AIM1 202
Affinity Capture-MS Homo sapiens
87 FGG 2266
Affinity Capture-MS Homo sapiens
88 TPRG1  
Affinity Capture-MS Homo sapiens
89 IGHG1 3500
Affinity Capture-MS Homo sapiens
90 S1PR1 1901
Affinity Capture-MS Homo sapiens
91 SERPINB8 5271
Affinity Capture-MS Homo sapiens
92 EYA3  
Affinity Capture-MS Homo sapiens
93 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
94 TGM5  
Affinity Capture-MS Homo sapiens
95 EVPL 2125
Affinity Capture-MS Homo sapiens
96 GSDMC  
Affinity Capture-MS Homo sapiens
97 TGM1 7051
Affinity Capture-MS Homo sapiens
98 MIS18A  
Two-hybrid Homo sapiens
99 STX5 6811
Co-purification Homo sapiens
100 SERPINB7 8710
Affinity Capture-MS Homo sapiens
101 CAPN1 823
Affinity Capture-MS Homo sapiens
102 ACOX1 51
Affinity Capture-MS Homo sapiens
103 SERPINA3 12
Affinity Capture-MS Homo sapiens
104 H2AFY 9555
Affinity Capture-MS Homo sapiens
105 VPS18 57617
Affinity Capture-Western Homo sapiens
106 MAPK13 5603
Affinity Capture-MS Homo sapiens
107 TMCO3 55002
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 CTNNBIP1 56998
Affinity Capture-MS Homo sapiens
109 VPS11 55823
Affinity Capture-Western Homo sapiens
110 IGHM 3507
Affinity Capture-MS Homo sapiens
111 CLDN10  
Affinity Capture-MS Homo sapiens
112 SNAP29 9342
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
113 SQRDL 58472
Affinity Capture-MS Homo sapiens
114 EPX 8288
Affinity Capture-MS Homo sapiens
115 CALML3 810
Affinity Capture-MS Homo sapiens
116 BCAP31 10134
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
117 CASP14 23581
Affinity Capture-MS Homo sapiens
118 IMPA2 3613
Affinity Capture-MS Homo sapiens
119 SERPINB3 6317
Affinity Capture-MS Homo sapiens
120 APLNR  
Affinity Capture-MS Homo sapiens
121 IVL 3713
Affinity Capture-MS Homo sapiens
122 IGLC2 3538
Affinity Capture-MS Homo sapiens
123 AIFM1 9131
Affinity Capture-MS Homo sapiens
124 TYMP 1890
Affinity Capture-MS Homo sapiens
125 PPM1E  
Affinity Capture-MS Homo sapiens
126 IL1RN 3557
Affinity Capture-MS Homo sapiens
127 PITHD1 57095
Affinity Capture-MS Homo sapiens
128 CRYAB 1410
Affinity Capture-MS Homo sapiens
129 MYH14 79784
Affinity Capture-MS Homo sapiens
130 RAB25 57111
Affinity Capture-MS Homo sapiens
131 IGKC 3514
Affinity Capture-MS Homo sapiens
132 EPPK1 83481
Affinity Capture-MS Homo sapiens
133 MGARP  
Affinity Capture-MS Homo sapiens
134 DSG1 1828
Affinity Capture-MS Homo sapiens
135 S100A7 6278
Affinity Capture-MS Homo sapiens
136 CP 1356
Affinity Capture-MS Homo sapiens
137 CD207  
Affinity Capture-MS Homo sapiens
138 S100A7A 338324
Affinity Capture-MS Homo sapiens
139 AQP3  
Affinity Capture-MS Homo sapiens
140 ATG14  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
141 HIP1R 9026
Affinity Capture-MS Homo sapiens
142 SERPINB5 5268
Affinity Capture-MS Homo sapiens
143 A2ML1 144568
Affinity Capture-MS Homo sapiens
144 C4A 720
Affinity Capture-MS Homo sapiens
145 TJP2 9414
Affinity Capture-MS Homo sapiens
146 EPS8L1 54869
Affinity Capture-MS Homo sapiens
147 NAAA  
Affinity Capture-MS Homo sapiens
148 GPR45  
Affinity Capture-MS Homo sapiens
149 SMPD3  
Affinity Capture-MS Homo sapiens
150 LGALS7B 653499
Affinity Capture-MS Homo sapiens
151 ASPH 444
Affinity Capture-MS Homo sapiens
152 ANXA1 301
Affinity Capture-MS Homo sapiens
153 HPSE 10855
Affinity Capture-MS Homo sapiens
154 KLK9  
Affinity Capture-MS Homo sapiens
155 AHNAK2 113146
Affinity Capture-MS Homo sapiens
156 HAX1  
Affinity Capture-MS Homo sapiens
157 TMPRSS5  
Affinity Capture-MS Homo sapiens
158 SDR9C7  
Affinity Capture-MS Homo sapiens
159 ARHGAP1 392
Affinity Capture-MS Homo sapiens
160 SERPINA12  
Affinity Capture-MS Homo sapiens
161 ALOX12B  
Affinity Capture-MS Homo sapiens
162 AKAP1 8165
Proximity Label-MS Homo sapiens
163 LGALSL 29094
Affinity Capture-MS Homo sapiens
164 PKP3 11187
Affinity Capture-MS Homo sapiens
165 DSP 1832
Affinity Capture-MS Homo sapiens
166 CHI3L2 1117
Affinity Capture-MS Homo sapiens
167 GSN 2934
Affinity Capture-MS Homo sapiens
168 MAGEA8  
Affinity Capture-MS Homo sapiens
169 JMJD7-PLA2G4B  
Affinity Capture-MS Homo sapiens
170 PLA2G4E  
Affinity Capture-MS Homo sapiens
171 IL18 3606
Affinity Capture-MS Homo sapiens
172 USE1 55850
Affinity Capture-MS Homo sapiens
173 RNASE7 84659
Affinity Capture-MS Homo sapiens
174 CTDSP1 58190
Affinity Capture-MS Homo sapiens
175 PREP 5550
Affinity Capture-MS Homo sapiens
176 JUP 3728
Affinity Capture-MS Homo sapiens
177 PLEC 5339
Affinity Capture-MS Homo sapiens
178 SDR16C5  
Affinity Capture-MS Homo sapiens
179 CALML5 51806
Affinity Capture-MS Homo sapiens
180 MFSD4  
Affinity Capture-MS Homo sapiens
181 PYCARD 29108
Affinity Capture-MS Homo sapiens
182 IGLL5 100423062
Affinity Capture-MS Homo sapiens
183 CRABP2 1382
Affinity Capture-MS Homo sapiens
184 LGALS3 3958
Affinity Capture-MS Homo sapiens
185 EDEM1  
Affinity Capture-MS Homo sapiens
186 CDSN 1041
Affinity Capture-MS Homo sapiens
187 FGB 2244
Affinity Capture-MS Homo sapiens
188 ITPKC  
Affinity Capture-MS Homo sapiens
189 IGHG2 3501
Affinity Capture-MS Homo sapiens
190 ITPR3 3710
Affinity Capture-MS Homo sapiens
191 KLK7 5650
Affinity Capture-MS Homo sapiens
192 PPP1R13L 10848
Affinity Capture-MS Homo sapiens
193 S100A9 6280
Affinity Capture-MS Homo sapiens
194 PKP1 5317
Affinity Capture-MS Homo sapiens
195 TRIM25 7706
Affinity Capture-MS Homo sapiens
196 TF 7018
Affinity Capture-MS Homo sapiens
197 VPS33A 65082
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
198 RAB5A 5868
Affinity Capture-MS Homo sapiens
199 NDRG2 57447
Affinity Capture-MS Homo sapiens
200 PGM2 55276
Affinity Capture-MS Homo sapiens
201 TGM3 7053
Affinity Capture-MS Homo sapiens
202 KLK10 5655
Affinity Capture-MS Homo sapiens
203 GM2A 2760
Affinity Capture-MS Homo sapiens
204 ME1 4199
Affinity Capture-MS Homo sapiens
205 ZNF185 7739
Affinity Capture-MS Homo sapiens
206 GSDMA 284110
Affinity Capture-MS Homo sapiens
207 PLA2G4D  
Affinity Capture-MS Homo sapiens
208 SERPINB2 5055
Affinity Capture-MS Homo sapiens
209 NCCRP1 342897
Affinity Capture-MS Homo sapiens
210 VAMP5 10791
Affinity Capture-MS Homo sapiens
211 NEU2  
Affinity Capture-MS Homo sapiens
212 ALDH1A3 220
Affinity Capture-MS Homo sapiens
213 VIPR1  
Affinity Capture-MS Homo sapiens
214 ECM1 1893
Affinity Capture-MS Homo sapiens
215 LCN2 3934
Affinity Capture-MS Homo sapiens
216 VPS39 23339
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
217 TRIM29 23650
Affinity Capture-MS Homo sapiens
218 SLC1A1 6505
Affinity Capture-MS Homo sapiens
219 CFH 3075
Affinity Capture-MS Homo sapiens
220 FCHSD1 89848
Affinity Capture-MS Homo sapiens
221 TTC39B 158219
Affinity Capture-MS Homo sapiens
222 SULT2B1 6820
Affinity Capture-MS Homo sapiens
223 CTSH 1512
Affinity Capture-MS Homo sapiens
224 APOA1 335
Affinity Capture-MS Homo sapiens
225 FLG2 388698
Affinity Capture-MS Homo sapiens
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