Gene description for IMPA2
Gene name inositol(myo)-1(or 4)-monophosphatase 2
Gene symbol IMPA2
Other names/aliases -
Species Homo sapiens
 Database cross references - IMPA2
ExoCarta ExoCarta_3613
Vesiclepedia VP_3613
Entrez Gene 3613
HGNC 6051
MIM 605922
UniProt O14732  
 IMPA2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for IMPA2
Molecular Function
    protein binding GO:0005515 IPI
    inositol monophosphate 1-phosphatase activity GO:0008934 IBA
    inositol monophosphate 1-phosphatase activity GO:0008934 IDA
    protein homodimerization activity GO:0042803 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    inositol metabolic process GO:0006020 IBA
    inositol biosynthetic process GO:0006021 IEA
    phosphate-containing compound metabolic process GO:0006796 TAS
    signal transduction GO:0007165 IBA
    response to lithium ion GO:0010226 IDA
    phosphatidylinositol phosphate biosynthetic process GO:0046854 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified IMPA2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 234
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
6
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
7
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IMPA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 PDCD6 10016
Co-fractionation Homo sapiens
3 ERCC3  
Affinity Capture-MS Homo sapiens
4 HSPE1 3336
Co-fractionation Homo sapiens
5 AAR2 25980
Affinity Capture-MS Homo sapiens
6 IMPA2 3613
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 ALDOC 230
Co-fractionation Homo sapiens
8 ADSS 159
Co-fractionation Homo sapiens
9 PGLS 25796
Co-fractionation Homo sapiens
10 C18orf21  
Affinity Capture-MS Homo sapiens
11 PABPC4 8761
Co-fractionation Homo sapiens
12 MSN 4478
Co-fractionation Homo sapiens
13 ARHGDIA 396
Co-fractionation Homo sapiens
14 PINK1  
Affinity Capture-MS Homo sapiens
15 SCPEP1 59342
Co-fractionation Homo sapiens
16 SH2D3A  
Affinity Capture-MS Homo sapiens
17 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
18 NHLRC2 374354
Affinity Capture-MS Homo sapiens
19 PAICS 10606
Co-fractionation Homo sapiens
20 GPX4 2879
Co-fractionation Homo sapiens
21 NPPA  
Affinity Capture-MS Homo sapiens
22 ZC3HC1  
Affinity Capture-MS Homo sapiens
23 ZIC1  
Affinity Capture-MS Homo sapiens
24 RBFOX1 54715
Affinity Capture-MS Homo sapiens
25 DUT 1854
Co-fractionation Homo sapiens
26 PARK7 11315
Co-fractionation Homo sapiens
27 KLRD1  
Affinity Capture-MS Homo sapiens
28 SPACA1 81833
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SLC44A3  
Two-hybrid Homo sapiens
30 HSF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 PTDSS1 9791
Affinity Capture-MS Homo sapiens
32 RPE  
Co-fractionation Homo sapiens
33 GLO1 2739
Co-fractionation Homo sapiens
34 TXN 7295
Co-fractionation Homo sapiens
35 IMPA1 3612
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
36 ARL3 403
Co-fractionation Homo sapiens
37 RDX 5962
Co-fractionation Homo sapiens
38 ZDHHC6  
Affinity Capture-MS Homo sapiens
39 TEFM  
Affinity Capture-MS Homo sapiens
40 SARAF  
Affinity Capture-MS Homo sapiens
41 ITPA 3704
Co-fractionation Homo sapiens
42 TSPAN6 7105
Affinity Capture-MS Homo sapiens
43 A4GNT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 SERPINB8 5271
Co-fractionation Homo sapiens
45 PLIN3 10226
Co-fractionation Homo sapiens
46 ALDOA 226
Co-fractionation Homo sapiens
47 NUDT3 11165
Affinity Capture-MS Homo sapiens
48 STMN1 3925
Co-fractionation Homo sapiens
49 UBA3 9039
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
50 CARHSP1 23589
Co-fractionation Homo sapiens
51 NUDT9 53343
Co-fractionation Homo sapiens
52 APTX  
Affinity Capture-MS Homo sapiens
53 UPK1A 11045
Affinity Capture-MS Homo sapiens
54 FSCN1 6624
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
55 PLD6  
Affinity Capture-MS Homo sapiens
56 CCR1  
Affinity Capture-MS Homo sapiens
57 NDST2  
Affinity Capture-MS Homo sapiens
58 TNFRSF14  
Two-hybrid Homo sapiens
59 STX17 55014
Affinity Capture-MS Homo sapiens
60 CYCS 54205
Co-fractionation Homo sapiens
61 RIPPLY3  
Affinity Capture-MS Homo sapiens
62 SOX2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IMPA2 is involved
PathwayEvidenceSource
Inositol phosphate metabolism TAS Reactome
Metabolism TAS Reactome
Synthesis of IP2, IP, and Ins in the cytosol TAS Reactome





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