Gene description for DUT
Gene name deoxyuridine triphosphatase
Gene symbol DUT
Other names/aliases dUTPase
Species Homo sapiens
 Database cross references - DUT
ExoCarta ExoCarta_1854
Entrez Gene 1854
HGNC 3078
MIM 601266
UniProt P33316  
 DUT identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for DUT
Molecular Function
    protein binding GO:0005515 IPI
    dUTP diphosphatase activity GO:0004170 EXP
    magnesium ion binding GO:0000287 IBA
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
    nucleobase-containing compound metabolic process GO:0006139 TAS
    DNA replication GO:0006260 TAS
    dUMP biosynthetic process GO:0006226 IEA
    pyrimidine nucleoside biosynthetic process GO:0046134 TAS
    dUTP catabolic process GO:0046081 IBA
    pyrimidine nucleobase metabolic process GO:0006206 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 IEA
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified DUT in exosomes
1
Experiment ID 79
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for DUT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FLJ22494  
Two-hybrid Homo sapiens
2 PPARG 5468
Affinity Capture-MS Homo sapiens
3 PPARA  
Affinity Capture-MS Homo sapiens
4 DUT 1854
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PPARD  
Affinity Capture-MS Homo sapiens
6 SPATA2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DUT is involved
No pathways found





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