Gene description for FKBP5
Gene name FK506 binding protein 5
Gene symbol FKBP5
Other names/aliases AIG6
FKBP51
FKBP54
P54
PPIase
Ptg-10
Species Homo sapiens
 Database cross references - FKBP5
ExoCarta ExoCarta_2289
Entrez Gene 2289
HGNC 3721
MIM 602623
UniProt Q13451  
 FKBP5 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for FKBP5
Molecular Function
    FK506 binding GO:0005528 TAS
    protein binding GO:0005515 IPI
    heat shock protein binding GO:0031072 IPI
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IDA
Biological Process
    protein folding GO:0006457 TAS
    protein peptidyl-prolyl isomerization GO:0000413 IEA
    chaperone-mediated protein folding GO:0061077 IDA
Subcellular Localization
    membrane GO:0016020 IDA
    cytoplasm GO:0005737 IBA
    nucleoplasm GO:0005654 IDA
    extracellular exosome GO:0070062 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
 Experiment description of studies that identified FKBP5 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FKBP5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ESR1  
Reconstituted Complex Homo sapiens
2 PGR  
Affinity Capture-Western Homo sapiens
3 MAP3K1 4214
Affinity Capture-MS Homo sapiens
4 HSF1  
Reconstituted Complex Homo sapiens
5 HSP90AA1 3320
Invivo Homo sapiens
Invitro Homo sapiens
6 IKBKE  
Affinity Capture-MS Homo sapiens
7 FES 2242
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which FKBP5 is involved
No pathways found





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