Gene description for PRKAA1
Gene name	protein kinase, AMP-activated, alpha 1 catalytic subunit
Gene symbol	PRKAA1
Other names/aliases	AMPK AMPKa1
Species	Homo sapiens
Database cross references - PRKAA1
ExoCarta	ExoCarta_5562
Entrez Gene	5562
HGNC	9376
MIM	602739
UniProt	Q13131
PRKAA1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for PRKAA1

Molecular Function     protein binding GO:0005515 IPI     chromatin binding GO:0003682 ISS     [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity GO:0047322 IEA     kinase binding GO:0019900 IEA     [acetyl-CoA carboxylase] kinase activity GO:0050405 IEA     histone serine kinase activity GO:0035174 ISS     protein kinase activity GO:0004672 IDA     cAMP-dependent protein kinase activity GO:0004691 NAS     tau-protein kinase activity GO:0050321 IEA     AMP-activated protein kinase activity GO:0004679 IDA     metal ion binding GO:0046872 IEA     protein C-terminus binding GO:0008022 IEA     ATP binding GO:0005524 IEA Biological Process     rhythmic process GO:0048511 IEA     response to hypoxia GO:0001666 NAS     insulin receptor signaling pathway GO:0008286 TAS     cellular response to glucose starvation GO:0042149 ISS     glucose metabolic process GO:0006006 IEA     response to UV GO:0009411 IEA     positive regulation of autophagy GO:0010508 ISS     response to camptothecin GO:1901563 IEA     cellular response to ethanol GO:0071361 IEA     fatty acid oxidation GO:0019395 IEA     regulation of transcription, DNA-templated GO:0006355 IEA     cellular response to hydrogen peroxide GO:0070301 IEA     positive regulation of gene expression GO:0010628 IDA     negative regulation of lipid catabolic process GO:0050995 ISS     positive regulation of glycolytic process GO:0045821 ISS     positive regulation of cholesterol biosynthetic process GO:0045542 NAS     positive regulation of cell proliferation GO:0008284 IEA     autophagy GO:0006914 IEA     signal transduction GO:0007165 TAS     cellular response to nutrient levels GO:0031669 ISS     cellular response to hypoxia GO:0071456 IEA     activation of MAPK activity GO:0000187 NAS     regulation of energy homeostasis GO:2000505 ISS     fatty acid biosynthetic process GO:0006633 IEA     lipid biosynthetic process GO:0008610 ISS     intracellular signal transduction GO:0035556 IBA     cell cycle arrest GO:0007050 TAS     protein heterooligomerization GO:0051291 IEA     response to gamma radiation GO:0010332 ISS     negative regulation of glucose import in response to insulin stimulus GO:2001274 IEA     cholesterol biosynthetic process GO:0006695 IEA     protein phosphorylation GO:0006468 IDA     cold acclimation GO:0009631 IEA     histone-serine phosphorylation GO:0035404 IBA     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     negative regulation of glucosylceramide biosynthetic process GO:0046318 NAS     gene expression GO:0010467 TAS     response to activity GO:0014823 IEA     regulation of vesicle-mediated transport GO:0060627 IEA     negative regulation of TOR signaling GO:0032007 ISS     glucose homeostasis GO:0042593 ISS     negative regulation of apoptotic process GO:0043066 ISS     response to caffeine GO:0031000 IEA     fatty acid homeostasis GO:0055089 ISS     Wnt signaling pathway GO:0016055 IEA     regulation of circadian rhythm GO:0042752 ISS Subcellular Localization     apical plasma membrane GO:0016324 IEA     intracellular GO:0005622 IC     cytoplasm GO:0005737 IDA     cytosol GO:0005829 TAS     nucleoplasm GO:0005654 IDA     nucleus GO:0005634 ISS     AMP-activated protein kinase complex GO:0031588 ISS