Gene description for CPE
Gene name carboxypeptidase E
Gene symbol CPE
Other names/aliases -
Species Homo sapiens
 Database cross references - CPE
ExoCarta ExoCarta_1363
Vesiclepedia VP_1363
Entrez Gene 1363
HGNC 2303
MIM 114855
UniProt P16870  
 CPE identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CPE
Molecular Function
    zinc ion binding GO:0008270 IEA
    neurexin family protein binding GO:0042043 IPI
    cell adhesion molecule binding GO:0050839 IPI
    metallocarboxypeptidase activity GO:0004181 IEA
    carboxypeptidase activity GO:0004180 TAS
Biological Process
    metabolic process GO:0008152 TAS
    Wnt signaling pathway GO:0016055 IDA
    protein localization to membrane GO:0072657 IDA
    cellular protein metabolic process GO:0044267 TAS
    insulin processing GO:0030070 IEA
    cellular protein modification process GO:0006464 NAS
    neuropeptide signaling pathway GO:0007218 NAS
    cardiac left ventricle morphogenesis GO:0003214 IMP
Subcellular Localization
    plasma membrane GO:0005886 TAS
    transport vesicle membrane GO:0030658 IEA
    extracellular exosome GO:0070062 IDA
    Golgi apparatus GO:0005794 IDA
    nucleus GO:0005634 IEA
    secretory granule membrane GO:0030667 TAS
 Experiment description of studies that identified CPE in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CPE
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLDIP2 26073
Two-hybrid Homo sapiens
2 POLA2  
Two-hybrid Homo sapiens
3 GTF3C1  
Two-hybrid Homo sapiens
4 RPA1 6117
Two-hybrid Homo sapiens
5 GCG  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
6 PMCH  
Affinity Capture-MS Homo sapiens
7 UTP14A 10813
Two-hybrid Homo sapiens
8 CHD3 1107
Two-hybrid Homo sapiens
9 MED31  
Two-hybrid Homo sapiens
10 ROBO2 6092
Two-hybrid Homo sapiens
11 RIF1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CPE is involved
PathwayEvidenceSource
Insulin processing TAS Reactome





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