Gene description for ST14
Gene name suppression of tumorigenicity 14 (colon carcinoma)
Gene symbol ST14
Other names/aliases ARCI11
HAI
MT-SP1
MTSP1
PRSS14
SNC19
TADG15
TMPRSS14
Species Homo sapiens
 Database cross references - ST14
ExoCarta ExoCarta_6768
Vesiclepedia VP_6768
Entrez Gene 6768
HGNC 11344
MIM 606797
UniProt Q9Y5Y6  
 ST14 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 22740476    
Colorectal cancer cells 34887515    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Prostate cancer cells 25844599    
 Gene ontology annotations for ST14
Molecular Function
    serine-type endopeptidase activity GO:0004252 IEA
    serine-type peptidase activity GO:0008236 IDA
Biological Process
    neural tube closure GO:0001843 IEA
    proteolysis GO:0006508 IDA
    protein catabolic process GO:0030163 IEA
    keratinocyte differentiation GO:0030216 IBA
    keratinocyte differentiation GO:0030216 IMP
    epithelial cell morphogenesis involved in placental branching GO:0060672 IEA
Subcellular Localization
    extracellular space GO:0005615 IEA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IEA
    basolateral plasma membrane GO:0016323 IEA
 Experiment description of studies that identified ST14 in exosomes
1
Experiment ID 201
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22740476    
Organism Homo sapiens
Experiment description Restoration of full-length APC protein in SW480 colon cancer cells induces exosome-mediated secretion of DKK-4.
Authors "Lim JW, Mathias RA, Kapp EA, Layton MJ, Faux MC, Burgess AW, Ji H, Simpson RJ."
Journal name Electrophoresis
Publication year 2012
Sample Colorectal cancer cells
Sample name SW480
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
3
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for ST14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NOMO1 23420
Affinity Capture-MS Homo sapiens
2 SLIT2 9353
Affinity Capture-MS Homo sapiens
3 NOTCH3 4854
Affinity Capture-MS Homo sapiens
4 KLK15  
Affinity Capture-MS Homo sapiens
5 TOR1A 1861
Affinity Capture-MS Homo sapiens
6 ST6GALNAC4  
Affinity Capture-MS Homo sapiens
7 DPY19L4  
Affinity Capture-MS Homo sapiens
8 FBN2 2201
Affinity Capture-MS Homo sapiens
9 MAN2A1 4124
Affinity Capture-MS Homo sapiens
10 GPC2  
Affinity Capture-MS Homo sapiens
11 GCNT1  
Affinity Capture-MS Homo sapiens
12 TM9SF2 9375
Affinity Capture-MS Homo sapiens
13 JPH1 56704
Affinity Capture-MS Homo sapiens
14 ALG12  
Affinity Capture-MS Homo sapiens
15 CFC1  
Affinity Capture-MS Homo sapiens
16 FKBP7 51661
Affinity Capture-MS Homo sapiens
17 TUSC3 7991
Affinity Capture-MS Homo sapiens
18 ECEL1  
Affinity Capture-MS Homo sapiens
19 AGA 175
Affinity Capture-MS Homo sapiens
20 GLB1L2  
Affinity Capture-MS Homo sapiens
21 TMEM59L  
Affinity Capture-MS Homo sapiens
22 GRAMD1A  
Affinity Capture-MS Homo sapiens
23 LNPEP 4012
Affinity Capture-MS Homo sapiens
24 SLURP1  
Affinity Capture-MS Homo sapiens
25 HS6ST2 90161
Affinity Capture-MS Homo sapiens
26 ITGA6 3655
Affinity Capture-MS Homo sapiens
27 APP 351
Affinity Capture-MS Homo sapiens
28 TOR2A 27433
Affinity Capture-MS Homo sapiens
29 COCH 1690
Affinity Capture-MS Homo sapiens
30 IL6ST 3572
Affinity Capture-MS Homo sapiens
31 NETO2  
Affinity Capture-MS Homo sapiens
32 SERPINE2 5270
Affinity Capture-MS Homo sapiens
33 SEMA6A  
Affinity Capture-MS Homo sapiens
34 GLG1 2734
Affinity Capture-MS Homo sapiens
35 ADAM9 8754
Affinity Capture-MS Homo sapiens
36 VEGFB  
Affinity Capture-MS Homo sapiens
37 CRELD2 79174
Affinity Capture-MS Homo sapiens
38 B4GALT7 11285
Affinity Capture-MS Homo sapiens
39 CLEC2B  
Affinity Capture-MS Homo sapiens
40 GLMP 112770
Affinity Capture-MS Homo sapiens
41 GLT8D2 83468
Affinity Capture-MS Homo sapiens
42 MGAT1 4245
Affinity Capture-MS Homo sapiens
43 OAF 220323
Affinity Capture-MS Homo sapiens
44 ST8SIA5  
Affinity Capture-MS Homo sapiens
45 DDOST 1650
Affinity Capture-MS Homo sapiens
46 PLAC1  
Affinity Capture-MS Homo sapiens
47 SMOC1 64093
Affinity Capture-MS Homo sapiens
48 LIPT2  
Affinity Capture-MS Homo sapiens
49 GPC6 10082
Affinity Capture-MS Homo sapiens
50 MAN1A1 4121
Affinity Capture-MS Homo sapiens
51 EOGT 285203
Affinity Capture-MS Homo sapiens
52 B4GALT1 2683
Affinity Capture-MS Homo sapiens
53 ELSPBP1  
Affinity Capture-MS Homo sapiens
54 BTNL2  
Affinity Capture-MS Homo sapiens
55 TMEM106A  
Affinity Capture-MS Homo sapiens
56 SULF1 23213
Affinity Capture-MS Homo sapiens
57 POGLUT1 56983
Affinity Capture-MS Homo sapiens
58 TMEM87B 84910
Affinity Capture-MS Homo sapiens
59 FEM1A  
Affinity Capture-MS Homo sapiens
60 RNASE4 6038
Affinity Capture-MS Homo sapiens
61 ADAMTS15 170689
Affinity Capture-MS Homo sapiens
62 HLA-G 3135
Affinity Capture-MS Homo sapiens
63 CTSV 1515
Affinity Capture-MS Homo sapiens
64 EMC1 23065
Affinity Capture-MS Homo sapiens
65 LMAN1 3998
Affinity Capture-MS Homo sapiens
66 CHID1 66005
Affinity Capture-MS Homo sapiens
67 TAZ  
Affinity Capture-MS Homo sapiens
68 PAM 5066
Affinity Capture-MS Homo sapiens
69 EIF2AK3  
Affinity Capture-MS Homo sapiens
70 EFNA5  
Affinity Capture-MS Homo sapiens
71 SERPINI1  
Affinity Capture-MS Homo sapiens
72 FAM3C 10447
Affinity Capture-MS Homo sapiens
73 GALNT16 57452
Affinity Capture-MS Homo sapiens
74 ADPGK 83440
Affinity Capture-MS Homo sapiens
75 FBLN1 2192
Affinity Capture-MS Homo sapiens
76 C3orf58 205428
Affinity Capture-MS Homo sapiens
77 NTN1 9423
Affinity Capture-MS Homo sapiens
78 B4GALT2  
Affinity Capture-MS Homo sapiens
79 LINGO1 84894
Affinity Capture-MS Homo sapiens
80 UGT8  
Affinity Capture-MS Homo sapiens
81 VCAN 1462
Affinity Capture-MS Homo sapiens
82 APLP2 334
Affinity Capture-MS Homo sapiens
83 GALNT3 2591
Affinity Capture-MS Homo sapiens
84 PCSK5 5125
Affinity Capture-MS Homo sapiens
85 BACE2 25825
Affinity Capture-MS Homo sapiens
86 BCHE 590
Affinity Capture-MS Homo sapiens
87 WNT5A 7474
Affinity Capture-MS Homo sapiens
88 JAG2  
Affinity Capture-MS Homo sapiens
89 LMF2 91289
Affinity Capture-MS Homo sapiens
90 TMX4 56255
Affinity Capture-MS Homo sapiens
91 FBLN5 10516
Affinity Capture-MS Homo sapiens
92 ADAMTS1 9510
Affinity Capture-MS Homo sapiens
93 TGFBR3 7049
Affinity Capture-MS Homo sapiens
94 PLXNA2 5362
Affinity Capture-MS Homo sapiens
95 UGT3A2  
Affinity Capture-MS Homo sapiens
96 PDGFC 56034
Biochemical Activity Homo sapiens
97 LYPD4  
Affinity Capture-MS Homo sapiens
98 MGAT2 4247
Affinity Capture-MS Homo sapiens
99 FAM69A 388650
Affinity Capture-MS Homo sapiens
100 TXNDC11 51061
Affinity Capture-MS Homo sapiens
101 EPHB4 2050
Affinity Capture-MS Homo sapiens
102 FKBP2 2286
Affinity Capture-MS Homo sapiens
103 ULBP3 79465
Affinity Capture-MS Homo sapiens
104 C1GALT1C1 29071
Affinity Capture-MS Homo sapiens
105 VLDLR 7436
Affinity Capture-MS Homo sapiens
106 PLAT 5327
Affinity Capture-MS Homo sapiens
107 GPC4 2239
Affinity Capture-MS Homo sapiens
108 ZNF664  
Affinity Capture-MS Homo sapiens
109 IGSF8 93185
Affinity Capture-MS Homo sapiens
110 WNT3A 89780
Affinity Capture-MS Homo sapiens
111 TOR3A 64222
Affinity Capture-MS Homo sapiens
112 GALNT6 11226
Affinity Capture-MS Homo sapiens
113 MEX3A  
Affinity Capture-RNA Homo sapiens
114 ATRN 8455
Affinity Capture-MS Homo sapiens
115 LAMB1 3912
Affinity Capture-MS Homo sapiens
116 PRG2  
Affinity Capture-MS Homo sapiens
117 CRIM1 51232
Affinity Capture-MS Homo sapiens
118 SPON1 10418
Affinity Capture-MS Homo sapiens
119 DNAJB9 4189
Affinity Capture-MS Homo sapiens
120 EGFL7 51162
Affinity Capture-MS Homo sapiens
121 NDST1 3340
Affinity Capture-MS Homo sapiens
122 PCOLCE2 26577
Affinity Capture-MS Homo sapiens
123 NRP2 8828
Affinity Capture-MS Homo sapiens
124 ENTPD7  
Affinity Capture-MS Homo sapiens
125 TMEM67 91147
Affinity Capture-MS Homo sapiens
126 TMEM39A  
Affinity Capture-MS Homo sapiens
127 PRKCI 5584
Affinity Capture-MS Homo sapiens
128 TUBA4A 7277
Affinity Capture-MS Homo sapiens
129 POMT1 10585
Affinity Capture-MS Homo sapiens
130 HAPLN3 145864
Affinity Capture-MS Homo sapiens
131 LYZL1  
Affinity Capture-MS Homo sapiens
132 NOMO3 408050
Affinity Capture-MS Homo sapiens
133 SERPINF1 5176
Affinity Capture-MS Homo sapiens
134 LAMA3 3909
Affinity Capture-MS Homo sapiens
135 FBXO2 26232
Affinity Capture-MS Homo sapiens
136 IGSF3 3321
Affinity Capture-MS Homo sapiens
137 MET 4233
Affinity Capture-MS Homo sapiens
138 GXYLT1 283464
Affinity Capture-MS Homo sapiens
139 SPINK1 6690
Affinity Capture-MS Homo sapiens
140 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
141 GALNT2 2590
Affinity Capture-MS Homo sapiens
142 STC2 8614
Affinity Capture-MS Homo sapiens
143 KIAA0319L 79932
Affinity Capture-MS Homo sapiens
144 CD55 1604
Affinity Capture-MS Homo sapiens
145 GALNT7 51809
Affinity Capture-MS Homo sapiens
146 ALG9 79796
Affinity Capture-MS Homo sapiens
147 ADAM10 102
Affinity Capture-MS Homo sapiens
148 ERO1LB 56605
Affinity Capture-MS Homo sapiens
149 C1GALT1 56913
Affinity Capture-MS Homo sapiens
150 ADAM30 11085
Affinity Capture-MS Homo sapiens
151 SEL1L3  
Affinity Capture-MS Homo sapiens
152 FBN1 2200
Affinity Capture-MS Homo sapiens
153 MR1  
Affinity Capture-MS Homo sapiens
154 INHBE 83729
Affinity Capture-MS Homo sapiens
155 ITGA5 3678
Affinity Capture-MS Homo sapiens
156 PVRL2 5819
Affinity Capture-MS Homo sapiens
157 PDIA5 10954
Affinity Capture-MS Homo sapiens
158 TLL2  
Affinity Capture-MS Homo sapiens
159 NOTCH2 4853
Affinity Capture-MS Homo sapiens
160 LSR 51599
Affinity Capture-MS Homo sapiens
161 ASIC4  
Affinity Capture-MS Homo sapiens
162 SPINT1 6692
Affinity Capture-MS Homo sapiens
163 RFNG  
Affinity Capture-MS Homo sapiens
164 EIF5A2 56648
Affinity Capture-MS Homo sapiens
165 SQSTM1 8878
Affinity Capture-MS Homo sapiens
166 TIMP3 7078
Affinity Capture-MS Homo sapiens
167 RGS16 6004
Two-hybrid Homo sapiens
168 SFTPC  
Affinity Capture-MS Homo sapiens
169 OGFOD3 79701
Affinity Capture-MS Homo sapiens
170 PTPRS 5802
Affinity Capture-MS Homo sapiens
171 IGFBP2 3485
Affinity Capture-MS Homo sapiens
172 UGT1A7 54577
Affinity Capture-MS Homo sapiens
173 RPL23 9349
Affinity Capture-MS Homo sapiens
174 GPC3 2719
Affinity Capture-MS Homo sapiens
175 IGF2R 3482
Affinity Capture-MS Homo sapiens
176 LDLR 3949
Affinity Capture-MS Homo sapiens
177 SEMA3C 10512
Affinity Capture-MS Homo sapiens
178 LRP11  
Affinity Capture-MS Homo sapiens
179 P2RX2  
Affinity Capture-MS Homo sapiens
180 UST  
Affinity Capture-MS Homo sapiens
181 ANKRD46 157567
Affinity Capture-MS Homo sapiens
182 SPINT2 10653
Affinity Capture-MS Homo sapiens
183 CRISPLD1 83690
Affinity Capture-MS Homo sapiens
184 GAS6 2621
Affinity Capture-MS Homo sapiens
185 MFGE8 4240
Affinity Capture-MS Homo sapiens
186 HLA-C 3107
Affinity Capture-MS Homo sapiens
187 CPE 1363
Affinity Capture-MS Homo sapiens
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