Gene description for CRELD2
Gene name cysteine-rich with EGF-like domains 2
Gene symbol CRELD2
Other names/aliases -
Species Homo sapiens
 Database cross references - CRELD2
ExoCarta ExoCarta_79174
Vesiclepedia VP_79174
Entrez Gene 79174
HGNC 28150
MIM 607171
UniProt Q6UXH1  
 CRELD2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CRELD2
Molecular Function
    protein disulfide isomerase activity GO:0003756 IEA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Subcellular Localization
    extracellular space GO:0005615 IEA
    endoplasmic reticulum GO:0005783 IEA
    Golgi apparatus GO:0005794 IEA
 Experiment description of studies that identified CRELD2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CRELD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 LYZL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GALNS 2588
Affinity Capture-MS Homo sapiens
4 TOR3A 64222
Affinity Capture-MS Homo sapiens
5 GPIHBP1  
Affinity Capture-MS Homo sapiens
6 C8orf33 65265
Two-hybrid Homo sapiens
7 ELSPBP1  
Affinity Capture-MS Homo sapiens
8 ISLR 3671
Affinity Capture-MS Homo sapiens
9 CUL3 8452
Affinity Capture-MS Homo sapiens
10 MEST 4232
Two-hybrid Homo sapiens
11 IL25  
Affinity Capture-MS Homo sapiens
12 TAZ  
Affinity Capture-MS Homo sapiens
13 TSHR 7253
Affinity Capture-MS Homo sapiens
14 EFNA2  
Affinity Capture-MS Homo sapiens
15 GGH 8836
Affinity Capture-MS Homo sapiens
16 BRINP2  
Affinity Capture-MS Homo sapiens
17 WNT7A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 DUSP15  
Affinity Capture-MS Homo sapiens
19 PDGFRA 5156
Affinity Capture-MS Homo sapiens
20 WNT4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 PRG2  
Affinity Capture-MS Homo sapiens
22 ECEL1  
Affinity Capture-MS Homo sapiens
23 FUT8 2530
Affinity Capture-MS Homo sapiens
24 WNT10A  
Affinity Capture-MS Homo sapiens
25 LYZL1  
Affinity Capture-MS Homo sapiens
26 SLURP1  
Affinity Capture-MS Homo sapiens
27 IGSF5  
Affinity Capture-MS Homo sapiens
28 LTB4R2  
Two-hybrid Homo sapiens
29 F11 2160
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CHCHD4  
Affinity Capture-MS Homo sapiens
31 B3GALT4  
Affinity Capture-MS Homo sapiens
32 SIRPD  
Affinity Capture-MS Homo sapiens
33 BRICD5  
Affinity Capture-MS Homo sapiens
34 ZFP41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 IL12RB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 LCN9  
Affinity Capture-MS Homo sapiens
37 SUV39H1  
Two-hybrid Homo sapiens
38 F7 2155
Affinity Capture-MS Homo sapiens
39 IDS  
Affinity Capture-MS Homo sapiens
40 EDN3  
Affinity Capture-MS Homo sapiens
41 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
42 PATE1  
Affinity Capture-MS Homo sapiens
43 FAM19A2 338811
Affinity Capture-MS Homo sapiens
44 WISP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 ST14 6768
Affinity Capture-MS Homo sapiens
46 CFC1  
Affinity Capture-MS Homo sapiens
47 LYPD4  
Affinity Capture-MS Homo sapiens
48 MAGT1 84061
Affinity Capture-MS Homo sapiens
49 GIP  
Affinity Capture-MS Homo sapiens
50 ZPBP2  
Affinity Capture-MS Homo sapiens
51 CDKN2A 1029
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
52 DNAL4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CRELD2 is involved
No pathways found





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