Gene description for TSHR
Gene name thyroid stimulating hormone receptor
Gene symbol TSHR
Other names/aliases CHNG1
LGR3
hTSHR-I
Species Homo sapiens
 Database cross references - TSHR
ExoCarta ExoCarta_7253
Vesiclepedia VP_7253
Entrez Gene 7253
HGNC 12373
MIM 603372
UniProt P16473  
 TSHR identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TSHR
Molecular Function
    thyroid-stimulating hormone receptor activity GO:0004996 IEA
    G-protein coupled peptide receptor activity GO:0008528 IBA
    protein binding GO:0005515 IPI
Biological Process
    adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 IBA
    cell-cell signaling GO:0007267 TAS
    hormone-mediated signaling pathway GO:0009755 IBA
    G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 TAS
    positive regulation of cell proliferation GO:0008284 TAS
    G-protein coupled receptor signaling pathway GO:0007186 TAS
    thyroid-stimulating hormone signaling pathway GO:0038194 TAS
    activation of adenylate cyclase activity GO:0007190 IBA
Subcellular Localization
    receptor complex GO:0043235 IDA
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified TSHR in exosomes
1
Experiment ID 211
MISEV standards
EM
EV Biophysical techniques
TSG101|Alix|EpCAM|TFRC
EV Enriched markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
EV Biophysical techniques
TSG101|Alix|EpCAM|TFRC
EV Enriched markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TSHR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FN1 2335
Invivo Homo sapiens
2 FLNB 2317
Invitro Homo sapiens
Invivo Homo sapiens
3 GNA13 10672
Affinity Capture-MS Homo sapiens
4 CALR 811
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
5 STAT3 6774
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
6 HSPA5 3309
Invivo Homo sapiens
Invitro Homo sapiens
7 TSHB  
Invivo Homo sapiens
8 GNA12 2768
Affinity Capture-MS Homo sapiens
9 JAK2 3717
Invivo Homo sapiens
10 JAK1 3716
Invivo Homo sapiens
Invitro Homo sapiens
11 CANX 821
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TSHR is involved
PathwayEvidenceSource
G alpha (s) signalling events TAS Reactome
Hormone ligand-binding receptors TAS Reactome





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