Gene description for ITGA7
Gene name integrin, alpha 7
Gene symbol ITGA7
Other names/aliases -
Species Homo sapiens
 Database cross references - ITGA7
ExoCarta ExoCarta_3679
Vesiclepedia VP_3679
Entrez Gene 3679
HGNC 6143
MIM 600536
UniProt Q13683  
 ITGA7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for ITGA7
Molecular Function
    integrin binding GO:0005178 IBA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    cell-matrix adhesion GO:0007160 IBA
    integrin-mediated signaling pathway GO:0007229 IBA
    muscle organ development GO:0007517 TAS
    regulation of cell shape GO:0008360 IEA
    cell adhesion mediated by integrin GO:0033627 IBA
    heterotypic cell-cell adhesion GO:0034113 IMP
    endodermal cell differentiation GO:0035987 IEP
    leukocyte migration GO:0050900 IBA
    cell-cell adhesion GO:0098609 IBA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integrin complex GO:0008305 IBA
    external side of plasma membrane GO:0009897 IBA
    cell surface GO:0009986 IC
 Experiment description of studies that identified ITGA7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ITGA7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 LILRA5  
Affinity Capture-MS Homo sapiens
3 CEACAM8 1088
Affinity Capture-MS Homo sapiens
4 PCDHGA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CFC1  
Affinity Capture-MS Homo sapiens
6 MYOC 4653
Two-hybrid Homo sapiens
7 ECEL1  
Affinity Capture-MS Homo sapiens
8 LGALS1 3956
Affinity Capture-MS Homo sapiens
9 SLC22A9  
Affinity Capture-MS Homo sapiens
10 B3GNT2 10678
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 KLRC1  
Affinity Capture-MS Homo sapiens
12 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
13 BTNL8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 PSG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 IGFL3  
Affinity Capture-MS Homo sapiens
16 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 MAN1A1 4121
Affinity Capture-MS Homo sapiens
18 BTNL2  
Affinity Capture-MS Homo sapiens
19 LGALS8 3964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CLGN 1047
Affinity Capture-MS Homo sapiens
21 DEFB109P1B  
Affinity Capture-MS Homo sapiens
22 TAZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 TSHR 7253
Affinity Capture-MS Homo sapiens
24 TRGV3  
Affinity Capture-MS Homo sapiens
25 HS2ST1 9653
Affinity Capture-MS Homo sapiens
26 ATP1B4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 TMED6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 FHL3 2275
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
29 IDS  
Affinity Capture-MS Homo sapiens
30 SDF2L1 23753
Affinity Capture-MS Homo sapiens
31 CD1E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 C1orf54  
Affinity Capture-MS Homo sapiens
33 B3GAT2  
Affinity Capture-MS Homo sapiens
34 CDHR4  
Affinity Capture-MS Homo sapiens
35 IL17RC 84818
Affinity Capture-MS Homo sapiens
36 CHRNA1  
Affinity Capture-Western Homo sapiens
37 LY86  
Affinity Capture-MS Homo sapiens
38 C7orf34  
Affinity Capture-MS Homo sapiens
39 GPIHBP1  
Affinity Capture-MS Homo sapiens
40 PCDH20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 DEFA1 1667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 PCDHB1  
Affinity Capture-MS Homo sapiens
43 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 C1QA 712
Affinity Capture-MS Homo sapiens
45 GGH 8836
Affinity Capture-MS Homo sapiens
46 PDGFRA 5156
Affinity Capture-MS Homo sapiens
47 PRG2  
Affinity Capture-MS Homo sapiens
48 NCEH1 57552
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 RLN1  
Affinity Capture-MS Homo sapiens
50 CBLN4  
Affinity Capture-MS Homo sapiens
51 ATP1B3 483
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 IL5RA  
Affinity Capture-MS Homo sapiens
53 EMR4P  
Affinity Capture-MS Homo sapiens
54 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
55 NAAA  
Affinity Capture-MS Homo sapiens
56 BST1 683
Affinity Capture-MS Homo sapiens
57 SCGB2A2  
Affinity Capture-MS Homo sapiens
58 PSCA 8000
Affinity Capture-MS Homo sapiens
59 GXYLT1 283464
Affinity Capture-MS Homo sapiens
60 TSPAN11 441631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 NXPH3  
Affinity Capture-MS Homo sapiens
62 CST9L  
Affinity Capture-MS Homo sapiens
63 ISLR 3671
Affinity Capture-MS Homo sapiens
64 TNFSF13B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 FHL2 2274
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
66 EDDM3B  
Affinity Capture-MS Homo sapiens
67 GALNT10 55568
Affinity Capture-MS Homo sapiens
68 ART3  
Affinity Capture-MS Homo sapiens
69 CA10  
Affinity Capture-MS Homo sapiens
70 IGHD  
Affinity Capture-MS Homo sapiens
71 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
72 IGLL5 100423062
Affinity Capture-MS Homo sapiens
73 ASIC4  
Affinity Capture-MS Homo sapiens
74 UQCC1 55245
Affinity Capture-MS Homo sapiens
75 CD1A 909
Affinity Capture-MS Homo sapiens
76 SLAMF1 6504
Affinity Capture-MS Homo sapiens
77 APOM 55937
Affinity Capture-MS Homo sapiens
78 SFTPC  
Affinity Capture-MS Homo sapiens
79 CLEC12B  
Affinity Capture-MS Homo sapiens
80 TMEM25  
Affinity Capture-MS Homo sapiens
81 BRICD5  
Affinity Capture-MS Homo sapiens
82 SUSD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 CD151 977
Affinity Capture-MS Homo sapiens
84 DEFB135  
Affinity Capture-MS Homo sapiens
85 EPHA2 1969
Proximity Label-MS Homo sapiens
86 CST11  
Affinity Capture-MS Homo sapiens
87 KLK3  
Affinity Capture-MS Homo sapiens
88 EDN3  
Affinity Capture-MS Homo sapiens
89 PTCH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 TRAV20  
Affinity Capture-MS Homo sapiens
91 DKKL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 SLC3A2 6520
Affinity Capture-MS Homo sapiens
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