Gene description for APOM
Gene name apolipoprotein M
Gene symbol APOM
Other names/aliases G3a
HSPC336
NG20
apo-M
Species Homo sapiens
 Database cross references - APOM
ExoCarta ExoCarta_55937
Entrez Gene 55937
HGNC 13916
MIM 606907
UniProt O95445  
 APOM identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for APOM
Molecular Function
    antioxidant activity GO:0016209 IDA
    phospholipid binding GO:0005543 IDA
    lipid transporter activity GO:0005319 IDA
Biological Process
    reverse cholesterol transport GO:0043691 ISS
    cholesterol homeostasis GO:0042632 IC
    phototransduction, visible light GO:0007603 TAS
    retinoid metabolic process GO:0001523 TAS
    high-density lipoprotein particle clearance GO:0034384 ISS
    lipoprotein metabolic process GO:0042157 IEA
    cholesterol efflux GO:0033344 IMP
    high-density lipoprotein particle assembly GO:0034380 ISS
    response to glucose GO:0009749 IEA
    high-density lipoprotein particle remodeling GO:0034375 IMP
    negative regulation of plasma lipoprotein particle oxidation GO:0034445 IDA
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    low-density lipoprotein particle GO:0034362 IDA
    extracellular region GO:0005576 TAS
    high-density lipoprotein particle GO:0034364 IDA
    very-low-density lipoprotein particle GO:0034361 IDA
    spherical high-density lipoprotein particle GO:0034366 IDA
    extracellular exosome GO:0070062 IDA
    discoidal high-density lipoprotein particle GO:0034365 IDA
 Experiment description of studies that identified APOM in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for APOM
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C8orf30A  
Two-hybrid Homo sapiens
2 KLF6  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which APOM is involved
PathwayEvidenceSource
Retinoid metabolism and transport TAS Reactome





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