Gene description for BDH1
Gene name 3-hydroxybutyrate dehydrogenase, type 1
Gene symbol BDH1
Other names/aliases BDH
SDR9C1
Species Homo sapiens
 Database cross references - BDH1
ExoCarta ExoCarta_622
Vesiclepedia VP_622
Entrez Gene 622
HGNC 1027
MIM 603063
UniProt Q02338  
 BDH1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for BDH1
Molecular Function
    3-hydroxybutyrate dehydrogenase activity GO:0003858 IBA
    3-hydroxybutyrate dehydrogenase activity GO:0003858 IDA
Biological Process
    steroid metabolic process GO:0008202 IBA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
    intracellular membrane-bounded organelle GO:0043231 IBA
    matrix side of mitochondrial inner membrane GO:0099617 ISS
 Experiment description of studies that identified BDH1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BDH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 MAGEA8  
Affinity Capture-MS Homo sapiens
3 ACSL1 2180
Affinity Capture-MS Homo sapiens
4 ISCA1  
Affinity Capture-MS Homo sapiens
5 HDAC4  
Affinity Capture-MS Homo sapiens
6 IL13RA2 3598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SLC15A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 NAAA  
Affinity Capture-MS Homo sapiens
9 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 SLC18A1  
Affinity Capture-MS Homo sapiens
11 AIFM1 9131
Affinity Capture-MS Homo sapiens
12 MGARP  
Affinity Capture-MS Homo sapiens
13 TNF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CMTM8  
Affinity Capture-MS Homo sapiens
15 HCST  
Affinity Capture-MS Homo sapiens
16 MFSD4  
Affinity Capture-MS Homo sapiens
17 LPAR6  
Affinity Capture-MS Homo sapiens
18 NPTN 27020
Affinity Capture-MS Homo sapiens
19 MEN1 4221
Affinity Capture-MS Homo sapiens
20 ERGIC3 51614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 MAGEA1  
Affinity Capture-MS Homo sapiens
22 LAMP2 3920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 CD79A  
Affinity Capture-MS Homo sapiens
24 AQP3  
Affinity Capture-MS Homo sapiens
25 MARC1  
Affinity Capture-MS Homo sapiens
26 APOM 55937
Affinity Capture-MS Homo sapiens
27 APP 351
Reconstituted Complex Homo sapiens
28 SPACA1 81833
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SLC39A9 55334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CD80 941
Affinity Capture-MS Homo sapiens
31 GPR45  
Affinity Capture-MS Homo sapiens
32 COQ9  
Affinity Capture-MS Homo sapiens
33 THBS3 7059
Affinity Capture-MS Homo sapiens
34 PGM3 5238
Affinity Capture-MS Homo sapiens
35 GLMP 112770
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 LPAR4  
Affinity Capture-MS Homo sapiens
37 P2RY10  
Affinity Capture-MS Homo sapiens
38 VIPR1  
Affinity Capture-MS Homo sapiens
39 TMPRSS5  
Affinity Capture-MS Homo sapiens
40 SLC22A4 6583
Affinity Capture-MS Homo sapiens
41 B3GALT5  
Affinity Capture-MS Homo sapiens
42 CUL4A 8451
Affinity Capture-MS Homo sapiens
43 SOX2  
Affinity Capture-MS Homo sapiens
44 QTRTD1  
Affinity Capture-MS Homo sapiens
45 HIF1A 3091
Affinity Capture-MS Homo sapiens
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