Gene description for MEN1
Gene name	multiple endocrine neoplasia I
Gene symbol	MEN1
Other names/aliases	MEAI SCG2
Species	Homo sapiens
Database cross references - MEN1
ExoCarta	ExoCarta_4221
Vesiclepedia	VP_4221
Entrez Gene	4221
HGNC	7010
MIM	613733
UniProt	O00255
MEN1 identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for MEN1

Molecular Function     Y-form DNA binding GO:0000403 IDA     double-stranded DNA binding GO:0003690 IDA     four-way junction DNA binding GO:0000400 IDA     sequence-specific DNA binding GO:0043565 IEA     chromatin binding GO:0003682 IBA     histone-lysine N-methyltransferase activity GO:0018024 IDA     protein binding, bridging GO:0030674 IDA     protein N-terminus binding GO:0047485 IPI     transcription regulatory region DNA binding GO:0044212 IDA     R-SMAD binding GO:0070412 IPI     protein binding GO:0005515 IPI Biological Process     negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 IMP     cell cycle arrest GO:0007050 IEA     leukocyte homeostasis GO:0001776 IEA     DNA repair GO:0006281 NAS     negative regulation of transcription, DNA-templated GO:0045892 IDA     positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IMP     negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IDA     MAPK cascade GO:0000165 IDA     positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 IEA     transcription, DNA-templated GO:0006351 TAS     maternal process involved in female pregnancy GO:0060135 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 TAS     positive regulation of osteoblast differentiation GO:0045669 IEA     response to gamma radiation GO:0010332 IDA     histone lysine methylation GO:0034968 IDA     negative regulation of telomerase activity GO:0051974 IMP     small GTPase mediated signal transduction GO:0007264 TAS     negative regulation of organ growth GO:0046621 IEA     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     chromatin remodeling GO:0006338 IEA     cellular response to DNA damage stimulus GO:0006974 IDA     negative regulation of cell proliferation GO:0008285 IDA     negative regulation of protein phosphorylation GO:0001933 IDA     osteoblast development GO:0002076 IGI     regulation of activin receptor signaling pathway GO:0032925 IEA     hemopoiesis GO:0030097 IEA     brain development GO:0007420 IEA     gene expression GO:0010467 TAS     positive regulation of protein binding GO:0032092 IDA     positive regulation of cell division GO:0051781 IEA     response to UV GO:0009411 IDA     negative regulation of cell cycle GO:0045786 IDA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA     palate development GO:0060021 IEA     embryonic skeletal system morphogenesis GO:0048704 IEA     positive regulation of histone methylation GO:0031062 IEA     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     negative regulation of osteoblast differentiation GO:0045668 IGI     osteoblast fate commitment GO:0002051 IEA     negative regulation of JNK cascade GO:0046329 IDA Subcellular Localization     protein complex GO:0043234 IDA     chromatin GO:0000785 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     nucleus GO:0005634 IDA     cytosol GO:0005829 TAS     cleavage furrow GO:0032154 IDA     histone methyltransferase complex GO:0035097 IPI     nuclear matrix GO:0016363 IDA