Gene description for MEN1
Gene name multiple endocrine neoplasia I
Gene symbol MEN1
Other names/aliases MEAI
SCG2
Species Homo sapiens
 Database cross references - MEN1
ExoCarta ExoCarta_4221
Vesiclepedia VP_4221
Entrez Gene 4221
HGNC 7010
MIM 613733
UniProt O00255  
 MEN1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for MEN1
Molecular Function
    four-way junction DNA binding GO:0000400 IDA
    Y-form DNA binding GO:0000403 IBA
    Y-form DNA binding GO:0000403 IDA
    transcription cis-regulatory region binding GO:0000976 IBA
    transcription cis-regulatory region binding GO:0000976 IDA
    chromatin binding GO:0003682 IBA
    double-stranded DNA binding GO:0003690 IDA
    protein binding GO:0005515 IPI
    protein-macromolecule adaptor activity GO:0030674 IDA
    phosphoprotein binding GO:0051219 IPI
    R-SMAD binding GO:0070412 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    MAPK cascade GO:0000165 IDA
    negative regulation of protein phosphorylation GO:0001933 IDA
    osteoblast development GO:0002076 IGI
    DNA repair GO:0006281 NAS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    DNA damage response GO:0006974 IDA
    negative regulation of cell population proliferation GO:0008285 IBA
    negative regulation of cell population proliferation GO:0008285 IDA
    response to UV GO:0009411 IDA
    response to gamma radiation GO:0010332 IDA
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IMP
    negative regulation of DNA-binding transcription factor activity GO:0043433 IDA
    T-helper 2 cell differentiation GO:0045064 IDA
    negative regulation of osteoblast differentiation GO:0045668 IGI
    negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 IMP
    negative regulation of cell cycle GO:0045786 IBA
    negative regulation of cell cycle GO:0045786 IDA
    transcription initiation-coupled chromatin remodeling GO:0045815 IMP
    negative regulation of DNA-templated transcription GO:0045892 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    negative regulation of JNK cascade GO:0046329 IDA
Subcellular Localization
    chromosome, telomeric region GO:0000781 ISS
    chromatin GO:0000785 IBA
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum lumen GO:0005788 TAS
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    nuclear matrix GO:0016363 IDA
    transcription repressor complex GO:0017053 IPI
    cleavage furrow GO:0032154 IDA
    protein-containing complex GO:0032991 IDA
    histone methyltransferase complex GO:0035097 IBA
    histone methyltransferase complex GO:0035097 IDA
    MLL1/2 complex GO:0044665 IPI
    MLL1 complex GO:0071339 IPI
 Experiment description of studies that identified MEN1 in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MEN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
2 TRMT1L 81627
Affinity Capture-MS Homo sapiens
3 HDAC2 3066
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
4 JMJD1C 221037
Affinity Capture-MS Homo sapiens
5 EIF3C 8663
Affinity Capture-MS Homo sapiens
6 TOP2B 7155
Affinity Capture-MS Homo sapiens
7 NOP14 8602
Affinity Capture-MS Homo sapiens
8 CRK 1398
Affinity Capture-MS Homo sapiens
9 PISD  
Affinity Capture-MS Homo sapiens
10 UBE3A 7337
Affinity Capture-MS Homo sapiens
11 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
12 INTS1 26173
Affinity Capture-MS Homo sapiens
13 KANSL3  
Affinity Capture-MS Homo sapiens
14 TAF1  
Affinity Capture-Western Homo sapiens
15 APEX1 328
Affinity Capture-RNA Homo sapiens
16 ZNF687  
Affinity Capture-MS Homo sapiens
17 DDX23 9416
Affinity Capture-MS Homo sapiens
18 MLLT11  
Affinity Capture-MS Homo sapiens
19 CRNKL1 51340
Affinity Capture-MS Homo sapiens
20 GPATCH1  
Affinity Capture-MS Homo sapiens
21 RPRM  
Affinity Capture-MS Homo sapiens
22 AFF4 27125
Affinity Capture-MS Homo sapiens
23 PPP2R5D 5528
Affinity Capture-MS Homo sapiens
24 WT1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
25 NUP153 9972
Affinity Capture-MS Homo sapiens
26 DRG1 4733
Affinity Capture-MS Homo sapiens
27 TFIP11  
Affinity Capture-MS Homo sapiens
28 BOD1L1 259282
Affinity Capture-MS Homo sapiens
29 RPF2 84154
Affinity Capture-MS Homo sapiens
30 SNRPD3 6634
Affinity Capture-MS Homo sapiens
31 SMAD5 4090
Affinity Capture-Western Homo sapiens
32 NSFL1C 55968
Affinity Capture-MS Homo sapiens
33 WDR5 11091
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
34 RAD23A 5886
Affinity Capture-MS Homo sapiens
35 UNC45A 55898
Affinity Capture-MS Homo sapiens
36 SRBD1  
Affinity Capture-MS Homo sapiens
37 TCOF1 6949
Affinity Capture-MS Homo sapiens
38 PUS1 80324
Affinity Capture-MS Homo sapiens
39 UBE4B 10277
Affinity Capture-MS Homo sapiens
40 SCYL1 57410
Affinity Capture-MS Homo sapiens
41 BATF  
Affinity Capture-MS Homo sapiens
42 RFC5 5985
Affinity Capture-MS Homo sapiens
43 DERA 51071
Affinity Capture-MS Homo sapiens
44 C17orf85  
Affinity Capture-MS Homo sapiens
45 RBM7  
Affinity Capture-MS Homo sapiens
46 ZHX3  
Affinity Capture-MS Homo sapiens
47 YAP1 10413
Affinity Capture-MS Homo sapiens
48 MYH9 4627
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
49 OGT 8473
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
50 JADE2 23338
Affinity Capture-MS Homo sapiens
51 NCAPD3 23310
Affinity Capture-MS Homo sapiens
52 CCNT1  
Affinity Capture-MS Homo sapiens
53 ZFP36L2 678
Affinity Capture-MS Homo sapiens
54 ANLN 54443
Co-fractionation Homo sapiens
55 EARS2  
Affinity Capture-MS Homo sapiens
56 NOC3L 64318
Affinity Capture-MS Homo sapiens
57 MRTO4 51154
Affinity Capture-MS Homo sapiens
58 MAD1L1  
Affinity Capture-MS Homo sapiens
59 ERBB2IP 55914
Affinity Capture-MS Homo sapiens
60 ANXA1 301
Protein-peptide Homo sapiens
61 PRKAR1A 5573
Co-fractionation Homo sapiens
62 SKP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
63 KANSL2  
Affinity Capture-MS Homo sapiens
64 GRHL2  
Affinity Capture-MS Homo sapiens
65 BAZ2A  
Affinity Capture-MS Homo sapiens
66 FANCA  
Affinity Capture-Luminescence Homo sapiens
67 SPEN 23013
Affinity Capture-MS Homo sapiens
68 RPA3 6119
Proximity Label-MS Homo sapiens
69 ZMYND8 23613
Affinity Capture-MS Homo sapiens
70 DHRS7B 25979
Affinity Capture-MS Homo sapiens
71 SBNO1 55206
Affinity Capture-MS Homo sapiens
72 HSPA4 3308
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
73 ZNF384  
Affinity Capture-MS Homo sapiens
74 ATN1  
Affinity Capture-MS Homo sapiens
75 PARL  
Affinity Capture-MS Homo sapiens
76 UPF2 26019
Affinity Capture-MS Homo sapiens
77 SUPT16H 11198
Affinity Capture-MS Homo sapiens
78 MED14  
Affinity Capture-MS Homo sapiens
79 G3BP1 10146
Affinity Capture-MS Homo sapiens
80 YIF1B 90522
Affinity Capture-MS Homo sapiens
81 STUB1 10273
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
82 DDX46 9879
Affinity Capture-MS Homo sapiens
83 RELA 5970
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
84 PPT1 5538
Affinity Capture-MS Homo sapiens
85 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
86 MBD3 53615
Affinity Capture-MS Homo sapiens
87 INTS9 55756
Affinity Capture-MS Homo sapiens
88 KMT2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 FOXB1  
Affinity Capture-MS Homo sapiens
90 MISP 126353
Affinity Capture-MS Homo sapiens
91 KPNA6 23633
Affinity Capture-MS Homo sapiens
92 Chmp2a 68953
Affinity Capture-MS Mus musculus
93 EBP  
Affinity Capture-MS Homo sapiens
94 MEF2D  
Affinity Capture-Western Homo sapiens
95 CPSF2 53981
Affinity Capture-MS Homo sapiens
96 BOLA2 552900
Affinity Capture-MS Homo sapiens
97 SSBP1 6742
Affinity Capture-MS Homo sapiens
98 NDC1 55706
Affinity Capture-MS Homo sapiens
99 Lck 16818
Affinity Capture-MS Mus musculus
100 POLA1  
Affinity Capture-MS Homo sapiens
101 SNW1 22938
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
102 NFIC 4782
Affinity Capture-MS Homo sapiens
103 NUP85 79902
Affinity Capture-MS Homo sapiens
104 PHF8  
Affinity Capture-MS Homo sapiens
105 RANGAP1 5905
Affinity Capture-MS Homo sapiens
106 IMP4  
Affinity Capture-MS Homo sapiens
107 HIST1H2BC 8347
Affinity Capture-MS Homo sapiens
108 NCOA6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 KPNA3 3839
Affinity Capture-MS Homo sapiens
110 WDR3  
Affinity Capture-MS Homo sapiens
111 FRG1 2483
Affinity Capture-MS Homo sapiens
112 TRRAP 8295
Affinity Capture-MS Homo sapiens
113 NUP188 23511
Affinity Capture-MS Homo sapiens
114 RPA2 6118
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
115 THRAP3 9967
Affinity Capture-MS Homo sapiens
116 GFAP 2670
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
117 JUND 3727
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
118 RSBN1  
Affinity Capture-MS Homo sapiens
119 PSIP1 11168
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
120 XRCC1 7515
Affinity Capture-MS Homo sapiens
121 NCOR1  
Affinity Capture-MS Homo sapiens
122 ZNF148  
Affinity Capture-MS Homo sapiens
123 NOLC1 9221
Affinity Capture-MS Homo sapiens
124 PHLDA2 7262
Affinity Capture-MS Homo sapiens
125 SRRM2 23524
Affinity Capture-MS Homo sapiens
126 KHDRBS1 10657
Affinity Capture-MS Homo sapiens
127 MDC1  
Affinity Capture-MS Homo sapiens
128 Set 56086
Affinity Capture-MS Mus musculus
129 HIST4H4 121504
Affinity Capture-Western Homo sapiens
130 SUN2 25777
Affinity Capture-MS Homo sapiens
131 GRWD1 83743
Affinity Capture-MS Homo sapiens
132 ZNF644  
Affinity Capture-MS Homo sapiens
133 WIZ 58525
Affinity Capture-MS Homo sapiens
134 CUL1 8454
Affinity Capture-MS Homo sapiens
135 SETD1A 9739
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 TP53BP1 7158
Affinity Capture-MS Homo sapiens
137 KANSL1  
Affinity Capture-MS Homo sapiens
138 TTC37 9652
Affinity Capture-MS Homo sapiens
139 PCNP 57092
Affinity Capture-MS Homo sapiens
140 IPO11 51194
Affinity Capture-MS Homo sapiens
141 SYMPK 8189
Affinity Capture-MS Homo sapiens
142 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
143 SAP130  
Affinity Capture-MS Homo sapiens
144 SRP14 6727
Affinity Capture-MS Homo sapiens
145 RBM28 55131
Affinity Capture-MS Homo sapiens
146 PEG10 23089
Affinity Capture-MS Homo sapiens
147 TRA2A 29896
Affinity Capture-MS Homo sapiens
148 EIF2B5 8893
Affinity Capture-MS Homo sapiens
149 NBN 4683
Affinity Capture-MS Homo sapiens
150 ACIN1 22985
Affinity Capture-MS Homo sapiens
151 RNF213 57674
Affinity Capture-MS Homo sapiens
152 C12orf49  
Positive Genetic Homo sapiens
153 UBR5 51366
Affinity Capture-MS Homo sapiens
154 DDX10  
Affinity Capture-MS Homo sapiens
155 SNRPD1 6632
Affinity Capture-MS Homo sapiens
156 NELFE 7936
Affinity Capture-MS Homo sapiens
157 NKRF 55922
Affinity Capture-MS Homo sapiens
158 DCAF7 10238
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
159 BPTF 2186
Affinity Capture-MS Homo sapiens
160 TOX4  
Affinity Capture-MS Homo sapiens
161 PLK1 5347
Affinity Capture-MS Homo sapiens
162 DDX27 55661
Affinity Capture-MS Homo sapiens
163 DRG2 1819
Affinity Capture-MS Homo sapiens
164 ZNF609  
Affinity Capture-MS Homo sapiens
165 RSL1D1 26156
Affinity Capture-MS Homo sapiens
166 ZCCHC8 55596
Affinity Capture-MS Homo sapiens
167 TPX2  
Affinity Capture-MS Homo sapiens
168 MYEF2 50804
Affinity Capture-MS Homo sapiens
169 KHSRP 8570
Affinity Capture-MS Homo sapiens
170 SMCHD1 23347
Affinity Capture-MS Homo sapiens
171 SMARCAD1  
Affinity Capture-MS Homo sapiens
172 DHX36 170506
Affinity Capture-MS Homo sapiens
173 XAB2 56949
Affinity Capture-MS Homo sapiens
174 SEC13 6396
Affinity Capture-MS Homo sapiens
175 UBXN7 26043
Affinity Capture-MS Homo sapiens
176 POLR2E 5434
Affinity Capture-MS Homo sapiens
177 UBE2L6 9246
Affinity Capture-MS Homo sapiens
178 WDR33 55339
Affinity Capture-MS Homo sapiens
179 NUP88 4927
Affinity Capture-MS Homo sapiens
180 SRSF5 6430
Affinity Capture-MS Homo sapiens
181 ZC3HC1  
Affinity Capture-MS Homo sapiens
182 FOSL2  
Affinity Capture-MS Homo sapiens
183 HIST3H3 8290
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
184 ELMSAN1  
Affinity Capture-MS Homo sapiens
185 CD226 10666
Affinity Capture-MS Homo sapiens
186 KDM3B  
Affinity Capture-MS Homo sapiens
187 TAOK2 9344
Affinity Capture-MS Homo sapiens
188 JAK1 3716
Affinity Capture-MS Homo sapiens
189 SET 6418
Affinity Capture-MS Homo sapiens
190 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
191 C19orf70  
Affinity Capture-MS Homo sapiens
192 THOC1 9984
Affinity Capture-MS Homo sapiens
193 SART3 9733
Affinity Capture-MS Homo sapiens
194 DDB1 1642
Affinity Capture-MS Homo sapiens
195 MCM3AP  
Affinity Capture-MS Homo sapiens
196 POLR1D 51082
Affinity Capture-MS Homo sapiens
197 RAE1 8480
Affinity Capture-MS Homo sapiens
198 TCF25 22980
Affinity Capture-MS Homo sapiens
199 WAPAL  
Affinity Capture-MS Homo sapiens
200 SURF6  
Affinity Capture-MS Homo sapiens
201 DIDO1  
Affinity Capture-MS Homo sapiens
202 ILF3 3609
Affinity Capture-MS Homo sapiens
203 TP53 7157
Reconstituted Complex Homo sapiens
204 Atp7a  
Affinity Capture-MS Mus musculus
205 SF3A1 10291
Affinity Capture-MS Homo sapiens
206 FOSL1  
Affinity Capture-MS Homo sapiens
207 VIM 7431
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
208 RIF1  
Affinity Capture-MS Homo sapiens
209 SMAD1 4086
Affinity Capture-Western Homo sapiens
210 ZC3H4 23211
Affinity Capture-MS Homo sapiens
211 CMTR1 23070
Affinity Capture-MS Homo sapiens
212 QSER1  
Affinity Capture-MS Homo sapiens
213 ZNF281  
Affinity Capture-MS Homo sapiens
214 BUB3 9184
Affinity Capture-MS Homo sapiens
215 SETD1B 23067
Affinity Capture-MS Homo sapiens
216 ESR1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
217 STAG1  
Affinity Capture-MS Homo sapiens
218 NCAPD2 9918
Affinity Capture-MS Homo sapiens
219 NOC2L 26155
Affinity Capture-MS Homo sapiens
220 DHX38 9785
Affinity Capture-MS Homo sapiens
221 UTP6  
Affinity Capture-MS Homo sapiens
222 TCF3  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
223 DDX42 11325
Affinity Capture-MS Homo sapiens
224 SMARCAL1  
Affinity Capture-MS Homo sapiens
225 MYC  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
226 AP3D1 8943
Affinity Capture-MS Homo sapiens
227 RAD23B 5887
Affinity Capture-MS Homo sapiens
228 RPP38 10557
Affinity Capture-MS Homo sapiens
229 DARS2 55157
Affinity Capture-MS Homo sapiens
230 CBS 875
Affinity Capture-MS Homo sapiens
231 XPC  
Affinity Capture-MS Homo sapiens
232 SENP3 26168
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
233 GATAD2B 57459
Affinity Capture-MS Homo sapiens
234 PRKCD 5580
Affinity Capture-MS Homo sapiens
235 ATF7  
Affinity Capture-MS Homo sapiens
236 ZNF608  
Affinity Capture-MS Homo sapiens
237 TCF7L2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
238 ORC2  
Affinity Capture-MS Homo sapiens
239 SAMD1  
Affinity Capture-MS Homo sapiens
240 RANBP3 8498
Affinity Capture-MS Homo sapiens
241 MED24 9862
Affinity Capture-MS Homo sapiens