Gene description for JMJD1C
Gene name jumonji domain containing 1C
Gene symbol JMJD1C
Other names/aliases TRIP8
Species Homo sapiens
 Database cross references - JMJD1C
ExoCarta ExoCarta_221037
Entrez Gene 221037
HGNC 12313
MIM 604503
UniProt Q15652  
 JMJD1C identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for JMJD1C
Molecular Function
    dioxygenase activity GO:0051213 IEA
    thyroid hormone receptor binding GO:0046966 TAS
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    chromatin modification GO:0016568 IEA
    blood coagulation GO:0007596 TAS
    oxidation-reduction process GO:0055114 IEA
    regulation of transcription, DNA-templated GO:0006355 TAS
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    intracellular GO:0005622 NAS
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified JMJD1C in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for JMJD1C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Thrb  
Two-hybrid Rattus norvegicus
2 VHL  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which JMJD1C is involved
PathwayEvidenceSource
Factors involved in megakaryocyte development and platelet production TAS Reactome





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