Gene description for MT2A
Gene name metallothionein 2A
Gene symbol MT2A
Other names/aliases MT2
Species Homo sapiens
 Database cross references - MT2A
ExoCarta ExoCarta_4502
Vesiclepedia VP_4502
Entrez Gene 4502
HGNC 7406
MIM 156360
UniProt P02795  
 MT2A identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for MT2A
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 ISS
    drug binding GO:0008144 IDA
Biological Process
    cellular response to drug GO:0035690 IDA
    negative regulation of growth GO:0045926 ISS
    cytokine-mediated signaling pathway GO:0019221 TAS
    interferon-gamma-mediated signaling pathway GO:0060333 TAS
    cellular response to erythropoietin GO:0036018 IEP
    cellular response to zinc ion GO:0071294 IEP
    cellular response to interleukin-3 GO:0036016 IEP
    cellular copper ion homeostasis GO:0006878 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    perinuclear region of cytoplasm GO:0048471 ISS
    cytoplasm GO:0005737 ISS
    nucleus GO:0005634 ISS
 Experiment description of studies that identified MT2A in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for MT2A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKD1 5587
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 ECG2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which MT2A is involved
PathwayEvidenceSource
Interferon gamma signaling TAS Reactome





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