Gene description for DTX2
Gene name deltex 2, E3 ubiquitin ligase
Gene symbol DTX2
Other names/aliases RNF58
Species Homo sapiens
 Database cross references - DTX2
ExoCarta ExoCarta_113878
Vesiclepedia VP_113878
Entrez Gene 113878
HGNC 15973
MIM 613141
UniProt Q86UW9  
 DTX2 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for DTX2
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
Biological Process
    Notch signaling pathway GO:0007219 IBA
    protein ubiquitination GO:0016567 IBA
    protein ubiquitination GO:0016567 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IEA
    nuclear membrane GO:0031965 IDA
 Experiment description of studies that identified DTX2 in exosomes
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for DTX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
Proximity Label-MS Homo sapiens
2 CCAR1 55749
Proximity Label-MS Homo sapiens
3 NUPL2 11097
Proximity Label-MS Homo sapiens
4 FAM208A  
Proximity Label-MS Homo sapiens
5 SLC4A7 9497
Proximity Label-MS Homo sapiens
6 CRTC2 200186
Proximity Label-MS Homo sapiens
7 AFD1  
Proximity Label-MS Homo sapiens
8 NOTCH3 4854
Proximity Label-MS Homo sapiens
9 DGCR14  
Proximity Label-MS Homo sapiens
10 PKP4 8502
Proximity Label-MS Homo sapiens
11 QARS 5859
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 RBPMS 11030
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 JMJD1C 221037
Proximity Label-MS Homo sapiens
14 HNRNPM 4670
Proximity Label-MS Homo sapiens
15 ADCK3  
Two-hybrid Homo sapiens
16 AIPL1  
Proximity Label-MS Homo sapiens
17 PCF11 51585
Proximity Label-MS Homo sapiens
18 LLGL1 3996
Proximity Label-MS Homo sapiens
19 DAG1 1605
Proximity Label-MS Homo sapiens
20 SH3BP4 23677
Proximity Label-MS Homo sapiens
21 NCALD 83988
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 PFKP 5214
Proximity Label-MS Homo sapiens
23 KLC3  
Two-hybrid Homo sapiens
24 ZNF703  
Proximity Label-MS Homo sapiens
25 NUPL1 9818
Proximity Label-MS Homo sapiens
26 PLEKHF2 79666
Two-hybrid Homo sapiens
27 STIM2 57620
Proximity Label-MS Homo sapiens
28 ADD3 120
Proximity Label-MS Homo sapiens
29 SHB 6461
Proximity Label-MS Homo sapiens
30 FAM168A  
Two-hybrid Homo sapiens
31 FUBP3 8939
Proximity Label-MS Homo sapiens
32 RHOXF2  
Two-hybrid Homo sapiens
33 N4BP3  
Proximity Label-MS Homo sapiens
34 TRIM54  
Two-hybrid Homo sapiens
35 BCL9  
Proximity Label-MS Homo sapiens
36 FIP1L1 81608
Proximity Label-MS Homo sapiens
37 EIF4ENIF1 56478
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
38 ETV3  
Proximity Label-MS Homo sapiens
39 MARK2 2011
Proximity Label-MS Homo sapiens
40 C15orf39  
Proximity Label-MS Homo sapiens
41 RBM6 10180
Proximity Label-MS Homo sapiens
42 TNRC6A 27327
Proximity Label-MS Homo sapiens
43 ZNF148  
Proximity Label-MS Homo sapiens
44 GSE1 23199
Proximity Label-MS Homo sapiens
45 USP6NL 9712
Proximity Label-MS Homo sapiens
46 MCM2 4171
Affinity Capture-MS Homo sapiens
47 ERBB2 2064
Proximity Label-MS Homo sapiens
48 SENP1  
Proximity Label-MS Homo sapiens
49 NUP153 9972
Proximity Label-MS Homo sapiens
50 YES1 7525
Proximity Label-MS Homo sapiens
51 TOR1AIP1 26092
Proximity Label-MS Homo sapiens
52 NCOA5  
Proximity Label-MS Homo sapiens
53 CPSF7 79869
Proximity Label-MS Homo sapiens
54 MDC1  
Two-hybrid Homo sapiens
55 KHDRBS1 10657
Proximity Label-MS Homo sapiens
56 HDC  
Two-hybrid Homo sapiens
57 EWSR1 2130
Proximity Label-MS Homo sapiens
58 NCOA3  
Proximity Label-MS Homo sapiens
59 STXBP5 134957
Proximity Label-MS Homo sapiens
60 BCOR  
Proximity Label-MS Homo sapiens
61 SFN 2810
Affinity Capture-MS Homo sapiens
62 INADL 10207
Proximity Label-MS Homo sapiens
63 VSNL1 7447
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 ARNT2  
Two-hybrid Homo sapiens
65 UBQLN4 56893
Two-hybrid Homo sapiens
66 KPNA1 3836
Proximity Label-MS Homo sapiens
67 HPCAL4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
68 STX12 23673
Two-hybrid Homo sapiens
69 RBM14 10432
Proximity Label-MS Homo sapiens
70 LAMTOR1 55004
Proximity Label-MS Homo sapiens
71 ARHGEF11 9826
Proximity Label-MS Homo sapiens
72 NUP155 9631
Proximity Label-MS Homo sapiens
73 TFAP2A  
Proximity Label-MS Homo sapiens
74 PFN1 5216
Proximity Label-MS Homo sapiens
75 MECOM 2122
Proximity Label-MS Homo sapiens
76 SPG21 51324
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
77 TFAP2D  
Proximity Label-MS Homo sapiens
78 MCM3AP  
Proximity Label-MS Homo sapiens
79 HNRNPA0 10949
Proximity Label-MS Homo sapiens
80 RBM12B  
Proximity Label-MS Homo sapiens
81 PLSCR1 5359
Two-hybrid Homo sapiens
82 EMD 2010
Proximity Label-MS Homo sapiens
83 RBM47 54502
Proximity Label-MS Homo sapiens
84 PITX3  
Proximity Label-MS Homo sapiens
85 UBE2D4  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
86 CTBP1 1487
Proximity Label-MS Homo sapiens
87 NCOR2  
Proximity Label-MS Homo sapiens
88 RBM4 5936
Proximity Label-MS Homo sapiens
89 NUP107 57122
Proximity Label-MS Homo sapiens
90 NFIX 4784
Proximity Label-MS Homo sapiens
91 GOLGA2 2801
Two-hybrid Homo sapiens
92 YAP1 10413
Proximity Label-MS Homo sapiens
93 ACACA 31
Proximity Label-MS Homo sapiens
94 ERBB2IP 55914
Proximity Label-MS Homo sapiens
95 NFIA 4774
Proximity Label-MS Homo sapiens
96 NUMB 8650
Proximity Label-MS Homo sapiens
97 DDX5 1655
Proximity Label-MS Homo sapiens
98 PIAS2  
Proximity Label-MS Homo sapiens
99 NFIB  
Proximity Label-MS Homo sapiens
100 DTX2 113878
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
101 NCS1 23413
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
102 RPL27A 6157
Proximity Label-MS Homo sapiens
103 UBE2D3 7323
Two-hybrid Homo sapiens
104 ATP2B4 493
Proximity Label-MS Homo sapiens
105 PKP3 11187
Proximity Label-MS Homo sapiens
106 RAD54L2  
Proximity Label-MS Homo sapiens
107 MCCC1 56922
Proximity Label-MS Homo sapiens
108 AHCTF1 25909
Proximity Label-MS Homo sapiens
109 HNRNPA3 220988
Proximity Label-MS Homo sapiens
110 ZNF609  
Proximity Label-MS Homo sapiens
111 GPRC5A 9052
Proximity Label-MS Homo sapiens
112 RBM10  
Proximity Label-MS Homo sapiens
113 RAVER2  
Proximity Label-MS Homo sapiens
114 TRIP13 9319
Two-hybrid Homo sapiens
115 HNRNPD 3184
Proximity Label-MS Homo sapiens
116 SPAG8  
Two-hybrid Homo sapiens
117 SFPQ 6421
Proximity Label-MS Homo sapiens
118 ZBTB2 57621
Proximity Label-MS Homo sapiens
119 ARHGAP32  
Proximity Label-MS Homo sapiens
120 KHSRP 8570
Proximity Label-MS Homo sapiens
121 VAPB 9217
Proximity Label-MS Homo sapiens
122 RFX7  
Proximity Label-MS Homo sapiens
123 CHERP 10523
Proximity Label-MS Homo sapiens
124 SHROOM3 57619
Proximity Label-MS Homo sapiens
125 R3HDM1  
Proximity Label-MS Homo sapiens
126 DCBLD1  
Proximity Label-MS Homo sapiens
127 HPCAL1 3241
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
128 CCDC120  
Proximity Label-MS Homo sapiens
129 BCL9L  
Proximity Label-MS Homo sapiens
130 SLC30A6 55676
Proximity Label-MS Homo sapiens
131 WDR33 55339
Proximity Label-MS Homo sapiens
132 RPRD2  
Proximity Label-MS Homo sapiens
133 SF1 7536
Proximity Label-MS Homo sapiens
134 YLPM1 56252
Proximity Label-MS Homo sapiens
135 EGFR 1956
Proximity Label-MS Homo sapiens
136 DLX6  
Proximity Label-MS Homo sapiens
137 PLEKHA7 144100
Proximity Label-MS Homo sapiens
138 RBM33  
Proximity Label-MS Homo sapiens
139 RBBP4 5928
Proximity Label-MS Homo sapiens
140 SPG20 23111
Proximity Label-MS Homo sapiens
141 AKAP8  
Proximity Label-MS Homo sapiens
142 SLITRK5  
Proximity Label-MS Homo sapiens
143 KIRREL 55243
Proximity Label-MS Homo sapiens
144 L3MBTL3  
Proximity Label-MS Homo sapiens
145 VGLL3  
Proximity Label-MS Homo sapiens
146 ARHGAP29 9411
Proximity Label-MS Homo sapiens
147 CRTC3  
Proximity Label-MS Homo sapiens
148 ZNF641  
Two-hybrid Homo sapiens
149 COX2 4513
Proximity Label-MS Homo sapiens
150 ALKBH4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
151 EPN3 55040
Proximity Label-MS Homo sapiens
152 RFX6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
153 USP7 7874
Proximity Label-MS Homo sapiens
154 MPZL1 9019
Proximity Label-MS Homo sapiens
155 GLYCTK  
Two-hybrid Homo sapiens
156 PIAS1 8554
Proximity Label-MS Homo sapiens
157 C1orf94  
Two-hybrid Homo sapiens
158 RAI1 10743
Proximity Label-MS Homo sapiens
159 ESRP2 80004
Proximity Label-MS Homo sapiens
160 MATR3 9782
Proximity Label-MS Homo sapiens
161 CROCC 9696
Proximity Label-MS Homo sapiens
162 KIAA0319L 79932
Proximity Label-MS Homo sapiens
163 TMEM209 84928
Proximity Label-MS Homo sapiens
164 LEMD3  
Proximity Label-MS Homo sapiens
165 LMNA 4000
Proximity Label-MS Homo sapiens
166 HPCA 3208
Affinity Capture-MS Homo sapiens
167 MED15  
Proximity Label-MS Homo sapiens
168 FHL2 2274
Two-hybrid Homo sapiens
169 SUMO1 7341
Two-hybrid Homo sapiens
170 UBE2D1 7321
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
171 LBR 3930
Proximity Label-MS Homo sapiens
172 TRIP6 7205
Two-hybrid Homo sapiens
173 NUDT21 11051
Proximity Label-MS Homo sapiens
174 ABHD16A 7920
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
175 ZDHHC5 25921
Proximity Label-MS Homo sapiens
176 RBM27  
Proximity Label-MS Homo sapiens
177 PVRL2 5819
Proximity Label-MS Homo sapiens
178 NUP160 23279
Proximity Label-MS Homo sapiens
179 DAB2 1601
Proximity Label-MS Homo sapiens
180 NUP133 55746
Proximity Label-MS Homo sapiens
181 JUP 3728
Proximity Label-MS Homo sapiens
182 CPSF6 11052
Proximity Label-MS Homo sapiens
183 USP34 9736
Proximity Label-MS Homo sapiens
184 NOTCH2 4853
Proximity Label-MS Homo sapiens
185 SEC16A 9919
Proximity Label-MS Homo sapiens
186 LSR 51599
Proximity Label-MS Homo sapiens
187 SEC23B 10483
Two-hybrid Homo sapiens
188 FLYWCH2  
Proximity Label-MS Homo sapiens
189 SCAF8 22828
Proximity Label-MS Homo sapiens
190 RBMX 27316
Proximity Label-MS Homo sapiens
191 FAM111B 374393
Proximity Label-MS Homo sapiens
192 LATS2 26524
Proximity Label-MS Homo sapiens
193 ELAVL1 1994
Proximity Label-MS Homo sapiens
194 SLC6A9 6536
Proximity Label-MS Homo sapiens
195 NUP35 129401
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
196 DDX58 23586
Affinity Capture-RNA Homo sapiens
197 NUP98 4928
Proximity Label-MS Homo sapiens
198 PRR12 57479
Proximity Label-MS Homo sapiens
199 SUGP2  
Proximity Label-MS Homo sapiens
200 ROR2 4920
Proximity Label-MS Homo sapiens
201 RAVER1 125950
Proximity Label-MS Homo sapiens
202 NUP50 10762
Proximity Label-MS Homo sapiens
203 MBNL1 4154
Proximity Label-MS Homo sapiens
204 LDB1  
Proximity Label-MS Homo sapiens
205 KRTAP26-1  
Two-hybrid Homo sapiens
206 NDC1 55706
Proximity Label-MS Homo sapiens
207 NCOR1  
Proximity Label-MS Homo sapiens
208 WWTR1 25937
Proximity Label-MS Homo sapiens
209 TCF20  
Proximity Label-MS Homo sapiens
210 SEC22A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
211 TCF3  
Proximity Label-MS Homo sapiens
212 HNRNPF 3185
Proximity Label-MS Homo sapiens
213 ACACB 32
Proximity Label-MS Homo sapiens
214 RIMBP3 85376
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
215 CEBPB  
Proximity Label-MS Homo sapiens
216 CEP85  
Proximity Label-MS Homo sapiens
217 NFIC 4782
Proximity Label-MS Homo sapiens
218 NUP85 79902
Proximity Label-MS Homo sapiens
219 POM121C  
Proximity Label-MS Homo sapiens
220 GPS2  
Proximity Label-MS Homo sapiens
221 NOTCH1 4851
Proximity Label-MS Homo sapiens
222 DSG2 1829
Proximity Label-MS Homo sapiens
223 HLA-C 3107
Proximity Label-MS Homo sapiens
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