Gene description for STXBP5
Gene name syntaxin binding protein 5 (tomosyn)
Gene symbol STXBP5
Other names/aliases LGL3
LLGL3
Nbla04300
Species Homo sapiens
 Database cross references - STXBP5
ExoCarta ExoCarta_134957
Entrez Gene 134957
HGNC 19665
MIM 604586
UniProt Q5T5C0  
 STXBP5 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for STXBP5
Molecular Function
    syntaxin-1 binding GO:0017075 ISS
Biological Process
    regulation of gene expression GO:0010468 IMP
    regulation of exocytosis GO:0017157 TAS
    exocytosis GO:0006887 IEA
    protein transport GO:0015031 IEA
    regulation of blood coagulation GO:0030193 IMP
    positive regulation of exocytosis GO:0045921 ISS
Subcellular Localization
    cytoplasmic vesicle membrane GO:0030659 IEA
    cell junction GO:0030054 IEA
    synaptic vesicle GO:0008021 IEA
    cytoplasm GO:0005737 IDA
    acetylcholine-gated channel complex GO:0005892 ISS
 Experiment description of studies that identified STXBP5 in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for STXBP5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STX1A 6804
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
2 STX4 6810
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
3 SNAP23 8773
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which STXBP5 is involved
No pathways found





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