Gene description for ARRB1
Gene name	arrestin, beta 1
Gene symbol	ARRB1
Other names/aliases	ARB1 ARR1
Species	Homo sapiens
Database cross references - ARRB1
ExoCarta	ExoCarta_408
Entrez Gene	408
HGNC	711
MIM	107940
UniProt	P49407
ARRB1 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for ARRB1

Molecular Function     insulin-like growth factor receptor binding GO:0005159 IPI     angiotensin receptor binding GO:0031701 IPI     enzyme inhibitor activity GO:0004857 TAS     cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 IEA     transcription factor binding GO:0008134 IPI     GTPase activator activity GO:0005096 IMP     histone acetyltransferase activity GO:0004402 IDA     protein binding GO:0005515 IPI     mitogen-activated protein kinase kinase binding GO:0031434 IEA     ubiquitin protein ligase binding GO:0031625 IPI     transcription regulatory region DNA binding GO:0044212 IMP Biological Process     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     positive regulation of GTPase activity GO:0043547 IMP     protein ubiquitination GO:0016567 IMP     Notch signaling pathway GO:0007219 TAS     negative regulation of protein ubiquitination GO:0031397 IDA     membrane organization GO:0061024 TAS     negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA     platelet activation GO:0030168 TAS     negative regulation of interleukin-6 production GO:0032715 IDA     G-protein coupled receptor internalization GO:0002031 IMP     positive regulation of protein binding GO:0032092 IEA     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IEA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IMP     positive regulation of receptor internalization GO:0002092 IMP     protein transport GO:0015031 IEA     positive regulation of histone acetylation GO:0035066 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA     positive regulation of Rho protein signal transduction GO:0035025 IMP     positive regulation of protein phosphorylation GO:0001934 IMP     phototransduction GO:0007602 IEA     positive regulation of histone H4 acetylation GO:0090240 IMP     negative regulation of interleukin-8 production GO:0032717 IDA     stress fiber assembly GO:0043149 IMP     transcription from RNA polymerase II promoter GO:0006366 IMP     positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA     positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IEA     post-Golgi vesicle-mediated transport GO:0006892 TAS     blood coagulation GO:0007596 TAS Subcellular Localization     coated pit GO:0005905 IEA     cytosol GO:0005829 TAS     cytoplasmic vesicle membrane GO:0030659 TAS     cytoplasm GO:0005737 IDA     Golgi membrane GO:0000139 TAS     pseudopodium GO:0031143 IEA     cytoplasmic vesicle GO:0031410 IDA     lysosomal membrane GO:0005765 TAS     nucleoplasm GO:0005654 IDA     plasma membrane GO:0005886 TAS     nucleus GO:0005634 IDA     chromatin GO:0000785 IDA     heterotrimeric G-protein complex GO:0005834 TAS