Gene description for DVL1
Gene name dishevelled segment polarity protein 1
Gene symbol DVL1
Other names/aliases DRS2
Species Homo sapiens
 Database cross references - DVL1
ExoCarta ExoCarta_1855
Entrez Gene 1855
HGNC 3084
MIM 601365
UniProt O14640  
 DVL1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DVL1
Molecular Function
    frizzled binding GO:0005109 IPI
    molecular_function GO:0003674 ND
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    protein kinase binding GO:0019901 IPI
    enzyme binding GO:0019899 IPI
    Rac GTPase binding GO:0048365 IEA
Biological Process
    skeletal muscle acetylcholine-gated channel clustering GO:0071340 IEA
    protein localization to nucleus GO:0034504 IMP
    neurotransmitter secretion GO:0007269 ISS
    negative regulation of canonical Wnt signaling pathway GO:0090090 TAS
    axon extension GO:0048675 IEA
    canonical Wnt signaling pathway GO:0060070 IDA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IMP
    convergent extension involved in neural plate elongation GO:0022007 IEA
    collateral sprouting GO:0048668 IEA
    neuromuscular junction development GO:0007528 ISS
    Wnt signaling pathway, planar cell polarity pathway GO:0060071 IDA
    positive regulation of Wnt signaling pathway GO:0030177 IDA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    neural tube development GO:0021915 IEP
    prepulse inhibition GO:0060134 IEA
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of protein binding GO:0032091 IDA
    positive regulation of canonical Wnt signaling pathway GO:0090263 TAS
    synapse organization GO:0050808 ISS
    axon guidance GO:0007411 IEA
    social behavior GO:0035176 IEA
    receptor clustering GO:0043113 ISS
    protein localization to microtubule GO:0035372 IEA
    heart development GO:0007507 NAS
    cytoplasmic microtubule organization GO:0031122 IEA
    dendrite morphogenesis GO:0048813 ISS
    regulation of neurotransmitter levels GO:0001505 ISS
    negative regulation of protein kinase activity GO:0006469 IDA
    cochlea morphogenesis GO:0090103 IEA
    planar cell polarity pathway involved in neural tube closure GO:0090179 IBA
    transcription from RNA polymerase II promoter GO:0006366 IDA
    positive regulation of neuron projection development GO:0010976 IEA
    intracellular signal transduction GO:0035556 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    neuronal cell body GO:0043025 IEA
    cytosol GO:0005829 TAS
    dendrite GO:0030425 IEA
    axon GO:0030424 IEA
    microtubule GO:0005874 IEA
    clathrin-coated vesicle GO:0030136 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 ISS
    cytoplasmic vesicle GO:0031410 IDA
    lateral plasma membrane GO:0016328 IDA
    synapse GO:0045202 ISS
    growth cone GO:0030426 IEA
 Experiment description of studies that identified DVL1 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DVL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AXIN1  
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 SMAD2 4087
Reconstituted Complex Homo sapiens
3 CTNNB1 1499
Affinity Capture-Western Homo sapiens
4 DVL1 1855
Invivo Homo sapiens
Invivo Homo sapiens
5 CSNK1D 1453
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
6 SMAD1  
Reconstituted Complex Homo sapiens
7 DAB2 1601
Reconstituted Complex Homo sapiens
8 EPS8 2059
Invitro Homo sapiens
Two-hybrid Homo sapiens
9 CSNK2A1 1457
Affinity Capture-Western Homo sapiens
10 HECW1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
11 ARRB1 408
Affinity Capture-Western Homo sapiens
12 DVL3  
Invivo Homo sapiens
13 CSNK1E  
Invivo Homo sapiens
Invitro Homo sapiens
14 SMAD7  
Reconstituted Complex Homo sapiens
15 USP13  
Two-hybrid Homo sapiens
16 SMAD3  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
17 DAAM1 23002
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
18 FRAT1 10023
Affinity Capture-Western Homo sapiens
19 SMAD4  
Reconstituted Complex Homo sapiens
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