Gene description for DAB2
Gene name	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Gene symbol	DAB2
Other names/aliases	DOC-2 DOC2
Species	Homo sapiens
Database cross references - DAB2
ExoCarta	ExoCarta_1601
Entrez Gene	1601
HGNC	2662
MIM	601236
UniProt	P98082
DAB2 identified in exosomes derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for DAB2

Molecular Function     protein C-terminus binding GO:0008022 IPI     cargo receptor activity GO:0038024 IMP     protein binding GO:0005515 IPI     integrin binding GO:0005178 IEA     clathrin adaptor activity GO:0035615 IMP     AP-2 adaptor complex binding GO:0035612 IEA     SMAD binding GO:0046332 IDA     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IEA Biological Process     Wnt signaling pathway GO:0016055 IEA     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IMP     integrin-mediated signaling pathway GO:0007229 IMP     negative regulation of protein localization to plasma membrane GO:1903077 IMP     negative regulation of apoptotic process GO:0043066 IDA     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IEA     positive regulation of cell migration GO:0030335 IMP     pinocytosis GO:0006907 IEA     negative regulation of canonical Wnt signaling pathway GO:0090090 IMP     clathrin coat assembly GO:0048268 IEA     positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 IMP     cell morphogenesis involved in differentiation GO:0000904 IEA     positive regulation of early endosome to late endosome transport GO:2000643 IMP     positive regulation of SMAD protein import into nucleus GO:0060391 IDA     positive regulation of transcription, DNA-templated GO:0045893 IMP     apoptotic process GO:0006915 IEA     positive regulation of epithelial to mesenchymal transition GO:0010718 IDA     negative regulation of transcription, DNA-templated GO:0045892 IMP     positive regulation of clathrin-mediated endocytosis GO:2000370 IMP     cellular response to transforming growth factor beta stimulus GO:0071560 IEA     positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968 IEA     negative regulation of androgen receptor signaling pathway GO:0060766 IMP     excretion GO:0007588 IEA     positive regulation of integrin-mediated signaling pathway GO:2001046 IEA     cell proliferation GO:0008283 TAS     receptor-mediated endocytosis GO:0006898 IEA     negative regulation of protein binding GO:0032091 IMP     positive regulation of endocytosis GO:0045807 IMP     activation of JUN kinase activity GO:0007257 IEA     positive regulation of receptor recycling GO:0001921 IEA     protein transport GO:0015031 IEA     in utero embryonic development GO:0001701 IEA     leading edge cell differentiation GO:0035026 IMP     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IEA     positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IDA     positive regulation of protein phosphorylation GO:0001934 IMP     myeloid cell differentiation GO:0030099 IEA     membrane organization GO:0061024 TAS     positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IDA     endoderm development GO:0007492 IEA Subcellular Localization     focal adhesion GO:0005925 IDA     apical plasma membrane GO:0016324 IEA     intracellular membrane-bounded organelle GO:0043231 IDA     transforming growth factor beta receptor homodimeric complex GO:0070022 IDA     extracellular exosome GO:0070062 IDA     lysosomal membrane GO:0005765 TAS     nucleolus GO:0005730 IDA     coated pit GO:0005905 IDA     clathrin-coated vesicle GO:0030136 IDA     plasma membrane GO:0005886 TAS     clathrin coat of coated pit GO:0030132 IEA     clathrin-coated vesicle membrane GO:0030665 IEA