Gene description for CFTR
Gene name	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Gene symbol	CFTR
Other names/aliases	ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1
Species	Homo sapiens
Database cross references - CFTR
ExoCarta	ExoCarta_1080
Vesiclepedia	VP_1080
Entrez Gene	1080
HGNC	1884
MIM	602421
UniProt	P13569
CFTR identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for CFTR

Molecular Function     DNA clamp loader activity GO:0003689 IEA     chloride channel activity GO:0005254 IDA     chloride channel activity GO:0005254 IMP     intracellularly ATP-gated chloride channel activity GO:0005260 IMP     intracellularly ATP-gated chloride channel activity GO:0005260 NAS     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     bicarbonate transmembrane transporter activity GO:0015106 IDA     bicarbonate transmembrane transporter activity GO:0015106 ISS     chloride transmembrane transporter activity GO:0015108 ISS     chloride transmembrane transporter activity GO:0015108 TAS     isomerase activity GO:0016853 IEA     ATP hydrolysis activity GO:0016887 IDA     chloride channel regulator activity GO:0017081 TAS     chloride channel inhibitor activity GO:0019869 IDA     enzyme binding GO:0019899 IPI     PDZ domain binding GO:0030165 IDA     ATPase-coupled transmembrane transporter activity GO:0042626 IBA     ATPase-coupled inorganic anion transmembrane transporter activity GO:0043225 TAS     protein-folding chaperone binding GO:0051087 IPI     cohesin loader activity GO:0061775 IEA     14-3-3 protein binding GO:0071889 EXP     14-3-3 protein binding GO:0071889 IMP     14-3-3 protein binding GO:0071889 IPI     Sec61 translocon complex binding GO:0106138 IDA     ABC-type transporter activity GO:0140359 IEA     chromatin extrusion motor activity GO:0140584 IEA     ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA     ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA Biological Process     chromatin remodeling GO:0006338 IEA     cholesterol biosynthetic process GO:0006695 IEA     vesicle docking involved in exocytosis GO:0006904 IEA     bicarbonate transport GO:0015701 IBA     bicarbonate transport GO:0015701 IDA     cholesterol transport GO:0030301 IEA     response to endoplasmic reticulum stress GO:0034976 IDA     transepithelial water transport GO:0035377 IMP     positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IGI     positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IMP     positive regulation of exocytosis GO:0045921 IMP     sperm capacitation GO:0048240 ISS     multicellular organismal-level water homeostasis GO:0050891 IMP     intracellular pH elevation GO:0051454 ISS     establishment of localization in cell GO:0051649 IEA     transmembrane transport GO:0055085 TAS     membrane hyperpolarization GO:0060081 ISS     positive regulation of enamel mineralization GO:0070175 ISS     cellular response to cAMP GO:0071320 ISS     amelogenesis GO:0097186 ISS     chromatin looping GO:0140588 IEA     positive regulation of cyclic nucleotide-gated ion channel activity GO:1902161 IMP     chloride transmembrane transport GO:1902476 IBA     chloride transmembrane transport GO:1902476 IDA     chloride transmembrane transport GO:1902476 IMP     chloride transmembrane transport GO:1902476 ISS     positive regulation of voltage-gated chloride channel activity GO:1902943 IDA     cellular response to forskolin GO:1904322 IDA Subcellular Localization     nucleus GO:0005634 ISS     cytoplasm GO:0005737 IDA     lysosomal membrane GO:0005765 TAS     early endosome GO:0005769 IDA     endoplasmic reticulum membrane GO:0005789 IDA     endoplasmic reticulum membrane GO:0005789 TAS     cytosol GO:0005829 IBA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IMP     plasma membrane GO:0005886 TAS     cell surface GO:0009986 IDA     endosome membrane GO:0010008 TAS     membrane GO:0016020 IDA     apical plasma membrane GO:0016324 IBA     apical plasma membrane GO:0016324 IDA     apical plasma membrane GO:0016324 IMP     Golgi-associated vesicle membrane GO:0030660 TAS     clathrin-coated endocytic vesicle membrane GO:0030669 TAS     early endosome membrane GO:0031901 IEA     protein-containing complex GO:0032991 IDA     chloride channel complex GO:0034707 IEA     recycling endosome GO:0055037 IDA     recycling endosome membrane GO:0055038 IEA