Gene description for Prkaa1
Gene name	protein kinase, AMP-activated, alpha 1 catalytic subunit
Gene symbol	Prkaa1
Other names/aliases	AMPKalpha1
Species	Rattus norvegicus
Database cross references - Prkaa1
ExoCarta	ExoCarta_65248
Vesiclepedia	VP_65248
Entrez Gene	65248
UniProt	P54645
Prkaa1 identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Prkaa1

Molecular Function     chromatin binding GO:0003682 ISO     chromatin binding GO:0003682 ISS     protein kinase activity GO:0004672 ISO     protein serine/threonine kinase activity GO:0004674 IBA     protein serine/threonine kinase activity GO:0004674 IDA     protein serine/threonine kinase activity GO:0004674 ISO     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IDA     AMP-activated protein kinase activity GO:0004679 IEA     AMP-activated protein kinase activity GO:0004679 IMP     AMP-activated protein kinase activity GO:0004679 ISO     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     ribosomal protein S6 kinase activity GO:0004711 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IDA     ATP binding GO:0005524 IEA     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     eukaryotic elongation factor-2 kinase activator activity GO:0042557 NAS     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     protein-containing complex binding GO:0044877 IDA     metal ion binding GO:0046872 IEA     [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity GO:0047322 IEA     tau-protein kinase activity GO:0050321 IEA     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     histone H2BS36 kinase activity GO:0140823 ISO     histone H2BS36 kinase activity GO:0140823 ISS     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     positive regulation of T cell mediated immune response to tumor cell GO:0002842 ISO     glucose metabolic process GO:0006006 ISO     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 IDA     protein phosphorylation GO:0006468 NAS     fatty acid biosynthetic process GO:0006633 IEA     cholesterol biosynthetic process GO:0006695 IEA     autophagy GO:0006914 IEA     positive regulation of cell population proliferation GO:0008284 IDA     lipid biosynthetic process GO:0008610 ISO     lipid biosynthetic process GO:0008610 ISS     response to xenobiotic stimulus GO:0009410 IEP     response to UV GO:0009411 ISO     cold acclimation GO:0009631 IDA     response to gamma radiation GO:0010332 ISO     response to gamma radiation GO:0010332 ISS     positive regulation of autophagy GO:0010508 ISO     positive regulation of autophagy GO:0010508 ISS     positive regulation of gene expression GO:0010628 ISO     negative regulation of gene expression GO:0010629 ISO     response to activity GO:0014823 IDA     Wnt signaling pathway GO:0016055 IEA     negative regulation of translation GO:0017148 NAS     fatty acid oxidation GO:0019395 ISO     response to caffeine GO:0031000 IDA     cellular response to nutrient levels GO:0031669 ISO     cellular response to nutrient levels GO:0031669 ISS     negative regulation of TOR signaling GO:0032007 IBA     negative regulation of TOR signaling GO:0032007 ISO     negative regulation of TOR signaling GO:0032007 ISS     regulation of peptidyl-serine phosphorylation GO:0033135 ISO     cellular response to stress GO:0033554 ISO     cellular response to oxidative stress GO:0034599 ISO     cellular response to glucose starvation GO:0042149 IBA     cellular response to glucose starvation GO:0042149 ISO     cellular response to glucose starvation GO:0042149 ISS     response to hydrogen peroxide GO:0042542 ISO     glucose homeostasis GO:0042593 ISO     glucose homeostasis GO:0042593 ISS     regulation of circadian rhythm GO:0042752 ISO     regulation of circadian rhythm GO:0042752 ISS     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISS     response to estrogen GO:0043627 IEP     positive regulation of gluconeogenesis GO:0045722 NAS     positive regulation of glycolytic process GO:0045821 IDA     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of fatty acid oxidation GO:0046321 NAS     positive regulation of D-glucose import GO:0046326 NAS     negative regulation of insulin receptor signaling pathway GO:0046627 IMP     rhythmic process GO:0048511 IEA     positive regulation of skeletal muscle tissue development GO:0048643 ISO     positive regulation of T cell activation GO:0050870 ISO     negative regulation of lipid catabolic process GO:0050995 ISO     negative regulation of lipid catabolic process GO:0050995 ISS     fatty acid homeostasis GO:0055089 IDA     regulation of vesicle-mediated transport GO:0060627 IMP     motor behavior GO:0061744 ISO     CAMKK-AMPK signaling cascade GO:0061762 ISO     regulation of stress granule assembly GO:0062028 ISO     neuron cellular homeostasis GO:0070050 ISO     cellular response to hydrogen peroxide GO:0070301 IEP     regulation of microtubule cytoskeleton organization GO:0070507 ISO     cellular response to calcium ion GO:0071277 IMP     cellular response to calcium ion GO:0071277 ISO     cellular response to glucose stimulus GO:0071333 IMP     cellular response to glucose stimulus GO:0071333 ISO     cellular response to ethanol GO:0071361 IEP     cellular response to prostaglandin E stimulus GO:0071380 ISO     cellular response to hypoxia GO:0071456 IEP     cellular response to xenobiotic stimulus GO:0071466 IEP     energy homeostasis GO:0097009 IDA     energy homeostasis GO:0097009 ISO     positive regulation of mitochondrial transcription GO:1903109 ISO     positive regulation of protein localization GO:1903829 ISO     negative regulation of hepatocyte apoptotic process GO:1903944 ISO     negative regulation of hepatocyte apoptotic process GO:1903944 ISS     positive regulation of protein targeting to mitochondrion GO:1903955 ISO     positive regulation of adipose tissue development GO:1904179 ISO     negative regulation of TORC1 signaling GO:1904262 ISO     negative regulation of TORC1 signaling GO:1904262 ISS     negative regulation of tubulin deacetylation GO:1904428 ISO     lipid droplet disassembly GO:1905691 ISO     lipid droplet disassembly GO:1905691 ISS     protein localization to lipid droplet GO:1990044 ISO     protein localization to lipid droplet GO:1990044 ISS     positive regulation of peptidyl-lysine acetylation GO:2000758 ISO Subcellular Localization     chromatin GO:0000785 ISO     chromatin GO:0000785 ISO     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISO     cytosol GO:0005829 IDA     cytosol GO:0005829 ISO     cytosol GO:0005829 TAS     apical plasma membrane GO:0016324 IDA     nuclear speck GO:0016607 IEA     nuclear speck GO:0016607 ISO     axon GO:0030424 IMP     axon GO:0030424 ISO     dendrite GO:0030425 IMP     dendrite GO:0030425 ISO     nucleotide-activated protein kinase complex GO:0031588 IBA     nucleotide-activated protein kinase complex GO:0031588 IDA     nucleotide-activated protein kinase complex GO:0031588 ISO     protein-containing complex GO:0032991 IDA     neuronal cell body GO:0043025 IMP     neuronal cell body GO:0043025 ISO