Gene description for Tsc2
Gene name	tuberous sclerosis 2
Gene symbol	Tsc2
Other names/aliases	Rc
Species	Rattus norvegicus
Database cross references - Tsc2
ExoCarta	ExoCarta_24855
Vesiclepedia	VP_24855
Entrez Gene	24855
UniProt	P49816
Tsc2 identified in exosomes derived from the following tissue/cell type
Hepatocytes	19367702

Gene ontology annotations for Tsc2

Molecular Function     protein binding GO:0005515 IPI     protein heterodimerization activity GO:0046982 IPI     phosphatase binding GO:0019902 ISS     protein homodimerization activity GO:0042803 ISO     14-3-3 protein binding GO:0071889 ISO     GTPase activator activity GO:0005096 TAS Biological Process     negative regulation of protein kinase activity GO:0006469 ISO     cell projection organization GO:0030030 IMP     negative regulation of TOR signaling GO:0032007 ISO     protein homooligomerization GO:0051260 IMP     glucose import GO:0046323 ISO     protein transport into plasma membrane raft GO:0044861 ISO     protein heterooligomerization GO:0051291 IMP     insulin-like growth factor receptor signaling pathway GO:0048009 ISO     negative regulation of epithelial cell proliferation GO:0050680 IDA     cellular response to insulin stimulus GO:0032869 ISO     signal transduction GO:0007165 IDA     positive chemotaxis GO:0050918 ISO     negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067 ISO     heart development GO:0007507 ISO     positive regulation of GTPase activity GO:0043547 IEA     establishment of protein localization GO:0045184 IMP     protein kinase B signaling GO:0043491 ISO     regulation of cell cycle GO:0051726 IBA     negative regulation of insulin receptor signaling pathway GO:0046627 IBA     phosphatidylinositol 3-kinase signaling GO:0014065 ISO     response to hypoxia GO:0001666 ISO     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO     protein localization GO:0008104 ISO     regulation of endocytosis GO:0030100 ISO     negative regulation of MAP kinase activity GO:0043407 IMP     regulation of insulin receptor signaling pathway GO:0046626 ISO     negative regulation of cell proliferation GO:0008285 ISO     protein import into nucleus GO:0006606 ISO     neural tube closure GO:0001843 ISO     negative regulation of protein kinase B signaling GO:0051898 ISO     negative regulation of Wnt signaling pathway GO:0030178 IDA     negative regulation of cell size GO:0045792 IMP Subcellular Localization     dendrite GO:0030425 IDA     neuron projection GO:0043005 IDA     cytoskeleton GO:0005856 IDA     cytosol GO:0005829 ISO     protein complex GO:0043234 IDA     nucleus GO:0005634 ISO     caveola GO:0005901 IDA     growth cone GO:0030426 IDA     neuronal cell body GO:0043025 IDA     Golgi apparatus GO:0005794 ISO     intracellular GO:0005622 ISO     intracellular membrane-bounded organelle GO:0043231 IDA     cytoplasm GO:0005737 ISO     membrane raft GO:0045121 IDA     perinuclear region of cytoplasm GO:0048471 ISO     membrane GO:0016020 ISO     TSC1-TSC2 complex GO:0033596 ISO     cell GO:0005623 ISO