Gene description for PDZK1
Gene name PDZ domain containing 1
Gene symbol PDZK1
Other names/aliases CAP70
CLAMP
NHERF-3
NHERF3
PDZD1
Species Homo sapiens
 Database cross references - PDZK1
ExoCarta ExoCarta_5174
Entrez Gene 5174
HGNC 8821
MIM 603831
UniProt Q5T2W1  
 PDZK1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for PDZK1
Molecular Function
    PDZ domain binding GO:0030165 IPI
    protein complex binding GO:0032403 IEA
    transporter activity GO:0005215 TAS
    protein binding GO:0005515 IPI
    scavenger receptor binding GO:0005124 IEA
Biological Process
    regulation of anion transport GO:0044070 ISS
    positive regulation of ion transmembrane transport GO:0034767 IDA
    positive regulation of protein targeting to membrane GO:0090314 ISS
    cell proliferation GO:0008283 TAS
    drug transport GO:0015893 NAS
    transport GO:0006810 IDA
    carnitine transport GO:0015879 IDA
    establishment of protein localization to plasma membrane GO:0090002 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    microvillus membrane GO:0031528 IEA
    brush border membrane GO:0031526 ISS
    membrane raft GO:0045121 IEA
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 ISS
    apical plasma membrane GO:0016324 IEA
 Experiment description of studies that identified PDZK1 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 196
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 197
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PDZK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC9A3R2 9351
Two-hybrid Homo sapiens
2 PDZK1IP1 10158
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
3 ABCC2 1244
Two-hybrid Homo sapiens
4 GFAP 2670
Two-hybrid Homo sapiens
5 UBE2I 7329
Two-hybrid Homo sapiens
6 SLC9A3R1 9368
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
7 CFTR  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
8 SLC17A1  
Two-hybrid Homo sapiens
9 SLK 9748
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
10 SLC34A3  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
11 SLC22A4  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
12 SLC9A3 6550
Two-hybrid Homo sapiens
13 SCARB1 949
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
14 FARP2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
15 SLC22A12 116085
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
16 CLCN3 1182
Invitro Homo sapiens
Invivo Homo sapiens
17 PEX5  
Two-hybrid Homo sapiens
18 AKAP10  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which PDZK1 is involved
No pathways found





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