Gene description for PDZK1
Gene name PDZ domain containing 1
Gene symbol PDZK1
Other names/aliases CAP70
CLAMP
NHERF-3
NHERF3
PDZD1
Species Homo sapiens
 Database cross references - PDZK1
ExoCarta ExoCarta_5174
Vesiclepedia VP_5174
Entrez Gene 5174
HGNC 8821
MIM 603831
UniProt Q5T2W1  
 PDZK1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for PDZK1
Molecular Function
    signaling receptor binding GO:0005102 IBA
    scavenger receptor binding GO:0005124 IEA
    protein binding GO:0005515 IPI
    PDZ domain binding GO:0030165 IPI
    protein-membrane adaptor activity GO:0043495 IBA
    protein-containing complex binding GO:0044877 IEA
Biological Process
    carnitine transport GO:0015879 IDA
    positive regulation of ion transmembrane transporter activity GO:0032414 IDA
    regulation of monoatomic anion transport GO:0044070 ISS
    protein localization to plasma membrane GO:0072659 IBA
    positive regulation of protein targeting to membrane GO:0090314 ISS
    positive regulation of cation transmembrane transport GO:1904064 IDA
    positive regulation of protein localization to membrane GO:1905477 IMP
    xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 NAS
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    brush border GO:0005903 IDA
    apical plasma membrane GO:0016324 IBA
    brush border membrane GO:0031526 ISS
    microvillus membrane GO:0031528 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PDZK1 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 196
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 197
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PDZK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC4A7 9497
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 PTGIR  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 SHKBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ARHGAP17 55114
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ABCC2 1244
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
6 Ptgir 19222
Protein-peptide Mus musculus
Co-crystal Structure Mus musculus
7 AKAP10 11216
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
8 COLEC12 81035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SLC19A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ZBTB5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SLC9A3 6550
Two-hybrid Homo sapiens
12 AKT1 207
Affinity Capture-Western Homo sapiens
13 SLC22A12 116085
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
14 FRYL 285527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 EZR 7430
Co-fractionation Homo sapiens
16 SLC1A3 6507
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 GFAP 2670
Two-hybrid Homo sapiens
18 SLC22A5 6584
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ABCC4 10257
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 SLC9A3R2 9351
Two-hybrid Homo sapiens
21 CDK5RAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SLK 9748
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
23 SLC5A6 8884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 FARP2 9855
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
25 KCTD5 54442
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CLCN3 1182
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
27 Dlg4  
Two-hybrid Rattus norvegicus
28 APP 351
Reconstituted Complex Homo sapiens
29 KLHL17  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 APEX1 328
Affinity Capture-RNA Homo sapiens
31 ECI2 10455
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SH2D5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 UBE2I 7329
Two-hybrid Homo sapiens
34 ASNSD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ZBED1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 KLHL24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 SLC6A6 6533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 USP3 9960
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 SLC9A3R1 9368
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
41 DECR2 26063
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 KCTD17 79734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 PDZK1IP1 10158
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
44 OTULIN 90268
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PEX5 5830
Two-hybrid Homo sapiens
46 CFTR 1080
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 SLC17A1  
Two-hybrid Homo sapiens
48 SLC22A4 6583
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
49 Klhl17  
Two-hybrid Rattus norvegicus
50 KCTD3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 Syngap1  
Two-hybrid Rattus norvegicus
52 CDC37 11140
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 SCARB1 949
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 KCTD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 BCR 613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PDZK1 is involved
No pathways found





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