Gene description for BCR
Gene name breakpoint cluster region
Gene symbol BCR
Other names/aliases ALL
BCR1
CML
D22S11
D22S662
PHL
Species Homo sapiens
 Database cross references - BCR
ExoCarta ExoCarta_613
Vesiclepedia VP_613
Entrez Gene 613
HGNC 1014
MIM 151410
UniProt P11274  
 BCR identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Urine 19056867    
 Gene ontology annotations for BCR
Molecular Function
    enzyme binding GO:0019899 IEA
    protein tyrosine kinase activity GO:0004713 TAS
    Rho guanyl-nucleotide exchange factor activity GO:0005089 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    protein serine/threonine kinase activity GO:0004674 IEA
    kinase activity GO:0016301 TAS
    GTPase activator activity GO:0005096 IEA
Biological Process
    platelet-derived growth factor receptor signaling pathway GO:0048008 IEA
    brain development GO:0007420 IEA
    neuromuscular process controlling balance GO:0050885 IEA
    response to lipopolysaccharide GO:0032496 IEA
    negative regulation of cell migration GO:0030336 IEA
    negative regulation of inflammatory response GO:0050728 IEA
    positive regulation of phagocytosis GO:0050766 IEA
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    negative regulation of neutrophil degranulation GO:0043314 IEA
    protein autophosphorylation GO:0046777 IEA
    peptidyl-tyrosine phosphorylation GO:0018108 TAS
    actin cytoskeleton organization GO:0030036 IEA
    positive regulation of GTPase activity GO:0043547 TAS
    protein phosphorylation GO:0006468 TAS
    signal transduction GO:0007165 TAS
    inner ear morphogenesis GO:0042472 IEA
    small GTPase mediated signal transduction GO:0007264 TAS
    regulation of cell cycle GO:0051726 IEA
Subcellular Localization
    membrane GO:0016020 IDA
    cell junction GO:0030054 IEA
    cytosol GO:0005829 TAS
    postsynaptic membrane GO:0045211 IEA
    extracellular exosome GO:0070062 IDA
    postsynaptic density GO:0014069 ISS
    protein complex GO:0043234 IDA
 Experiment description of studies that identified BCR in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for BCR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MGC15730  
Two-hybrid Homo sapiens
2 GRB2 2885
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 SHC1 6464
Invitro Homo sapiens
4 PXN  
Co-purification Homo sapiens
5 TP53 7157
Two-hybrid Homo sapiens
6 PTPN6 5777
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 RB1 5925
Affinity Capture-Western Homo sapiens
8 HOXA9  
Phenotypic Enhancement Homo sapiens
9 ABL1 25
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
10 KIT 3815
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 Grb10  
Two-hybrid Mus musculus
12 SOS1 6654
Affinity Capture-Western Homo sapiens
13 GRB10 2887
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
14 HCK 3055
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 FES 2242
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
16 GAB2 9846
Affinity Capture-Western Homo sapiens
17 CBL 867
Co-purification Homo sapiens
18 ERCC3  
Far Western Homo sapiens
Two-hybrid Homo sapiens
19 MLLT4 4301
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
20 CRKL 1399
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 TLN1 7094
Co-purification Homo sapiens
22 SH2B1 25970
Affinity Capture-Western Homo sapiens
23 UNC119 9094
Two-hybrid Homo sapiens
24 PIK3CG  
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
25 JAK2 3717
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which BCR is involved
PathwayEvidenceSource
Rho GTPase cycle TAS Reactome
Signaling by FGFR1 fusion mutants TAS Reactome





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