Gene description for IL3
Gene name interleukin 3
Gene symbol IL3
Other names/aliases IL-3
MCGF
MULTI-CSF
Species Homo sapiens
 Database cross references - IL3
ExoCarta ExoCarta_3562
Entrez Gene 3562
HGNC 6011
MIM 147740
UniProt P08700  
 IL3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IL3
Molecular Function
    cytokine activity GO:0005125 IBA
    interleukin-3 receptor binding GO:0005135 TAS
    growth factor activity GO:0008083 IEA
Biological Process
    positive regulation of cell proliferation GO:0008284 ISS
    positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 IDA
    cytokine-mediated signaling pathway GO:0019221 IBA
    positive regulation of DNA replication GO:0045740 IDA
    nervous system development GO:0007399 TAS
    immune response GO:0006955 IEA
    positive regulation of mast cell proliferation GO:0070668 IBA
    embryonic hemopoiesis GO:0035162 IDA
    cell-cell signaling GO:0007267 TAS
    positive regulation of myeloid leukocyte differentiation GO:0002763 IBA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISS
Subcellular Localization
    extracellular space GO:0005615 ISS
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified IL3 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CSF2RB  
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
2 IL3RA  
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
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