Gene description for DOK1
Gene name
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Gene symbol
DOK1
Other names/aliases
P62DOK
Species
Homo sapiens
Database cross references - DOK1
ExoCarta
ExoCarta_1796
Entrez Gene
1796
HGNC
2990
MIM
602919
UniProt
Q99704
DOK1 identified in exosomes derived from the following tissue/cell type
Platelets
25332113
Platelets
25332113
Platelets
25332113
Gene ontology annotations for DOK1
Experiment description of studies that identified DOK1 in exosomes
1
Experiment ID
231
ISEV standards
✘
EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 1
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein Lipids
Methods used in the study
Western blotting Mass spectrometry
2
Experiment ID
232
ISEV standards
✘
EV Biophysical techniques
✘
EV Cytosolic markers
✘
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 2
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
3
Experiment ID
233
ISEV standards
✘
EV Biophysical techniques
✘
EV Cytosolic markers
✘
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 3
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for DOK1
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
LYN
4067
Biochemical Activity
Homo sapiens
Biochemical Activity
Homo sapiens
Reconstituted Complex
Homo sapiens
2
RASA1
5921
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
3
PTPRH
Invivo
Homo sapiens
4
TEC
7006
Affinity Capture-Western
Homo sapiens
Biochemical Activity
Homo sapiens
Biochemical Activity
Homo sapiens
Reconstituted Complex
Homo sapiens
5
SRC
6714
Reconstituted Complex
Homo sapiens
6
FGR
2268
Reconstituted Complex
Homo sapiens
7
DOK2
9046
Affinity Capture-Western
Homo sapiens
8
DOK1
1796
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
9
HCK
3055
Reconstituted Complex
Homo sapiens
10
CRKL
1399
Reconstituted Complex
Homo sapiens
11
NCK2
8440
Reconstituted Complex
Homo sapiens
12
INPP5D
3635
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
13
ABL1
25
Biochemical Activity
Homo sapiens
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
14
PLCG1
5335
Reconstituted Complex
Homo sapiens
15
SHC1
6464
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
16
KIT
3815
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
17
PIK3R1
5295
Reconstituted Complex
Homo sapiens
18
RET
5979
Two-hybrid
Homo sapiens
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
19
PTPN6
5777
Invivo
Homo sapiens
20
YES1
7525
Reconstituted Complex
Homo sapiens
21
SH2D1A
4068
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
View the network
image/svg+xml
Pathways in which DOK1 is involved