Gene description for DOK2
Gene name
docking protein 2, 56kDa
Gene symbol
DOK2
Other names/aliases
p56DOK p56dok-2
Species
Homo sapiens
Database cross references - DOK2
ExoCarta
ExoCarta_9046
Vesiclepedia
VP_9046
Entrez Gene
9046
HGNC
2991
MIM
604997
UniProt
O60496
DOK2 identified in exosomes derived from the following tissue/cell type
Platelets
25332113
Platelets
25332113
Platelets
25332113
Thymus
23844026
Gene ontology annotations for DOK2
Experiment description of studies that identified DOK2 in exosomes
1
Experiment ID
231
MISEV standards
✘
EV Biophysical techniques
✔
Alix|CD63|CD9
EV Enriched markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 1
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein Lipids
Methods used in the study
Western blotting Mass spectrometry
2
Experiment ID
232
MISEV standards
✘
EV Biophysical techniques
✘
EV Enriched markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 2
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
3
Experiment ID
233
MISEV standards
✘
EV Biophysical techniques
✘
EV Enriched markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 3
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
4
Experiment ID
217
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|CD81|CD9|CD63
EV Enriched markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23844026
Organism
Homo sapiens
Experiment description
Characterization of human thymic exosomes.
Authors
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name
PLoS One
Publication year
2013
Sample
Thymus
Sample name
Normal-Thymus
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for DOK2
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
RAB10
10890
Affinity Capture-MS
Homo sapiens
2
RASA1
5921
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
3
TEK
Affinity Capture-Western
Homo sapiens
4
KIF1BP
26128
Two-hybrid
Homo sapiens
5
DOK1
1796
Affinity Capture-Western
Homo sapiens
6
HSPA4L
22824
Affinity Capture-MS
Homo sapiens
7
LCK
3932
Affinity Capture-MS
Homo sapiens
8
SPOP
Affinity Capture-MS
Homo sapiens
9
INPP5D
3635
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
10
NCK1
4690
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
Invitro
Homo sapiens
11
PSMD10
5716
Affinity Capture-MS
Homo sapiens
12
CFLAR
Affinity Capture-MS
Homo sapiens
13
EGFR
1956
Reconstituted Complex
Homo sapiens
14
SHC1
6464
Affinity Capture-Western
Homo sapiens
15
RET
5979
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
16
DNAJB11
51726
Affinity Capture-MS
Homo sapiens
17
SSSCA1
10534
Affinity Capture-MS
Homo sapiens
18
ASF1B
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which DOK2 is involved