Gene description for PLCG1
Gene name phospholipase C, gamma 1
Gene symbol PLCG1
Other names/aliases NCKAP3
PLC-II
PLC1
PLC148
PLCgamma1
Species Homo sapiens
 Database cross references - PLCG1
ExoCarta ExoCarta_5335
Entrez Gene 5335
HGNC 9065
MIM 172420
UniProt P19174  
 PLCG1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PLCG1
Molecular Function
    calcium ion binding GO:0005509 IEA
    glutamate receptor binding GO:0035254 IEA
    receptor signaling protein activity GO:0005057 NAS
    protein kinase binding GO:0019901 IPI
    phospholipase C activity GO:0004629 TAS
    receptor tyrosine kinase binding GO:0030971 IEA
    neurotrophin TRKA receptor binding GO:0005168 IPI
    phosphatidylinositol phospholipase C activity GO:0004435 TAS
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of epithelial cell migration GO:0010634 IMP
    calcium-mediated signaling GO:0019722 IMP
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    in utero embryonic development GO:0001701 IEA
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    inositol phosphate metabolic process GO:0043647 TAS
    small molecule metabolic process GO:0044281 TAS
    axon guidance GO:0007411 TAS
    blood coagulation GO:0007596 TAS
    activation of MAPKK activity GO:0000186 TAS
    T cell receptor signaling pathway GO:0050852 TAS
    cell migration GO:0016477 IMP
    innate immune response GO:0045087 TAS
    activation of phospholipase C activity GO:0007202 TAS
    signal transduction GO:0007165 TAS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    phospholipid catabolic process GO:0009395 IEA
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    positive regulation of blood vessel endothelial cell migration GO:0043536 IDA
    cytokine-mediated signaling pathway GO:0019221 TAS
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IMP
    positive regulation of angiogenesis GO:0045766 IDA
    viral process GO:0016032 IEA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    leukocyte migration GO:0050900 TAS
    cellular response to epidermal growth factor stimulus GO:0071364 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cell-cell junction GO:0005911 IEA
    plasma membrane GO:0005886 TAS
    cell projection GO:0042995 IDA
    cytosol GO:0005829 TAS
    lamellipodium GO:0030027 IDA
    ruffle GO:0001726 IDA
    COP9 signalosome GO:0008180 IDA
 Experiment description of studies that identified PLCG1 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PLCG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDGFA 5154
Affinity Capture-Western Homo sapiens
2 LAT 27040
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
3 PKN2 5586
Reconstituted Complex Homo sapiens
4 RASA1 5921
Affinity Capture-Western Homo sapiens
5 ERBB2 2064
Invivo Homo sapiens
Invivo Homo sapiens
6 FGFR1 2260
Two-hybrid Homo sapiens
7 PDGFRA  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
8 GNB2L1 10399
Invivo Homo sapiens
Invitro Homo sapiens
9 GRB2 2885
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
10 EEF1A1 1915
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 RICS  
Affinity Capture-Western Homo sapiens
12 BAG3  
Invivo Homo sapiens
Invitro Homo sapiens
13 CD22 933
Invitro Homo sapiens
14 TRPM7  
Invitro Homo sapiens
Two-hybrid Homo sapiens
15 CTSS  
Invivo Homo sapiens
Invitro Homo sapiens
16 PECAM1 5175
Invitro Homo sapiens
17 MST1R 4486
Invivo Homo sapiens
18 KIT 3815
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
19 VAV1 7409
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 PTK2 5747
Affinity Capture-Western Homo sapiens
21 PRKD1 5587
Affinity Capture-Western Homo sapiens
22 EGFR 1956
Invivo Homo sapiens
23 TUB  
Invivo Homo sapiens
Invitro Homo sapiens
24 RET 5979
Invivo Homo sapiens
Invitro Homo sapiens
25 PDGFRB 5159
Affinity Capture-Western Homo sapiens
26 LAT2 7462
Affinity Capture-Western Homo sapiens
27 SOCS7  
Invitro Homo sapiens
28 GAB1  
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
29 FGFR2 2263
Invivo Homo sapiens
30 CBL 867
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
31 PITPNA 5306
Invivo Homo sapiens
Invitro Homo sapiens
32 SNAP91  
Invivo Homo sapiens
Invitro Homo sapiens
33 DOK1 1796
Reconstituted Complex Homo sapiens
34 LIFR 3977
Invivo Homo sapiens
35 DGKZ  
Affinity Capture-Western Homo sapiens
36 TNK1  
Invitro Homo sapiens
37 GIT1 28964
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
38 NTRK1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
39 PTPRJ 5795
Invitro Homo sapiens
40 SELE  
Affinity Capture-Western Homo sapiens
41 LCP2 3937
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
42 SHB  
Affinity Capture-Western Homo sapiens
43 ZAP70 7535
Affinity Capture-Western Homo sapiens
44 SYNCRIP 10492
Reconstituted Complex Homo sapiens
45 SOS2 6655
Invivo Homo sapiens
Two-hybrid Homo sapiens
46 WAS 7454
Reconstituted Complex Homo sapiens
47 PAK1  
Reconstituted Complex Homo sapiens
48 SRC 6714
Affinity Capture-Western Homo sapiens
49 ITK 3702
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
50 KHDRBS1 10657
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
51 SYK 6850
Affinity Capture-Western Homo sapiens
52 SH3BP2  
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
53 NTRK2 4915
Reconstituted Complex Homo sapiens
54 NTRK3  
Reconstituted Complex Homo sapiens
55 RHOA 387
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
56 SOS1  
Invitro Homo sapiens
57 PICALM 8301
Invitro Homo sapiens
58 PLD2 5338
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
59 ALK 238
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
60 IRS2 8660
Invivo Homo sapiens
61 SHC1 6464
Affinity Capture-Western Homo sapiens
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