Gene description for FGFR1
Gene name fibroblast growth factor receptor 1
Gene symbol FGFR1
Other names/aliases BFGFR
CD331
CEK
FGFBR
FGFR-1
FLG
FLT-2
FLT2
HBGFR
HH2
HRTFDS
KAL2
N-SAM
OGD
bFGF-R-1
Species Homo sapiens
 Database cross references - FGFR1
ExoCarta ExoCarta_2260
Entrez Gene 2260
HGNC 3688
MIM 136350
UniProt P11362  
 FGFR1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FGFR1
Molecular Function
    protein tyrosine kinase activity GO:0004713 IDA
    fibroblast growth factor-activated receptor activity GO:0005007 TAS
    ATP binding GO:0005524 IEA
    protein homodimerization activity GO:0042803 IPI
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IDA
    identical protein binding GO:0042802 IPI
    fibroblast growth factor binding GO:0017134 IDA
Biological Process
    chordate embryonic development GO:0043009 TAS
    positive regulation of MAP kinase activity GO:0043406 IDA
    middle ear morphogenesis GO:0042474 IEA
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 TAS
    embryonic limb morphogenesis GO:0030326 IEA
    midbrain development GO:0030901 IEA
    regulation of lateral mesodermal cell fate specification GO:0048378 IEA
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    neuron migration GO:0001764 TAS
    organ induction GO:0001759 IEA
    ventricular zone neuroblast division GO:0021847 IEA
    protein autophosphorylation GO:0046777 IDA
    cell maturation GO:0048469 IEA
    protein phosphorylation GO:0006468 NAS
    axon guidance GO:0007411 TAS
    ureteric bud development GO:0001657 IEA
    angiogenesis GO:0001525 IEA
    positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 IEA
    skeletal system development GO:0001501 TAS
    positive regulation of cardiac muscle cell proliferation GO:0060045 IEA
    auditory receptor cell development GO:0060117 IEA
    lung-associated mesenchyme development GO:0060484 IEA
    fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0035607 IEA
    cell migration GO:0016477 TAS
    in utero embryonic development GO:0001701 IEA
    positive regulation of MAPK cascade GO:0043410 IMP
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    MAPK cascade GO:0000165 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    branching involved in salivary gland morphogenesis GO:0060445 IEA
    positive regulation of cell proliferation GO:0008284 IMP
    skeletal system morphogenesis GO:0048705 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    positive regulation of phospholipase C activity GO:0010863 IDA
    outer ear morphogenesis GO:0042473 IEA
    regulation of cell differentiation GO:0045595 TAS
    positive regulation of neuron differentiation GO:0045666 IMP
    insulin receptor signaling pathway GO:0008286 TAS
    positive regulation of phospholipase activity GO:0010518 TAS
    positive regulation of mesenchymal cell proliferation GO:0002053 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    paraxial mesoderm development GO:0048339 IEA
    regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 IEA
    sensory perception of sound GO:0007605 IEA
    regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    transcription, DNA-templated GO:0006351 IEA
    innate immune response GO:0045087 TAS
    positive regulation of cell cycle GO:0045787 IEA
    inner ear morphogenesis GO:0042472 IEA
    chondrocyte differentiation GO:0002062 IEA
    mesenchymal cell differentiation GO:0048762 IEA
    positive regulation of neuron projection development GO:0010976 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 TAS
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    receptor complex GO:0043235 IDA
    integral component of membrane GO:0016021 NAS
    integral component of plasma membrane GO:0005887 TAS
    nucleus GO:0005634 IEA
    extracellular region GO:0005576 NAS
 Experiment description of studies that identified FGFR1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FGFR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NCAM1 4684
Affinity Capture-Western Homo sapiens
2 KPNB1 3837
Invivo Homo sapiens
3 PLCG1 5335
Two-hybrid Homo sapiens
4 FGF1  
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
5 FRS2  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
6 FGFR1 2260
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
7 FGF5  
Invivo Homo sapiens
8 GRB2 2885
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
9 SHC1 6464
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
10 FGF2 2247
Invivo Homo sapiens
Invitro Homo sapiens
11 FDPS 2224
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
12 GRB14  
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
13 SHB  
Invivo Homo sapiens
Invitro Homo sapiens
14 BNIP2  
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
15 FRS3  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FGFR1 is involved
PathwayEvidenceSource
Signaling by activated point mutants of FGFR1 TAS Reactome
Signaling by FGFR1 mutants TAS Reactome





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