Gene description for FGFR1
Gene name fibroblast growth factor receptor 1
Gene symbol FGFR1
Other names/aliases BFGFR
CD331
CEK
FGFBR
FGFR-1
FLG
FLT-2
FLT2
HBGFR
HH2
HRTFDS
KAL2
N-SAM
OGD
bFGF-R-1
Species Homo sapiens
 Database cross references - FGFR1
ExoCarta ExoCarta_2260
Vesiclepedia VP_2260
Entrez Gene 2260
HGNC 3688
MIM 136350
UniProt P11362  
 FGFR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FGFR1
Molecular Function
    protein tyrosine kinase activity GO:0004713 IDA
    fibroblast growth factor-activated receptor activity GO:0005007 TAS
    ATP binding GO:0005524 IEA
    protein homodimerization activity GO:0042803 IPI
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IDA
    identical protein binding GO:0042802 IPI
    fibroblast growth factor binding GO:0017134 IDA
Biological Process
    chordate embryonic development GO:0043009 TAS
    positive regulation of MAP kinase activity GO:0043406 IDA
    middle ear morphogenesis GO:0042474 IEA
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 TAS
    embryonic limb morphogenesis GO:0030326 IEA
    midbrain development GO:0030901 IEA
    regulation of lateral mesodermal cell fate specification GO:0048378 IEA
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    neuron migration GO:0001764 TAS
    organ induction GO:0001759 IEA
    ventricular zone neuroblast division GO:0021847 IEA
    protein autophosphorylation GO:0046777 IDA
    cell maturation GO:0048469 IEA
    protein phosphorylation GO:0006468 NAS
    axon guidance GO:0007411 TAS
    ureteric bud development GO:0001657 IEA
    angiogenesis GO:0001525 IEA
    positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 IEA
    skeletal system development GO:0001501 TAS
    positive regulation of cardiac muscle cell proliferation GO:0060045 IEA
    auditory receptor cell development GO:0060117 IEA
    lung-associated mesenchyme development GO:0060484 IEA
    fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0035607 IEA
    cell migration GO:0016477 TAS
    in utero embryonic development GO:0001701 IEA
    positive regulation of MAPK cascade GO:0043410 IMP
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    MAPK cascade GO:0000165 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    branching involved in salivary gland morphogenesis GO:0060445 IEA
    positive regulation of cell proliferation GO:0008284 IMP
    skeletal system morphogenesis GO:0048705 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    positive regulation of phospholipase C activity GO:0010863 IDA
    outer ear morphogenesis GO:0042473 IEA
    regulation of cell differentiation GO:0045595 TAS
    positive regulation of neuron differentiation GO:0045666 IMP
    insulin receptor signaling pathway GO:0008286 TAS
    positive regulation of phospholipase activity GO:0010518 TAS
    positive regulation of mesenchymal cell proliferation GO:0002053 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    paraxial mesoderm development GO:0048339 IEA
    regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 IEA
    sensory perception of sound GO:0007605 IEA
    regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    transcription, DNA-templated GO:0006351 IEA
    innate immune response GO:0045087 TAS
    positive regulation of cell cycle GO:0045787 IEA
    inner ear morphogenesis GO:0042472 IEA
    chondrocyte differentiation GO:0002062 IEA
    mesenchymal cell differentiation GO:0048762 IEA
    positive regulation of neuron projection development GO:0010976 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 TAS
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    receptor complex GO:0043235 IDA
    integral component of membrane GO:0016021 NAS
    integral component of plasma membrane GO:0005887 TAS
    nucleus GO:0005634 IEA
    extracellular region GO:0005576 NAS
 Experiment description of studies that identified FGFR1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 211
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
EV Enriched markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
EV Enriched markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FGFR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GRB14 2888
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
2 NCAM1 4684
Affinity Capture-Western Homo sapiens
3 KPNB1 3837
Invivo Homo sapiens
4 SHB 6461
Invivo Homo sapiens
Invitro Homo sapiens
5 FGF1  
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
6 FRS3 10817
Two-hybrid Homo sapiens
7 PLCG1 5335
Two-hybrid Homo sapiens
8 FGFR1 2260
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
9 FGF5  
Invivo Homo sapiens
10 GRB2 2885
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
11 SHC1 6464
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
12 FDPS 2224
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
13 FRS2 10818
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
14 FGF2 2247
Invivo Homo sapiens
Invitro Homo sapiens
15 BNIP2  
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FGFR1 is involved
PathwayEvidenceSource
Signaling by activated point mutants of FGFR1 TAS Reactome
Signaling by FGFR1 mutants TAS Reactome





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