Gene description for FGFR1
Gene name fibroblast growth factor receptor 1
Gene symbol FGFR1
Other names/aliases BFGFR
CD331
CEK
FGFBR
FGFR-1
FLG
FLT-2
FLT2
HBGFR
HH2
HRTFDS
KAL2
N-SAM
OGD
bFGF-R-1
Species Homo sapiens
 Database cross references - FGFR1
ExoCarta ExoCarta_2260
Vesiclepedia VP_2260
Entrez Gene 2260
HGNC 3688
MIM 136350
UniProt P11362  
 FGFR1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FGFR1
Molecular Function
    protein tyrosine kinase activity GO:0004713 IDA
    GPI-linked ephrin receptor activity GO:0005004 IEA
    transmembrane-ephrin receptor activity GO:0005005 IEA
    epidermal growth factor receptor activity GO:0005006 IEA
    fibroblast growth factor receptor activity GO:0005007 IBA
    fibroblast growth factor receptor activity GO:0005007 IDA
    fibroblast growth factor receptor activity GO:0005007 TAS
    hepatocyte growth factor receptor activity GO:0005008 IEA
    insulin receptor activity GO:0005009 IEA
    insulin-like growth factor receptor activity GO:0005010 IEA
    macrophage colony-stimulating factor receptor activity GO:0005011 IEA
    platelet-derived growth factor alpha-receptor activity GO:0005018 IEA
    platelet-derived growth factor beta-receptor activity GO:0005019 IEA
    stem cell factor receptor activity GO:0005020 IEA
    vascular endothelial growth factor receptor activity GO:0005021 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    heparin binding GO:0008201 IDA
    boss receptor activity GO:0008288 IEA
    fibroblast growth factor binding GO:0017134 IBA
    fibroblast growth factor binding GO:0017134 IDA
    histone H3Y41 kinase activity GO:0035401 IEA
    placental growth factor receptor activity GO:0036332 IEA
    protein tyrosine kinase collagen receptor activity GO:0038062 IEA
    SH2 domain binding GO:0042169 IEA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IPI
    brain-derived neurotrophic factor receptor activity GO:0060175 IEA
    receptor-receptor interaction GO:0090722 IDA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    MAPK cascade GO:0000165 TAS
    skeletal system development GO:0001501 TAS
    angiogenesis GO:0001525 IEA
    ureteric bud development GO:0001657 IEA
    in utero embryonic development GO:0001701 IEA
    organ induction GO:0001759 IEA
    neuron migration GO:0001764 TAS
    epithelial to mesenchymal transition GO:0001837 IMP
    positive regulation of mesenchymal cell proliferation GO:0002053 IEA
    chondrocyte differentiation GO:0002062 IEA
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 NAS
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    multicellular organism development GO:0007275 IBA
    sensory perception of sound GO:0007605 IEA
    positive regulation of cell population proliferation GO:0008284 IDA
    positive regulation of cell population proliferation GO:0008284 IGI
    positive regulation of cell population proliferation GO:0008284 IMP
    insulin receptor signaling pathway GO:0008286 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IDA
    fibroblast growth factor receptor signaling pathway GO:0008543 IGI
    fibroblast growth factor receptor signaling pathway GO:0008543 IPI
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    mesenchymal cell proliferation GO:0010463 IEA
    gene expression GO:0010467 IEA
    positive regulation of phospholipase activity GO:0010518 TAS
    regulation of phosphate transport GO:0010966 IEA
    positive regulation of neuron projection development GO:0010976 IEA
    cell migration GO:0016477 TAS
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    ventricular zone neuroblast division GO:0021847 IEA
    cell projection assembly GO:0030031 IEA
    embryonic limb morphogenesis GO:0030326 IEA
    midbrain development GO:0030901 IEA
    neuron projection development GO:0031175 IEA
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA
    fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0035607 IEA
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA
    vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    Kit signaling pathway GO:0038109 IEA
    macrophage colony-stimulating factor signaling pathway GO:0038145 IEA
    inner ear morphogenesis GO:0042472 IEA
    outer ear morphogenesis GO:0042473 IEA
    middle ear morphogenesis GO:0042474 IEA
    chordate embryonic development GO:0043009 TAS
    positive regulation of MAP kinase activity GO:0043406 IDA
    positive regulation of MAPK cascade GO:0043410 IGI
    positive regulation of MAPK cascade GO:0043410 IMP
    positive regulation of blood vessel endothelial cell migration GO:0043536 IGI
    cellular response to fibroblast growth factor stimulus GO:0044344 IDA
    regulation of cell differentiation GO:0045595 TAS
    positive regulation of cell differentiation GO:0045597 IBA
    positive regulation of neuron differentiation GO:0045666 IMP
    protein autophosphorylation GO:0046777 IDA
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    hepatocyte growth factor receptor signaling pathway GO:0048012 IEA
    ephrin receptor signaling pathway GO:0048013 IEA
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    paraxial mesoderm development GO:0048339 IEA
    regulation of lateral mesodermal cell fate specification GO:0048378 IEA
    cell maturation GO:0048469 IEA
    skeletal system morphogenesis GO:0048705 TAS
    stem cell differentiation GO:0048863 IEA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IGI
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 TAS
    calcium ion homeostasis GO:0055074 IEA
    cardiac muscle cell proliferation GO:0060038 IEA
    positive regulation of cardiac muscle cell proliferation GO:0060045 IEA
    auditory receptor cell development GO:0060117 IEA
    branching involved in salivary gland morphogenesis GO:0060445 IEA
    lung-associated mesenchyme development GO:0060484 IEA
    regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 IEA
    vitamin D3 metabolic process GO:0070640 IEA
    diphosphate metabolic process GO:0071344 IEA
    cementum mineralization GO:0071529 IEA
    stem cell proliferation GO:0072089 IEA
    positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 IEA
    negative regulation of fibroblast growth factor production GO:0090272 IEA
    regulation of postsynaptic density assembly GO:0099151 IEA
    positive regulation of mitotic cell cycle DNA replication GO:1903465 IEA
    response to sodium phosphate GO:1904383 IEA
    positive regulation of vascular endothelial cell proliferation GO:1905564 IGI
    positive regulation of stem cell proliferation GO:2000648 IEA
    positive regulation of parathyroid hormone secretion GO:2000830 IEA
    positive regulation of endothelial cell chemotaxis GO:2001028 IDA
    regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 IEA
Subcellular Localization
    extracellular region GO:0005576 NAS
    nucleus GO:0005634 IEA
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 NAS
    cytoplasmic vesicle GO:0031410 IEA
    receptor complex GO:0043235 IBA
    receptor complex GO:0043235 IDA
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified FGFR1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FGFR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 SEC22B 9554
Affinity Capture-MS Homo sapiens
3 RAET1E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 IZUMO1  
Affinity Capture-MS Homo sapiens
5 MTCH1 23787
Affinity Capture-MS Homo sapiens
6 RAB1A 5861
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
7 SHC1 6464
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
8 HSPA6 3310
Affinity Capture-MS Homo sapiens
9 CD8B 926
Affinity Capture-MS Homo sapiens
10 FRS3 10817
Two-hybrid Homo sapiens
11 TH  
Co-localization Homo sapiens
12 CTPS2 56474
Two-hybrid Homo sapiens
13 PKM 5315
Affinity Capture-MS Homo sapiens
14 P2RX4 5025
Affinity Capture-MS Homo sapiens
15 IL20RB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 LRRN2 10446
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CRK 1398
Co-localization Homo sapiens
18 KPNB1 3837
Affinity Capture-Western Homo sapiens
19 FGF4  
Reconstituted Complex Homo sapiens
20 HSPA1L 3305
Affinity Capture-MS Homo sapiens
21 ANK1 286
Affinity Capture-MS Homo sapiens
22 SHB 6461
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
23 IFNGR1 3459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 FGF3  
Protein-peptide Homo sapiens
25 COPA 1314
Affinity Capture-MS Homo sapiens
26 CDH2 1000
Affinity Capture-Western Homo sapiens
27 HEPACAM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CD83  
Affinity Capture-MS Homo sapiens
29 APEX1 328
Affinity Capture-RNA Homo sapiens
30 RPS6KA3 6197
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
31 FGF23  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
32 AFAP1 60312
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
33 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
34 PLCG2 5336
Affinity Capture-MS Homo sapiens
35 KCNC3 3748
Affinity Capture-MS Homo sapiens
36 FGF5  
Protein-peptide Homo sapiens
37 GRB14 2888
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
38 HSPA2 3306
Affinity Capture-MS Homo sapiens
39 FRS2 10818
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
40 FAM8A1 51439
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 GINM1 116254
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 YES1 7525
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
43 GNB1 2782
Affinity Capture-MS Homo sapiens
44 ZDHHC11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PCDHB7  
Affinity Capture-MS Homo sapiens
46 STAT3 6774
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
47 CDH16  
Affinity Capture-MS Homo sapiens
48 SRC 6714
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
49 FGF17  
Protein-peptide Homo sapiens
50 ANOS1 3730
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
51 PLCG1 5335
Two-hybrid Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
52 RTN1 6252
Two-hybrid Homo sapiens
53 ARF4 378
Affinity Capture-MS Homo sapiens
54 RCN2 5955
Affinity Capture-MS Homo sapiens
55 AVPR1B  
Affinity Capture-MS Homo sapiens
56 VDAC1 7416
Affinity Capture-MS Homo sapiens
57 L1CAM 3897
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
58 PHB 5245
Affinity Capture-MS Homo sapiens
59 MLC1 23209
Affinity Capture-MS Homo sapiens
60 LDLRAD4  
Affinity Capture-MS Homo sapiens
61 ERBB2 2064
PCA Homo sapiens
62 FGFR1 2260
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
63 NEDD4 4734
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
64 TMEM59 9528
Affinity Capture-MS Homo sapiens
65 C19orf45  
Affinity Capture-MS Homo sapiens
66 STX12 23673
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
67 FGF10  
Protein-peptide Homo sapiens
68 FGF2 2247
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
69 DEFB109P1B  
Affinity Capture-MS Homo sapiens
70 LTBR 4055
Affinity Capture-MS Homo sapiens
71 ACTG1 71
Affinity Capture-MS Homo sapiens
72 STOML2 30968
Affinity Capture-MS Homo sapiens
73 IL32  
Affinity Capture-MS Homo sapiens
74 SYT2  
Affinity Capture-MS Homo sapiens
75 MANSC1 54682
Affinity Capture-MS Homo sapiens
76 NCAM1 4684
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
77 VAV1 7409
Protein-peptide Homo sapiens
78 PTPRN2  
Affinity Capture-MS Homo sapiens
79 NRSN1  
Affinity Capture-MS Homo sapiens
80 RAB14 51552
Affinity Capture-MS Homo sapiens
81 CEACAM21  
Affinity Capture-MS Homo sapiens
82 PDGFRB 5159
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
83 ERBB3 2065
Protein-peptide Homo sapiens
84 RAB15 376267
Affinity Capture-MS Homo sapiens
85 FGF9  
Protein-peptide Homo sapiens
86 TSPAN3 10099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 RAB4A 5867
Affinity Capture-MS Homo sapiens
88 PTK6  
Protein-peptide Homo sapiens
89 MKRN2 23609
Affinity Capture-RNA Homo sapiens
90 TUBA1B 10376
Affinity Capture-MS Homo sapiens
91 SH3BP2  
Two-hybrid Homo sapiens
92 CSNK1G2 1455
Affinity Capture-MS Homo sapiens
93 C16orf58 64755
Affinity Capture-MS Homo sapiens
94 FGF8  
Co-localization Homo sapiens
Protein-peptide Homo sapiens
95 RAP1A 5906
Affinity Capture-MS Homo sapiens
96 IL27RA 9466
Affinity Capture-MS Homo sapiens
97 FLRT1  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
98 CDHR4  
Affinity Capture-MS Homo sapiens
99 DNAJB1 3337
Affinity Capture-MS Homo sapiens
100 DHFRL1  
Affinity Capture-MS Homo sapiens
101 ITK 3702
Protein-peptide Homo sapiens
102 RAB11B 9230
Affinity Capture-MS Homo sapiens
103 SCN3B  
Affinity Capture-MS Homo sapiens
104 DNAJC13 23317
Affinity Capture-MS Homo sapiens
105 VDAC2 7417
Affinity Capture-MS Homo sapiens
106 DDOST 1650
Affinity Capture-MS Homo sapiens
107 ATP5B 506
Affinity Capture-MS Homo sapiens
108 RPS6KA1 6195
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
109 PARD3 56288
Affinity Capture-MS Homo sapiens
110 PCDHA8  
Affinity Capture-MS Homo sapiens
111 C7orf34  
Affinity Capture-MS Homo sapiens
112 Il17rd  
Affinity Capture-Western Mus musculus
113 GJA8  
Affinity Capture-MS Homo sapiens
114 PTPN11 5781
Affinity Capture-Western Homo sapiens
115 CRKL 1399
Affinity Capture-Western Homo sapiens
116 RXRA 6256
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
117 TMED9 54732
Affinity Capture-MS Homo sapiens
118 BAX 581
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
119 CANX 821
Affinity Capture-MS Homo sapiens
120 RAB7A 7879
Affinity Capture-MS Homo sapiens
121 SLA  
Two-hybrid Homo sapiens
122 RAB5A 5868
Affinity Capture-MS Homo sapiens
123 PVRL1 5818
Reconstituted Complex Homo sapiens
124 CD79B 974
Affinity Capture-MS Homo sapiens
125 CLPTM1 1209
Affinity Capture-MS Homo sapiens
126 EPB41L4A 64097
Affinity Capture-MS Homo sapiens
127 CTNNB1 1499
Co-localization Homo sapiens
128 BNIP2  
Biochemical Activity Homo sapiens
129 FGF6  
Protein-peptide Homo sapiens
130 CLEC4A  
Affinity Capture-MS Homo sapiens
131 Nr4a2  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
132 TBXA2R 6915
Affinity Capture-MS Homo sapiens
133 GAB1  
Affinity Capture-Western Homo sapiens
134 CTSG 1511
Affinity Capture-MS Homo sapiens
135 TUBA4A 7277
Affinity Capture-MS Homo sapiens
136 KCNE3  
Affinity Capture-MS Homo sapiens
137 FGFR2 2263
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 MREG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 IFNAR1  
Affinity Capture-MS Homo sapiens
140 RAB2B 84932
Affinity Capture-MS Homo sapiens
141 FBXO2 26232
Affinity Capture-MS Homo sapiens
142 FDPS 2224
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
143 RAB9A 9367
Affinity Capture-MS Homo sapiens
144 TNS2 23371
Two-hybrid Homo sapiens
145 C1QTNF9B  
Affinity Capture-MS Homo sapiens
146 CDC37 11140
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
147 OPCML  
Affinity Capture-Western Homo sapiens
148 RPN1 6184
Affinity Capture-MS Homo sapiens
149 EVI2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 KTN1 3895
Cross-Linking-MS (XL-MS) Homo sapiens
151 TPCN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 LGALS8 3964
Affinity Capture-MS Homo sapiens
153 AKT1 207
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
154 PDP1 54704
Reconstituted Complex Homo sapiens
155 ZMYM2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
156 PIK3R1 5295
Co-localization Homo sapiens
Two-hybrid Homo sapiens
157 PHGDH 26227
Affinity Capture-MS Homo sapiens
158 AQP9  
Affinity Capture-MS Homo sapiens
159 IMMT 10989
Affinity Capture-MS Homo sapiens
160 CRLF2 64109
Affinity Capture-MS Homo sapiens
161 TNK2 10188
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
162 NCK1 4690
Protein-peptide Homo sapiens
163 RARA 5914
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
164 BCAN  
Affinity Capture-MS Homo sapiens
165 CDC20 991
Affinity Capture-MS Homo sapiens
166 SLC25A6 293
Affinity Capture-MS Homo sapiens
167 TGFBR2 7048
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 H3F3A 3020
Co-localization Homo sapiens
169 PGRMC1 10857
Affinity Capture-MS Homo sapiens
170 RTN3 10313
Two-hybrid Homo sapiens
171 RUVBL2 10856
Affinity Capture-MS Homo sapiens
172 FCGRT 2217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 EPHA4 2043
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
174 MFI2 4241
Affinity Capture-MS Homo sapiens
175 GAD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
176 TMEM30B 161291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
177 LITAF 9516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
178 CDH1 999
Co-localization Homo sapiens
179 SOS1 6654
Co-localization Homo sapiens
180 CREBBP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
181 DLK1  
Affinity Capture-MS Homo sapiens
182 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
183 OR1M1  
Affinity Capture-MS Homo sapiens
184 GOLGA7B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
185 DDX58 23586
Affinity Capture-RNA Homo sapiens
186 IL3RA  
Affinity Capture-MS Homo sapiens
187 TUBB4A 10382
Affinity Capture-MS Homo sapiens
188 NCK2 8440
Two-hybrid Homo sapiens
189 SFTPC  
Affinity Capture-MS Homo sapiens
190 RAB8A 4218
Affinity Capture-MS Homo sapiens
191 TNFRSF10B 8795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 FGF1  
Co-crystal Structure Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
193 ACTA1 58
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
194 TSHR 7253
Affinity Capture-MS Homo sapiens
195 LMAN2 10960
Affinity Capture-MS Homo sapiens
196 Nr4a1  
Co-localization Mus musculus
197 UGT1A7 54577
Affinity Capture-MS Homo sapiens
198 CDK9 1025
Affinity Capture-MS Homo sapiens
199 TMEM109 79073
Affinity Capture-MS Homo sapiens
200 DEFB135  
Affinity Capture-MS Homo sapiens
201 PIK3R2 5296
Two-hybrid Homo sapiens
202 CD44 960
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
203 RPA1 6117
Affinity Capture-MS Homo sapiens
204 SLC1A1 6505
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
205 KLB 152831
Affinity Capture-Western Homo sapiens
206 JAK2 3717
Affinity Capture-Western Homo sapiens
207 C14orf37  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
208 GREM2 64388
Affinity Capture-MS Homo sapiens
209 HTR1A  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Co-localization Homo sapiens
View the network image/svg+xml
 Pathways in which FGFR1 is involved
PathwayEvidenceSource
Axon guidance IEA Reactome
Axon guidance TAS Reactome
Constitutive Signaling by Aberrant PI3K in Cancer TAS Reactome
Developmental Biology IEA Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downstream signaling of activated FGFR1 TAS Reactome
Epithelial-Mesenchymal Transition (EMT) during gastrulation IEA Reactome
FGFR1 ligand binding and activation TAS Reactome
FGFR1 mutant receptor activation TAS Reactome
FGFR1b ligand binding and activation TAS Reactome
FGFR1c and Klotho ligand binding and activation TAS Reactome
FGFR1c ligand binding and activation TAS Reactome
Formation of paraxial mesoderm IEA Reactome
FRS-mediated FGFR1 signaling TAS Reactome
Gastrulation IEA Reactome
IGF1R signaling cascade TAS Reactome
Insulin receptor signalling cascade TAS Reactome
Intracellular signaling by second messengers TAS Reactome
IRS-mediated signalling TAS Reactome
IRS-related events triggered by IGF1R TAS Reactome
L1CAM interactions TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
NCAM signaling for neurite out-growth IEA Reactome
Negative regulation of FGFR1 signaling TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Nervous system development IEA Reactome
Nervous system development TAS Reactome
Phospholipase C-mediated cascade: FGFR1 TAS Reactome
PI-3K cascade:FGFR1 TAS Reactome
PI3K Cascade TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
RAF/MAP kinase cascade TAS Reactome
SHC-mediated cascade:FGFR1 TAS Reactome
Signal Transduction TAS Reactome
Signal transduction by L1 TAS Reactome
Signaling by activated point mutants of FGFR1 TAS Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR in disease TAS Reactome
Signaling by FGFR1 TAS Reactome
Signaling by FGFR1 amplification mutants TAS Reactome
Signaling by FGFR1 in disease TAS Reactome
Signaling by Insulin receptor TAS Reactome
Signaling by plasma membrane FGFR1 fusions TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) TAS Reactome





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